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Lucey JF . Light on jaundice. N Engl J Med 1969; 280: 1075–1076.
Dobbs RH, Cremer RJ . Phototherapy. Arch Dis Child 1975; 50: 833–836.
Cremer RJ, Perryman PW, Richards DH . Influence of light on the hyperbilirubinemia of infants. Lancet 1958; 1: 1094–1097.
Slusher TM, Vreman HJ, Olusanya BO, Wong RJ, Brearley AM, Vaucher YE et al. Safety and efficacy of filtered sunlight in treatment of jaundice in African neonates. Pediatrics 2014; 133: e1568–e1574.
Franklin AW . Influence of light on the hyperbilirubinemia of infants. Lancet 1958; 1: 1227.
Ferreira HC, Cardim WH, Mellone O . Fototerapia: novo recurso terapeutico na hiperbilirubinemia do recém-nascido. J Pediatr 1960; 25: 347–391.
Lucey JF, Ferreiro M, Hewitt J . Prevention of hyperbilirubinemia of prematurity by phototherapy. Pediatrics 1968; 41: 1047–1054.
Broughton PMG, Rossiter EJR, Warren CBM, Goulis G, Lord PS . Effect of blue light on hyperbilirubinemia. Arch Dis Child 1965; 40: 666–671.
Weiss EM, Zimmerman SS . A tale of two hospitals: the evolution of phototherapy treatment for neonatal jaundice. Pediatrics 2013; 131: 1032–1034.
Kopelman AE, Odell GB . Effects of phototherapy on neonatal hyperbilirubinemia. J Pediatr 1970; 77: 344–345.
Enge G, Klein SW . Hazards of phototherapy. N Engl J Med 1970; 283: 544–545.
Ostrow JD, Branham RV . Photo decomposition of bilirubin and biliverdin in vitro. Gastroenterology 1970; 58: 15.
Lightner DA, McDonagh AF . Molecular mechanisms of phototherapy for neonatal jaundice. Acc Chem Res 1984; 17: 417–424.
Onishi S, Isobe K, Itoh S, Kawade N, Sugiyama S . Demonstration of a geometric isomer of bilirubin 9-alpha in the serum of a hyperbilirubinemia newborn infant in the mechanism of jaundice phototherapy. Biochem J 1980; 190: 533–536.
McDonagh AF . Phototherapy: a new twist to bilirubin. J Pediatr 1981; 99: 909–911.
McDonagh AF, Palma LA, Lightner DA . Phototherapy for neonatal jaundice: stereospecific and regioselective photoisomerization of bilirubin bound to human serum albumin and NMR characterization of intramolecularly cyclized photoproducts. J Am Chem Soc 1982; 104: 6867–6869.
McDonagh AF . Mechanism of action of phototherapy. In: Levine RL, Maisels MJ (eds). Hyperbilirubinemia in the Newborn, Report of the 85th Ross Conference on Pediatric Research. Ross Laboratories: Columbus, OH, USA, 1983, pp 47–55.
Maisels MJ, McDonagh AF . Phototherapy for neonatal jaundice. N Engl J Med 2008; 358: 920–928.
McDonagh AF, Lightner DA . ‘Like a Shrivelled Blood Orange’—bilirubin, jaundice and phototherapy. Pediatrics 1985; 75: 443–455.
Maisels MJ, Kring EA . Length of stay, jaundice and hospital readmission. Pediatrics 1998; 101: 995–998.
Eggert L, Wiedmeier SE, Wilson J, Christensen R . The effect of instituting a prehospital-discharge newborn bilirubin screening program in an 18-hospital health system. Pediatrics 2006; 117: e855–e862.
Bhutani VK, Johnson LH, Schwoebel A, Gennaro S . A systems approach for neonatal hyperbilirubinemia in term and near-term newborns. J Obstet Gynecol Neonatal Nurs 2006; 35: 444–455.
Maisels MJ . Phototherapy—traditional and nontraditional. J Perinatol 2001; 21: S93–S97.
O'Shea TM, Dillard RG, Klinepeter KL, Goldstein DJ . Serum bilirubin levels, intracranial hemorrhage, and the risk of developmental problems in very low birth weight infants. Pediatrics 1992; 90: 888–892.
Morris BH, Oh W, Tyson JE, Stevenson D, Phelps DL, O’Shea TM et al. Aggressive vs conservative phototherapy for infants with extremely low birth weight. N Engl J Med 2008; 359: 1885–1896.
Lightner DA . Understanding and translating bilirubin structure. Chapter 9, in Lightner DA, Bilirubin: Jekyll and Hyde Pigment of Life; Pursuit of Its Structure Through Two World Wars to the New Millenium. Vienna: Springer-Verlag, 2013, pp 525–603.
Csoma Z, Toth-Molnar E, Balogh K, Polyanka H, Orvo SH, Ocsai H et al. Neonatal blue light phototherapy and melanocytic nevi: a twin study. Pediatrics 2011; 128: e856–e864.
Cnattingius S, Zack MM, Ekbom A, Gunnarskog J, Kreuger A, Linet M et al. Prenatal and neonatal risk factors for childhood lymphatic leukemia. J Natl Cancer Inst 1995; 87: 908–914.
Dahlquist G, Kallen B . Indications that phototherapy is a risk factor for insulin-dependent diabetes. Diabetes Care 2003; 26: 247–248.
Roman E, Ansell P, Bull D . Leukaemia and non-Hodgkin’s lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease? Br J Cancer 1997; 76: 406–415.
Robertson L, Harrild K . Maternal and neonatal risk factors for childhood type 1 diabetes: a matched case-control study. BMC Public Health 2010; 10: 281.
Galla A, Kitsiou-Tzeli S, Gourgiotis D, Hadjigerogiou E, Yousef-Ayash H, Kanarios J et al. Sister chromatid exchanges in peripheral lymphocytes in newborns treated with phototherapy and vitamin E. Acta Paediatr 1992; 81: 820–823.
Tatli MM, Minnet C, Kocyigit A, Karadag A . Phototherapy increases DNA damage in lymphocytes of hyperbilirubinemic neonates. Mutat Res 2008; 654: 93–95.
Aycicek A, Kocyigit A, Erel O, Senturk H . Phototherapy causes DNA damage in peripheral mononuclear leukocytes in term infants. J Pediatr (Rio J) 2008; 84: 141–146.
Procianoy RS, Silveira RC, Fonseca LT, Heidemann LA, Neto EC . The influence of phototherapy on serum cytokine concentrations in newborn infants. Am J Perinatol 2010; 27: 375–379.
Kurt A, Aygun AD, Kurt AN, Godekmerdan A, Akarsu S, Yilmaz E . Use of phototherapy for neonatal hyperbilirubinemia affects cytokine production and lymphocyte subsets. Neonatology 2009; 95: 262–266.
Sirota L, Staussberg R, Gurary N, Aloni D, Bessler H . Phototherapy for neonatal hyperbilirubinemia affects cytokine production by peripheral blood mononuclear cells. Eur J Pediatr 1999; 158: 910–913.
Pezzati M, Biagiotti R, Vangi V, Lombardi E, Wiechmann L, Rubaltelli F . Changes in mesenteric blood flow response to feeding: conventional versus fiberoptic phototherapy. Pediatr 2000; 105: 350–353.
Amato M, Donati F . Cerebral blood flow of velocity and term infants treated with phototherapy. Brain Dev 1991; 31: 417–419.
Benders MJNL, van Bel F, van de Bor M . The effect of phototherapy on cerebral blood flow velocity in preterm infants. Acta Paediatr 1998; 87: 786–791.
Walther FJ, Wu PYK, Siassi B . Cardiac output changes in newborns with hyperbilirubinemia treated with phototherapy. Pediatrics 1985; 76: 918–921.
Benders MJ, van Bel F, van de Bor M . The effect of phototherapy on renal blood flow velocity in preterm infants. Biol Neonate 1998; 73: 228–234.
Gathwala G, Sharma S . Phototherapy induces oxidative stress in premature neonates. Indian J Gastroenterol 2002; 21: 153–154.
Gathwala G, Sharma S . Oxidative stress, phototherapy and the neonate. Indian J Pediatr 2000; 67: 805–808.
Aycicek A, Erel O . Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy. J Pediatr (Rio J) 2007; 83: 319–322.
Strauss KA, Robinson DL, Vreman HJ, Puffenberger EG, Hart G, Morton DH . Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease. Eur J Pediatr 2006; 165: 306–319.
Suresh G, Lucey J . Lack of deafness in Crigler-Najjar syndrome type 1: A patient survey. Pediatrics 2000; 100: E9.
Lipsitz PJ, Gartner LM, Bryla DA . Neonatal and infant mortality in relation to phototherapy. Pediatrics 1985; 75: 422–426.
Poland R . Phototherapy for neonatal hyperbilirubinemia. Pediatrics 1986; 78: 179–180.
Arnold C, Pedroza C, Tyson JE . Phototherapy in ELBW newborns: does it work? is it safe? The evidence from randomized clinical trials. Semin Perinatol 2014; 38: 452–464.
Scheidt PC, Bryla DA, Nelson KB, Hirtz DG, Hoffman HJ . Phototherapy for neonatal hyperbilirubinemia: Six year follow-up of the NICHD clinical trial. Pediatrics 1990; 85: 455–463.
Scheidt PC, Graubard BI, Nelson KB, Hirtz DG, Hoffman HJ, Gartner LM et al. Intelligence at six years in relation to neonatal bilirubin level: follow-up of the National Institute of Child Health and Human Development Clinical Trial of Phototherapy. Pediatrics 1991; 87: 797–805.
Tyson JE, Pedroza C, Langer J, Green C, Morris B, Stevenson D et al. Does aggressive phototherapy increase mortality while decreasing profound impairment among the smallest and sickest newborns? J Perinatol 2012; 32: 677–684.
Vreman HJ, Knauer Y, Wong RJ, Chan M-L, Stevenson DK . Dermal carbon monoxide excretion in neonatal rats during light exposure. Pediatr Res 2009; 66: 66–69.
Vreman HJ, Wong RJ, Stevenson DK . Phototherapy: current methods and future directions. Semin Perinatol 2004; 28: 326–333.
Maisels MJ, Watchko JF, Bhutani VK, Stevenson DK . An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation. J Perinatol 2012; 32: 660–664.
Arnold C, Tyson JE, Cuadrado ME et al. Cycled phototherapy: A safer effective treatment for small premature infants. E-PAS 2015; 1582.605. Abstract.
I am grateful to Drs Jon Tyson, Tom Newman, Thor Hansen and Henk Vreman for their input and critical review of this manuscript and to Dr. Jerold Lucey for reviewing the manuscript and for many discussions over some 40 years about phototherapy and the jaundiced newborn.
The author declares no conflict of interest.
Based on the Thomas E. Cone Jr, MD, Lecture on Perinatal History, given at the Section on Perinatal Pediatrics, American Academy of Pediatrics National Conference and Exhibition, Orlando, FL, 26 October 2013.
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Maisels, M. Sister Jean Ward, phototherapy, and jaundice: a unique human and photochemical interaction. J Perinatol 35, 671–675 (2015). https://doi.org/10.1038/jp.2015.56
Pediatric Research (2017)