Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perinatal/Neonatal Case Presentation
  • Published:

Perinatal/Neonatal Case Presentation

Inhaled nitric oxide in preterm infants with prolonged preterm rupture of the membranes: a case series

Abstract

The available evidence does not support the routine use of inhaled nitric oxide (iNO) in the care of premature infants. We present a case series of 22 preterm infants born after prolonged preterm premature rupture of membranes and oligohydramnios with respiratory failure. Oxygenation index decreased significantly after commencement of iNO.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Barrington KJ, Finer N . Inhaled nitric oxide for respiratory failure in preterm infants. Cochrane Database Syst Rev 2010; (12): CD000509.

    Google Scholar 

  2. Askie LM, Ballard RA, Cutter GR, Dani C, Elbourne D, Field D et al. Inhaled nitric oxide in preterm infants: an individual patient data meta-analysis of randomized controlled trials. Pediatrics 2011; 128: 729–739.

    Article  Google Scholar 

  3. Cole FS, Alleyne C, Barks JD, Boyle RJ, Carrol JL, Dokken D et al. NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants. Pediatrics 2011; 127: 363–369.

    Article  Google Scholar 

  4. Kilbride HW, Thibeault DW . Neonatal complications of preterm premature rupture of membranes. pathophysiology and management. Clin Perinatol 2001; 28: 761–785.

    Article  CAS  Google Scholar 

  5. Chock VY, Van Meurs KP, Hintz SR, Ehrenkranz RA, Lemons JA, Kendrick DE et alNICHD Neonatal Research Network. Inhaled nitric oxide for preterm premature rupture of membranes, oligohydramnios, and pulmonary hypoplasia. Am J Perinatol 2009; 26: 317–322.

    Article  Google Scholar 

  6. Geary C, Whitsett J . Inhaled nitric oxide for oligohydramnios induced pulmonary hypoplasia: a report of two cases and review of the literature. J Perinatol 2002; 22: 82–85.

    Article  Google Scholar 

  7. Aikio O, Metsola J, Vuolteenaho R, Perhomaa M, Hallman M . Transient defect in nitric oxide generation after rupture of fetal membranes and responsiveness to inhaled nitric oxide in very preterm infants with hypoxic respiratory failure. J Pediatr 2012; 161: 397–403.

    Article  CAS  Google Scholar 

  8. Kabra NS, Kluckow MR, Powell J . Nitric oxide in preterm infant with pulmonary hypoplasia. Indian J Pediatr 2004; 71: 427–429.

    Article  Google Scholar 

  9. Peliowski A, Finer NN, Etches PC, Tierney AJ, Ryan CA . Inhaled nitric oxide for premature infants after prolonged rupture of membranes. J Pediatr 1995; 126: 450–453.

    Article  CAS  Google Scholar 

  10. Williams O, Hutchings G, Debieve F, Debauche C . Contemporary neonatal outcome following rupture of membranes prior to 25 weeks with prolonged oligohydramnios. Early Hum Dev 2009; 85: 273–277.

    Article  CAS  Google Scholar 

  11. Welzing L, Bagci S, Abramian A, Bartmann P, Berg C, Mueller A . CPAP combined with inhaled nitric oxide for treatment of lung hypoplasia and persistent foetal circulation due to prolonged PPROM. Early Hum Dev 2011; 87: 17–20.

    Article  CAS  Google Scholar 

  12. Uga N, Ishii T, Kawase Y, Arai H, Tada H . Nitric oxide inhalation therapy in very low-birthweight infants with hypoplastic lung due to oligohydramnios. Pediatr Int 2004; 46: 10–14.

    Article  CAS  Google Scholar 

  13. The International Neonatal Network. The CRIB (clinical risk index for babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. Lancet 1993; 342: 193–198.

    Article  Google Scholar 

  14. Parry G, Tucker J, Tarnow-Mordi W . UK Neonatal Staffing Study Collaborative Group. CRIB II: an update of the clinical risk index for babies score. Lancet 2003; 361: 1789–1791.

    Article  Google Scholar 

  15. Van Meurs KP, Wright L, Ehrenkranz RA, Lemons JA, Ball MB, Poole WK et al. Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med 2005; 353: 13–22.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the EU FP7/2007–2013 under grant agreement no. 260777 (The HIP trial).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J Miletin.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Semberova, J., O'Donnell, S., Franta, J. et al. Inhaled nitric oxide in preterm infants with prolonged preterm rupture of the membranes: a case series. J Perinatol 35, 304–306 (2015). https://doi.org/10.1038/jp.2015.2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2015.2

This article is cited by

Search

Quick links