Abstract
Macrophage activation syndrome (MAS) is a complication of rheumatic disorders characterized by cytopenia, multiple organ dysfunction and coagulopathy associated with an inappropriate activation of macrophage. In neonatal lupus erythematosus, MAS is rare but fatal, requiring early diagnosis and treatment for optimal outcome. We report a case of MAS in a neonate born to a mother with autoimmune disease, improved by treatment with steroid, intravenous immunoglobulin and cyclosporine.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Deane S, Selmi C, Teuber SS, Gershwin ME . Macrophage activation syndrome in autoimmune disease. Int Arch Allergy Immunol 2010; 153: 109–120.
Lin CI, Yu HH, Lee JH, Wang LC, Lin YT, Yang YH et al. Clinical analysis of macrophage activation syndrome in pediatric patients with autoimmune diseases. Clin Rheumatol 2012; 31: 1223–1230.
Parodi A, Davi S, Pringe AB, Pistorio A, Ruperto N, Magni-Manzoni S et al. Macrophage activation syndrome in juvenile systemic lupus erythematosus: a multinational multicenter study of thirty-eight patients. Arthritis Rheum 2009; 60: 3388–3399.
Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007; 48: 124–131.
Deane S, Selmi C, Teuber SS, Gershwin ME . Macrophage activation syndrome in autoimmune disease. Int Arch Allergy Immunol 2010; 153 (2): 109–120.
Brucato A, Cimaz R, Caporali R, Ramoni V, Buyon J . Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies. Clin Rev Allergy Immunol 2011; 40 (1): 27–41.
Suzuki Y, Takahashi N, Yada Y, Koike Y, Matano M, Nishimura H et al. Hemophagocytic lymphohistiocytosis in a newborn infant born to a mother with Sjogren syndrome antibodies. J Perinatol 2013; 33: 569–571.
Buyon JP, Clancy RM . Neonatal lupus syndromes. Curr Opin Rheumatol 2003; 15: 535–541.
Liu J, Yang YH, Lin YT, Chiang BL . Clinical characteristics of neonatal lupus erythematosus. J Microbiol Immunol Infect 2001; 34: 265–268.
Roberts I, Murray NA . Neonatal thrombocytopenia: causes and management. Arch Dis Child Fetal Neonatal Ed 2003; 88: F359–F364.
Freeman HR, Ramanan AV . Review of haemophagocytic lymphohistiocytosis. Arch Dis Child 2011; 96: 688–693.
Shander A, Cappellini MD, Goodnough LT . Iron overload and toxicity: the hidden risk of multiple blood transfusions. Vox Sang 2009; 97: 185–197.
Shander A, Sazama K . Clinical consequences of iron overload from chronic red blood cell transfusions, its diagnosis, and its management by chelation therapy. Transfusion 2010; 50: 1144–1155.
Kumakura S, Ishikura H, Kondo M, Murakawa Y, Masuda J, Kobayashi S . Autoimmune-associated hemophagocytic syndrome. Mod Rheumatol 2004; 14: 205–215.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Park, J., Kim, S., Kim, H. et al. Macrophage activation syndrome in a newborn infant born to a mother with autoimmune disease. J Perinatol 35, 158–160 (2015). https://doi.org/10.1038/jp.2014.207
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/jp.2014.207
This article is cited by
-
A case of recurrence of adult-onset Still’s disease in the third trimester: a case report and literature review
BMC Pregnancy and Childbirth (2021)
-
Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis
Inflammopharmacology (2018)