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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Toxic epidermal necrolysis in a neonate receiving fluconazole

Journal of Perinatology volume 34, pages 792–794 (2014)Cite this article

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Abstract

Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous condition, which may occur as an adverse reaction to a number of medications. The anitifungal agent, fluconazole, has been associated with TEN in limited reports, mainly in adults with HIV infection. We describe the case of a neonate with liver disease who developed TEN, presumably induced by fluconazole.

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References

  1. Roujeau JC, Stern R . Medical progress: severe cutaneous reactions to drugs. N Engl J Med 1994; 331: 1272–1285.

    Article  CAS  Google Scholar 

  2. Ofoma UR, Chapnick EK . Fluconazole induced toxic-epidermal necrolysis: a case report. Cases J 2009; 2: 9071.

    Article  Google Scholar 

  3. George J, Sharma A, Dixit R, Chabra N, Sharma S . Toxic epidermal necrolysis caused by fluconazole in a patient with human immunodefiency virus infection. J Pharmacol Pharmacother 2012; 3: 276–278.

    Article  CAS  Google Scholar 

  4. Paquet O, Pierard GE, Quatresooz P . Novel treatments for drug-induced toxic epidermal necrolysis (Lyell’s Syndrome). Int Arch Allergy Immunol 2005; 136: 205–216.

    Article  CAS  Google Scholar 

  5. Azon-Masoliver A, Vilaplana J . Fluconazole-induced toxic epidermal necrolysis in a patient with human immunodeficiency syndrome. Dermatology 1993; 187: 268–269.

    Article  CAS  Google Scholar 

  6. Gussenhoven MJ, Haak A, Peereboom-Wynia JD, Van’t Wout JW . Stevens-Johnson syndrome after fluconazole. Lancet 1991; 338: 120.

    Article  CAS  Google Scholar 

  7. Craythorne E, Creamer D . Stevens–Johnson syndrome due to prophylactic fluconazole in two patients with liver failure. Clin Exp Dermatol. 2009; 34 (7): e389–e390.

    Article  CAS  Google Scholar 

  8. Pasmatzi E, Monastirli A, Georgiou S, Sqouros G, Tsambaos D . Short-term and low-dose oral fluconazole treatment can cause Steven-Johnson-Syndrome in HIV-negative patients. J Drug Dermatol 2011; 10: 1360.

    Google Scholar 

  9. Levi N, Bastuji-Garin S, Mockenaupt M, Roujeau JC, Flahault A, Kelly JP et al. Medications as risk factors of Stevens-Johnson syndrome and toxic epidermal necrolysis in children: a pooled analysis. Pediatrics 2009; 123 (2): e297–e304.

    Article  Google Scholar 

  10. Egunsola O, Adefurin A, Fakis A, Jacqz-Aigran E, Choonara I, Sammons H et al. Safety of fluconazole in paediatrics: a systematic review. Eur J Clin Pharmacol 2013; 69: 1211–1212.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Infectious Diseases, Children’s Hospital and Research Center Oakland, Oakland, CA, USA

    S Islam, M Singer & J A Kulhanjian

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  1. S Islam
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  2. M Singer
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  3. J A Kulhanjian
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Correspondence to S Islam.

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Islam, S., Singer, M. & Kulhanjian, J. Toxic epidermal necrolysis in a neonate receiving fluconazole. J Perinatol 34, 792–794 (2014). https://doi.org/10.1038/jp.2014.92

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  • DOI: https://doi.org/10.1038/jp.2014.92

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