Abstract
We describe a monozygotic twin discordant for VATER association with single dysplastic kidney and cloacal anomaly, who had no pulmonary hypoplasia. This twin probably had little or no urine output in utero, but still had normal lung development due to production of adequate amniotic fluid by the healthy twin preventing pulmonary hypoplasia. The discordance between monozygotic twins for VATER association indicates that factors other than inherited genetic ones may have a role in the causation of this association.
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References
Solomon BD . VACTERL/VATER association. Orphanet J Rare Dis 2011; 6: 56.
Klinger G, Merlob P, Aloni D, Maayan A, Sirota L . Normal pulmonary function in a monoamniotic twin discordant for bilateral renal agenesis: report and review. Am J Med Genet 1997; 73 (1): 76–79.
Potter EL . Bilateral renal agenesis. J Pediatr 1946; 29: 68–76.
Perlman M, Levin M . Fetal pulmonary hypoplasia, anuria, and oligohydramnios: clinicopathologic observations and review of the literature. Am J Obstet Gynecol 1974; 118 (8): 1119–1123.
Mauer SM, Dobrin RS, Vernier RL . Unilateral and bilateral renal agenesis in monoamniotic twins. J Pediatr 1974; 84 (2): 236–238.
Koffler H, Aase JM, Papile LA, Coen RW . Persistent cloaca with absent penis and anal atresia in one of identical twins. J Pediatr 1978; 93 (5): 821–823.
Cilento BG Jr., Benacerraf BR, Mandell J . Prenatal and postnatal findings in monochorionic, monoamniotic twins discordant for bilateral renal agenesis-dysgenesis (perinatal lethal renal disease). J Urol 1994; 151 (4): 1034–1035.
McNamara MF, McCurdy CM, Reed KL, Philipps AF, Seeds JW . The relation between pulmonary hypoplasia and amniotic fluid volume: lessons learned from discordant urinary tract anomalies in monoamniotic twins. Obstet Gynecol 1995; 85 (5 Pt 2): 867–869.
Perez-Brayfield MR, Kirsch AJ, Smith EA . Monoamniotic twin discordant for bilateral renal agenesis with normal pulmonary function. Urology 2004; 64 (3): 589.
Meyer SR, Smith KM, Ravish IR, Saltzman DA, Shukla AR . Complex cloacal anomaly in discordant monozygotic twins. Urology 2009; 73 (3): 532–534.
Hall JG . Twinning. Lancet 2003; 362 (9385): 735–743.
Singh SM, Murphy B, O'Reilly R . Epigenetic contributors to the discordance of monozygotic twins. Clin Genet 2002; 62 (2): 97–103.
Thompson SL, Konfortova G, Gregory RI, Reik W, Dean W, Feil R . Environmental effects on genomic imprinting in mammals. Toxicol Lett 2001; 120 (1–3): 143–150.
Esteller M . Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes. Eur J Cancer 2000; 36 (18): 2294–2300.
Mancini D, Singh S, Ainsworth P, Rodenhiser D . Constitutively methylated CpG dinucleotides as mutation hot spots in the retinoblastoma gene (RB1). Am J Hum Genet 1997; 61 (1): 80–87.
Bartels E, Schulz AC, Mora NW, Pineda-Alvarez DE, Wijers CH, Marcelis CM et al. VATER/VACTERL association: identification of seven new twin pairs, a systematic review of the literature, and a classical twin analysis. Clin Dysmorphol 2012; 21 (4): 191–195.
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Quinlan, J., Arora, P., Rane, S. et al. Monochorionic-monoamniotic twins discordant for VATER association. J Perinatol 34, 645–646 (2014). https://doi.org/10.1038/jp.2014.61
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DOI: https://doi.org/10.1038/jp.2014.61