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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Case Report: Congenital rubella syndrome: a rare but persistent concern in the United States

Journal of Perinatology volume 33, pages 899–902 (2013)Cite this article

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Abstract

In countries such as the United States where rubella virus infections are rare, congenital rubella syndrome (CRS) may not be recognized in a timely manner. However, the syndrome still appears in this country, often in infants of mothers emigrating from countries with absent or suboptimal national vaccination programs. We describe a case of CRS in a term baby born to a recent US immigrant who developed a primary varicella infection in late pregnancy and demonstrated IgG titers to rubella at delivery. At presentation, the neonate had both classical findings as well as less reported vascular and neurological abnormalities seen in infants with CRS.

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References

  1. Centers for Disease Control and Prevention. Elimination of rubella and congenital rubella syndrome - United States, 1969-2004. Morb Mortal Wkly Rep 2005; 54: 279–282.

    Google Scholar 

  2. Reef SE, Redd SB, Abernathy E, Zimmerman L, Icenogle JP . The epidemiological profile of rubella and congenital rubella syndrome in the United States, 1998-2004: the evidence for absence of endemic transmission. Clin Infect Dis 2006; 43: S126–S132.

    Article  Google Scholar 

  3. Centers for Disease Control and Prevention. Three cases of congenital rubella syndrome in the postelimination era - Maryland, Alabama, and Illinois, 2012. Morb Mortal Wkly Rep 2013; 62: 226–229.

    Google Scholar 

  4. Caidi H, Abernathy ES, Benjouad A, Smit S, Bwogi J, Nanyunja M et al. Phylogenetic analysis of rubella viruses found in Morocco, Uganda, Cote d’Ivoire, and South Africa from 2001 to 2007. J Clin Virol 2008; 42: 86–90.

    Article  CAS  Google Scholar 

  5. Gregg N . Congenital cataract following German measles in the mother. Trans Ophthalmol Soc Aust 1941; 3: 35–46.

    Google Scholar 

  6. Givens KT, Lee DA, Jones T, Ilstrup DM . Congenital rubella syndrome: ophthalmic manifestations and associated systemic disorders. Br J Ophthalmol 1993; 77: 358–363.

    Article  CAS  Google Scholar 

  7. Wolff SM . The ocular manifestations of congenital rubella. Trans Am Ophthalmol Soc 1972; 70: 577–614.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. American Academy of Pediatrics. Rubella In: Pickering LK, Baker CJ, Kimberlin DW, Long SS (eds). Red Book: 2012 Report of the Committee on Infectious Diseases 29th ed Elk Grove Village, IL: American Academy of Pediatrics, 2012 p 629–634.

    Google Scholar 

  9. Desmond MM, Wilson GS, Vorderman AL, Murphy MA, Thurber S, Fisher ES et al. The health and educational status of adolescents with congenital rubella syndrome. Dev Med Child Neurol 1985; 27: 721–729.

    Article  CAS  Google Scholar 

  10. Ishikawa A, Murayama T, Sakuma N, Takase A, Shishido T, Nagamatsu K et al. Computed cranial tomography in congenital rubella syndrome. Arch Neurol 1982; 39: 420–421.

    Article  CAS  Google Scholar 

  11. Bale J . Fetal infections and brain development. Clin Perinatol 2009; 36: 639–653.

    Article  Google Scholar 

  12. Lanari M, Capretti MG, Lazzarotto T . Neuroimaging examination of newborns in vertically acquired infections. J Matern Fetal Neonatal Med 2011; 24: 117–119.

    Article  Google Scholar 

  13. Beltinger C, Saule H . Sonography of subependymal cysts in congenital rubella syndrome. Eur J Pediatr 1988; 148: 206–207.

    Article  CAS  Google Scholar 

  14. Hua M, Odibo A, Macones G, Roehl K, Crane J, Cahill A . Single umbilical artery and its associated findings. Obstet Gynecol 2010; 115: 930–934.

    Article  Google Scholar 

  15. Naeve RL, Blanc W . Pathogenesis of congenital rubella. JAMA 1965; 194: 1277–1283.

    Article  Google Scholar 

  16. Moore CM . Single umbilical artery and congenital rubella. J Pediatr 1969; 75: 157–158.

    Article  CAS  Google Scholar 

  17. Webster W . Teratogen update: congenital rubella. Teratology 1998; 58: 13–23.

    Article  CAS  Google Scholar 

  18. Berger BE, Omer SB . Could the United States experience rubella outbreaks as a result of vaccine refusal and disease importation? Hum Vaccin 2010; 6: 1016–1020.

    Article  Google Scholar 

  19. Goodson JL, Masresha B, Dosseh A, Byabamazima C, Nshimirimana D, Cochi S et al. Rubella epidemiology in Africa in the prevaccine era, 2002–2009. J Infect Dis 2011; 204: S215–S225.

    Article  Google Scholar 

  20. Centers for Disease Control and Prevention. Progress toward control of rubella and prevention of congenital rubella syndrome - worldwide, 2009. Morb Mortal Wkly Rep 2010; 59: 1307–1310.

    Google Scholar 

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Author notes

  1. A Agrawal

    Present address: 8Current address: Desert Neonatology Associates, Banner Thunderbird Medical Center, 5555W. Thunderbird Road, Glendale, AZ 85306, USA.,

Authors and Affiliations

  1. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    J Fang & E Jalazo

  2. Eudowood Neonatal Pulmonary Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    A Agrawal & W C Golden

  3. Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    S Gowtham

  4. Division of Pediatric Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    R J Felling

  5. Division of Pediatric Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    H-JS Park

  6. Department of Pathology, Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    A Valsamakis

  7. Division of Pediatric Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA

    T A G M Huisman

Authors
  1. J Fang
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  9. W C Golden
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Corresponding author

Correspondence to W C Golden.

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The authors declare no conflict of interest.

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Supplementary Information accompanies the paper on the Journal of Perinatology website

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Fang, J., Agrawal, A., Gowtham, S. et al. Case Report: Congenital rubella syndrome: a rare but persistent concern in the United States. J Perinatol 33, 899–902 (2013). https://doi.org/10.1038/jp.2013.73

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