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Sister Jean Ward, phototherapy, and jaundice: a unique human and photochemical interaction

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References

  1. Lucey JF . Light on jaundice. N Engl J Med 1969; 280: 1075–1076.

    CAS  Article  PubMed  Google Scholar 

  2. Dobbs RH, Cremer RJ . Phototherapy. Arch Dis Child 1975; 50: 833–836.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  3. Cremer RJ, Perryman PW, Richards DH . Influence of light on the hyperbilirubinemia of infants. Lancet 1958; 1: 1094–1097.

    CAS  Article  PubMed  Google Scholar 

  4. Slusher TM, Vreman HJ, Olusanya BO, Wong RJ, Brearley AM, Vaucher YE et al. Safety and efficacy of filtered sunlight in treatment of jaundice in African neonates. Pediatrics 2014; 133: e1568–e1574.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Franklin AW . Influence of light on the hyperbilirubinemia of infants. Lancet 1958; 1: 1227.

    Article  Google Scholar 

  6. Ferreira HC, Cardim WH, Mellone O . Fototerapia: novo recurso terapeutico na hiperbilirubinemia do recém-nascido. J Pediatr 1960; 25: 347–391.

    CAS  Google Scholar 

  7. Lucey JF, Ferreiro M, Hewitt J . Prevention of hyperbilirubinemia of prematurity by phototherapy. Pediatrics 1968; 41: 1047–1054.

    CAS  PubMed  Google Scholar 

  8. Broughton PMG, Rossiter EJR, Warren CBM, Goulis G, Lord PS . Effect of blue light on hyperbilirubinemia. Arch Dis Child 1965; 40: 666–671.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  9. Weiss EM, Zimmerman SS . A tale of two hospitals: the evolution of phototherapy treatment for neonatal jaundice. Pediatrics 2013; 131: 1032–1034.

    Article  PubMed  Google Scholar 

  10. Kopelman AE, Odell GB . Effects of phototherapy on neonatal hyperbilirubinemia. J Pediatr 1970; 77: 344–345.

    CAS  Article  PubMed  Google Scholar 

  11. Enge G, Klein SW . Hazards of phototherapy. N Engl J Med 1970; 283: 544–545.

    Google Scholar 

  12. Ostrow JD, Branham RV . Photo decomposition of bilirubin and biliverdin in vitro. Gastroenterology 1970; 58: 15.

    CAS  PubMed  Google Scholar 

  13. Lightner DA, McDonagh AF . Molecular mechanisms of phototherapy for neonatal jaundice. Acc Chem Res 1984; 17: 417–424.

    CAS  Article  Google Scholar 

  14. Onishi S, Isobe K, Itoh S, Kawade N, Sugiyama S . Demonstration of a geometric isomer of bilirubin 9-alpha in the serum of a hyperbilirubinemia newborn infant in the mechanism of jaundice phototherapy. Biochem J 1980; 190: 533–536.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  15. McDonagh AF . Phototherapy: a new twist to bilirubin. J Pediatr 1981; 99: 909–911.

    CAS  Article  PubMed  Google Scholar 

  16. McDonagh AF, Palma LA, Lightner DA . Phototherapy for neonatal jaundice: stereospecific and regioselective photoisomerization of bilirubin bound to human serum albumin and NMR characterization of intramolecularly cyclized photoproducts. J Am Chem Soc 1982; 104: 6867–6869.

    CAS  Article  Google Scholar 

  17. McDonagh AF . Mechanism of action of phototherapy. In: Levine RL, Maisels MJ (eds). Hyperbilirubinemia in the Newborn, Report of the 85th Ross Conference on Pediatric Research. Ross Laboratories: Columbus, OH, USA, 1983, pp 47–55.

    Google Scholar 

  18. Maisels MJ, McDonagh AF . Phototherapy for neonatal jaundice. N Engl J Med 2008; 358: 920–928.

    CAS  Article  PubMed  Google Scholar 

  19. McDonagh AF, Lightner DA . ‘Like a Shrivelled Blood Orange’—bilirubin, jaundice and phototherapy. Pediatrics 1985; 75: 443–455.

    CAS  PubMed  Google Scholar 

  20. Maisels MJ, Kring EA . Length of stay, jaundice and hospital readmission. Pediatrics 1998; 101: 995–998.

    CAS  Article  PubMed  Google Scholar 

  21. Eggert L, Wiedmeier SE, Wilson J, Christensen R . The effect of instituting a prehospital-discharge newborn bilirubin screening program in an 18-hospital health system. Pediatrics 2006; 117: e855–e862.

    Article  PubMed  Google Scholar 

  22. Bhutani VK, Johnson LH, Schwoebel A, Gennaro S . A systems approach for neonatal hyperbilirubinemia in term and near-term newborns. J Obstet Gynecol Neonatal Nurs 2006; 35: 444–455.

    Article  PubMed  Google Scholar 

  23. Maisels MJ . Phototherapy—traditional and nontraditional. J Perinatol 2001; 21: S93–S97.

    Article  PubMed  Google Scholar 

  24. O'Shea TM, Dillard RG, Klinepeter KL, Goldstein DJ . Serum bilirubin levels, intracranial hemorrhage, and the risk of developmental problems in very low birth weight infants. Pediatrics 1992; 90: 888–892.

    CAS  PubMed  Google Scholar 

  25. Morris BH, Oh W, Tyson JE, Stevenson D, Phelps DL, O’Shea TM et al. Aggressive vs conservative phototherapy for infants with extremely low birth weight. N Engl J Med 2008; 359: 1885–1896.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  26. Lightner DA . Understanding and translating bilirubin structure. Chapter 9, in Lightner DA, Bilirubin: Jekyll and Hyde Pigment of Life; Pursuit of Its Structure Through Two World Wars to the New Millenium. Vienna: Springer-Verlag, 2013, pp 525–603.

    Google Scholar 

  27. Csoma Z, Toth-Molnar E, Balogh K, Polyanka H, Orvo SH, Ocsai H et al. Neonatal blue light phototherapy and melanocytic nevi: a twin study. Pediatrics 2011; 128: e856–e864.

    Article  PubMed  Google Scholar 

  28. Cnattingius S, Zack MM, Ekbom A, Gunnarskog J, Kreuger A, Linet M et al. Prenatal and neonatal risk factors for childhood lymphatic leukemia. J Natl Cancer Inst 1995; 87: 908–914.

    CAS  Article  PubMed  Google Scholar 

  29. Dahlquist G, Kallen B . Indications that phototherapy is a risk factor for insulin-dependent diabetes. Diabetes Care 2003; 26: 247–248.

    Article  PubMed  Google Scholar 

  30. Roman E, Ansell P, Bull D . Leukaemia and non-Hodgkin’s lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease? Br J Cancer 1997; 76: 406–415.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  31. Robertson L, Harrild K . Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study. BMC Public Health 2010; 10: 281.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Galla A, Kitsiou-Tzeli S, Gourgiotis D, Hadjigerogiou E, Yousef-Ayash H, Kanarios J et al. Sister chromatid exchanges in peripheral lymphocytes in newborns treated with phototherapy and vitamin E. Acta Paediatr 1992; 81: 820–823.

    CAS  Article  PubMed  Google Scholar 

  33. Tatli MM, Minnet C, Kocyigit A, Karadag A . Phototherapy increases DNA damage in lymphocytes of hyperbilirubinemic neonates. Mutat Res 2008; 654: 93–95.

    CAS  Article  PubMed  Google Scholar 

  34. Aycicek A, Kocyigit A, Erel O, Senturk H . Phototherapy causes DNA damage in peripheral mononuclear leukocytes in term infants. J Pediatr (Rio J) 2008; 84: 141–146.

    Article  Google Scholar 

  35. Procianoy RS, Silveira RC, Fonseca LT, Heidemann LA, Neto EC . The influence of phototherapy on serum cytokine concentrations in newborn infants. Am J Perinatol 2010; 27: 375–379.

    Article  PubMed  Google Scholar 

  36. Kurt A, Aygun AD, Kurt AN, Godekmerdan A, Akarsu S, Yilmaz E . Use of phototherapy for neonatal hyperbilirubinemia affects cytokine production and lymphocyte subsets. Neonatology 2009; 95: 262–266.

    CAS  Article  PubMed  Google Scholar 

  37. Sirota L, Staussberg R, Gurary N, Aloni D, Bessler H . Phototherapy for neonatal hyperbilirubinemia affects cytokine production by peripheral blood mononuclear cells. Eur J Pediatr 1999; 158: 910–913.

    CAS  Article  PubMed  Google Scholar 

  38. Pezzati M, Biagiotti R, Vangi V, Lombardi E, Wiechmann L, Rubaltelli F . Changes in mesenteric blood flow response to feeding: conventional versus fiberoptic phototherapy. Pediatr 2000; 105: 350–353.

    CAS  Article  Google Scholar 

  39. Amato M, Donati F . Cerebral blood flow of velocity and term infants treated with phototherapy. Brain Dev 1991; 31: 417–419.

    Article  Google Scholar 

  40. Benders MJNL, van Bel F, van de Bor M . The effect of phototherapy on cerebral blood flow velocity in preterm infants. Acta Paediatr 1998; 87: 786–791.

    CAS  Article  PubMed  Google Scholar 

  41. Walther FJ, Wu PYK, Siassi B . Cardiac output changes in newborns with hyperbilirubinemia treated with phototherapy. Pediatrics 1985; 76: 918–921.

    CAS  PubMed  Google Scholar 

  42. Benders MJ, van Bel F, van de Bor M . The effect of phototherapy on renal blood flow velocity in preterm infants. Biol Neonate 1998; 73: 228–234.

    CAS  Article  PubMed  Google Scholar 

  43. Gathwala G, Sharma S . Phototherapy induces oxidative stress in premature neonates. Indian J Gastroenterol 2002; 21: 153–154.

    PubMed  Google Scholar 

  44. Gathwala G, Sharma S . Oxidative stress, phototherapy and the neonate. Indian J Pediatr 2000; 67: 805–808.

    CAS  Article  PubMed  Google Scholar 

  45. Aycicek A, Erel O . Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy. J Pediatr (Rio J) 2007; 83: 319–322.

    Google Scholar 

  46. Strauss KA, Robinson DL, Vreman HJ, Puffenberger EG, Hart G, Morton DH . Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. Eur J Pediatr 2006; 165: 306–319.

    Article  PubMed  Google Scholar 

  47. Suresh G, Lucey J . Lack of deafness in Crigler-Najjar syndrome type 1: A patient survey. Pediatrics 2000; 100: E9.

    Article  Google Scholar 

  48. Lipsitz PJ, Gartner LM, Bryla DA . Neonatal and infant mortality in relation to phototherapy. Pediatrics 1985; 75: 422–426.

    CAS  PubMed  Google Scholar 

  49. Poland R . Phototherapy for neonatal hyperbilirubinemia. Pediatrics 1986; 78: 179–180.

    CAS  PubMed  Google Scholar 

  50. Arnold C, Pedroza C, Tyson JE . Phototherapy in ELBW newborns: does it work? is it safe? The evidence from randomized clinical trials. Semin Perinatol 2014; 38: 452–464.

    Article  PubMed  Google Scholar 

  51. Scheidt PC, Bryla DA, Nelson KB, Hirtz DG, Hoffman HJ . Phototherapy for neonatal hyperbilirubinemia: Six year follow-up of the NICHD clinical trial. Pediatrics 1990; 85: 455–463.

    CAS  PubMed  Google Scholar 

  52. Scheidt PC, Graubard BI, Nelson KB, Hirtz DG, Hoffman HJ, Gartner LM et al. Intelligence at six years in relation to neonatal bilirubin level: follow-up of the National Institute of Child Health and Human Development Clinical Trial of Phototherapy. Pediatrics 1991; 87: 797–805.

    CAS  PubMed  Google Scholar 

  53. Tyson JE, Pedroza C, Langer J, Green C, Morris B, Stevenson D et al. Does aggressive phototherapy increase mortality while decreasing profound impairment among the smallest and sickest newborns? J Perinatol 2012; 32: 677–684.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  54. Vreman HJ, Knauer Y, Wong RJ, Chan M-L, Stevenson DK . Dermal carbon monoxide excretion in neonatal rats during light exposure. Pediatr Res 2009; 66: 66–69.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  55. Vreman HJ, Wong RJ, Stevenson DK . Phototherapy: current methods and future directions. Semin Perinatol 2004; 28: 326–333.

    Article  PubMed  Google Scholar 

  56. Maisels MJ, Watchko JF, Bhutani VK, Stevenson DK . An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation. J Perinatol 2012; 32: 660–664.

    CAS  Article  PubMed  Google Scholar 

  57. Arnold C, Tyson JE, Cuadrado ME et al. Cycled phototherapy: A safer effective treatment for small premature infants. E-PAS 2015; 1582.605. Abstract.

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Acknowledgements

I am grateful to Drs Jon Tyson, Tom Newman, Thor Hansen and Henk Vreman for their input and critical review of this manuscript and to Dr. Jerold Lucey for reviewing the manuscript and for many discussions over some 40 years about phototherapy and the jaundiced newborn.

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Correspondence to M J Maisels.

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Based on the Thomas E. Cone Jr, MD, Lecture on Perinatal History, given at the Section on Perinatal Pediatrics, American Academy of Pediatrics National Conference and Exhibition, Orlando, FL, 26 October 2013.

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Maisels, M. Sister Jean Ward, phototherapy, and jaundice: a unique human and photochemical interaction. J Perinatol 35, 671–675 (2015). https://doi.org/10.1038/jp.2015.56

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