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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Coexistence of meconium ileus with duodenal atresia and trisomy 21 in a newborn: a case report

Journal of Perinatology volume 34, pages 875–876 (2014)Cite this article

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Abstract

The coexistence of duodenal atresia (DA) may mask the antenatal ultrasound findings of meconium ileus (MI) and delay its postnatal diagnosis. We report a rare case of MI in a newborn infant diagnosed antenatally to have trisomy 21 and DA. The diagnosis of MI was only established intraoperatively after the patient showed persistent signs of intestinal obstruction following the surgical repair of the DA.

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References

  1. Park RW, Grand RJ . Gastrointestinal manifestation of cystic fibrosis: a review. Gastroenterology 1961; 81: 1143–1161.

    Google Scholar 

  2. Scotet V, Dugueperoux I, Audrezet MP, Audebert-Bellanger S, Muller M, Blayau M et al. Focus on cystic fibrosis and other disorders evidenced in fetuses with sonographic finding of echogenic bowel: 16-year report from Brittany, France. Am J Obstet Gynecol 2010; 203: 592.e1–6.

    Article  Google Scholar 

  3. Bahado-Singh R, Morotti R, Copel JA, Mahoney MJ . Hyperechoic fetal bowel: the perinatal consequences. Prenat Diagn 1994; 14: 981–987.

    Article  CAS  Google Scholar 

  4. Carlyle BE, Borowitz DS, Glick PL . A review of pathophysiology and management of fetuses and neonates with meconium ileus for the pediatric surgeon. J Pediatr Surg 2012; 47 (4): 772–781.

    Article  Google Scholar 

  5. O’Rahilly R, Muller F . Human Embryology and Teratology. Wiley-Liss: New York, 1996 p 229.

    Google Scholar 

  6. Louw JH, Barnard CN . Congenital intestinal atresia; observations on its origin. Lancet 1955; 269 (6899): 1065–1067.

    Article  CAS  Google Scholar 

  7. Fonkalsrud EW, de Lorimer AA, Hays DM . Congenital atresia and stenosis of the duodenum: a review compiled from the members of the surgical section. Am Acad Pediatr 1969; 43: 79–83.

    CAS  Google Scholar 

  8. Choudhry MS, Rahman N, Boyd P, Lakhoo K . Duodenal atresia: associated anomalies, prenatal diagnosis and outcome. Pediatr Surg Int 2009; 25 (8): 727–730.

    Article  CAS  Google Scholar 

  9. Rapoport S, Buchanan DJ . The composition of meconium; isolation of blood-group-specific polysaccharides; abnormal compositions of meconium in meconium ileus. Science 1950; 112 (2901): 150–153.

    Article  CAS  Google Scholar 

  10. Guy EL, Peckham DG, Brownlee KG, Conway SP, Lee TW . Cystic fibrosis co-existing with trisomy 21. J Cyst Fibros. 2010; 9 (5): 330–331.

    Article  CAS  Google Scholar 

  11. Milunsky A . Cystic fibrosis and Down's syndrome. Pediatrics 1968; 42: 501–504.

    CAS  PubMed  Google Scholar 

  12. Vetrella M, BartheImai W, Matsuda H . Down's syndrome and cystic fibrosis. Pediatrics 1969; 43: 905–906.

    CAS  PubMed  Google Scholar 

  13. Kruger C, Barmeier H, Sailer R, Harms D . Cystic fibrosis in Down's syndrome-diagnostic pitfalls and implications for the clinician. Arch Dis Child 1998; 78: 194.

    Article  CAS  Google Scholar 

  14. Munck A, Gerardin M, Alberti C, Ajzenman C, Lebourgeois M, Aigrain Y et al. Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort study. J Pediatr Surg 2006; 41: 1556–1560.

    Article  Google Scholar 

  15. Efrati O, Nir J, Fraser D, Cohen-Cymberknoh M, Shoseyov D, Vilozni D et al. Meconium ileus in patients with cystic fibrosis is not a risk factor for clinical deterioration and survival: the Israeli Multicenter Study. J Pediatr Gastroenterol Nutr 2010; 50: 173–178.

    Article  Google Scholar 

  16. Johnson JA, Bush A, Buchdahl R . Does presenting with meconium ileus affect the prognosis of children with cystic fibrosis? Pediatr Pulmonol 2010; 45: 951–958.

    Article  Google Scholar 

Download references

Acknowledgements

Dr Olusegun Akinloye wrote the first draft of the manuscript. This project was conducted with no specific financial support. No honorarium, grant or other form of payment was given to anyone to produce this manuscript.

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Authors and Affiliations

  1. Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS, Canada,

    O W Akinloye & W El-Naggar

  2. Department of Surgery, Dalhousie University, Halifax, NS, Canada

    W Truong & M Giacomantonio

  3. Department of Respirology, Dalhousie University, Halifax, NS, Canada,

    D Mateos

Authors
  1. O W Akinloye
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  2. W Truong
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  3. M Giacomantonio
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  4. D Mateos
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  5. W El-Naggar
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Corresponding author

Correspondence to W El-Naggar.

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Akinloye, O., Truong, W., Giacomantonio, M. et al. Coexistence of meconium ileus with duodenal atresia and trisomy 21 in a newborn: a case report. J Perinatol 34, 875–876 (2014). https://doi.org/10.1038/jp.2014.124

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  • DOI: https://doi.org/10.1038/jp.2014.124

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