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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Treatment of congenital pulmonary lymphangiectasia using ethiodized oil lymphangiography

Abstract

Historically, congenital pulmonary lymphangiectasia (CPL) has had poor treatment outcomes despite aggressive therapy. There are recent reports of ethiodized oil (Lipiodol) lymphangiography successfully treating lymphatic leakage in adults. In this report, we describe two infants with CPL complicated by chylothoraces successfully treated by instillation of ethiodized oil into the lymphatic system. Congenital atresia of the thoracic duct was demonstrated on the lymphangiogram in both patients before treatment. Both patients have shown good short-term outcomes without supplemental oxygen or fat restricted diets at 9 months of age. Ethiodized oil lymphangiography represents a new treatment modality for some patients with CPL.

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References

  1. Esther CR Jr, Barker PM . Pulmonary lymphangiectasia: diagnosis and clinical course. Pediatr Pulmonol 2004; 38 (4): 308–313.

    Article  Google Scholar 

  2. Bouchard S, Di Lorenzo M, Youssef S, Simard P, Lapierre JG . Pulmonary lymphangiectasia revisited. J Pediatr Surg 2000; 35 (5): 796–800.

    Article  CAS  Google Scholar 

  3. Bellini C, Boccardo F, Campisi C, Toma P, Taddei G, Villa G et al. Congenital pulmonary lymphangiectasia. Orphanet J Rare Dis 2006; 1: 43.

    Article  Google Scholar 

  4. Alejandre-Lafont E, Krompiec C, Rau WS, Krombach GA . Effectiveness of therapeutic lymphography on lymphatic leakage. Acta Radiol 2011; 52 (3): 305–311.

    Article  Google Scholar 

  5. Matsumoto T, Yamagami T, Kato T, Hirota T, Yoshimatsu R, Masunami T et al. The effectiveness of lymphangiography as a treatment method for various chyle leakages. Br J Radiol 2009; 82 (976) 286–290.

    Article  CAS  Google Scholar 

  6. Nadolski GJ, Itkin M . Feasibility of ultrasound-guided intranodal lymphangiogram for thoracic duct embolization. J Vasc Interv Radiol 2012; 23 (5): 613–616.

    Article  Google Scholar 

  7. Clemens R, Kreindel T, Lillis A, Alomari A . Characterization of central conducting lymphatic anomalies. Pediatr Radiol 2013; 43 (Suppl 2) S319.

    Google Scholar 

  8. Rajebi MR, Chaudry G, Padua HM, Dillon B, Yilmaz S, Arnold RW et al. Intranodal lymphangiography: feasibility and preliminary experience in children. J Vasc Interv Radiol 2011; 22 (9): 1300–1305.

    Article  Google Scholar 

  9. Lo CM, Ngan H, Tso WK, Liu CL, Lam CM, Poon RT et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 2002; 35: 1164–1171.

    Article  CAS  Google Scholar 

  10. Yamagami T, Masunami T, Kato T, Tanaka O, Hirota T, Nomoto T et al. Spontaneous healing of chyle leakage after lymphangiography. Br J Radiol 2005; 78 (933): 854–857.

    Article  CAS  Google Scholar 

Download references

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Correspondence to H M French.

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Gray, M., Kovatis, K., Stuart, T. et al. Treatment of congenital pulmonary lymphangiectasia using ethiodized oil lymphangiography. J Perinatol 34, 720–722 (2014). https://doi.org/10.1038/jp.2014.71

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