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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Bartter syndrome: presentation in an extremely premature neonate

Abstract

Reports of Bartter syndrome in premature neonates are rare. We describe the presentation and clinical course of a neonate born at 25.6 weeks estimated gestational age with polyuria, hyponatremia, hypokalemia and hypercalciuria ,who was diagnosed with neonatal Bartter syndrome. The evaluation, diagnosis and management of neonatal Bartter syndrome in this premature neonate are discussed.

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References

  1. Seyberth HA . An improved terminology and classification of Bartter-like syndromes. Nat Clin Pract Nephrol 2008; 4 (10): 560–567.

    Article  Google Scholar 

  2. Fremont OT, Chan JCM . Understanding Bartter syndrome and Gitelman syndrome. World J Pediatr 2012; 8 (1): 25–30.

    Article  Google Scholar 

  3. Frassetto LA Bartter Syndrome. Medscape Reference-Drugs, Diseases and Procedures. Available at http://emedicine.medscape.com/article/238670-overview . Updated 2012.

  4. Bhat YR, Vinayaka G, Sreelakshmi K . Antenatal Bartter Syndrome: a Review. Int J Pediatr 2012 2012; 857136 doi:10.1155/2012/857136.

  5. Hallak M, Kirshon B, Smith EO, Cotton DB . Amniotic fluid index. Gestational age-specific values for normal human pregnancy. J Reprod Med 1993 Nov; 38 (11): 853–856.

    CAS  PubMed  Google Scholar 

  6. Bartter PC, Pronove P, Gill JR, MacCardle RC . Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis: a new syndrome. Amer J Med 1962; 33: 811–828.

    Article  CAS  Google Scholar 

  7. Bhat YR, Vinayaka G, Vani R, Prashanth KA, Sreelakshmi K . Antenatal Bartter syndrome: a rare cause of unexplained severe polyhydramnios. Ann Trop Paediatr 2011; 31: 153–157.

    Article  CAS  Google Scholar 

  8. Massa G, Proesmans W, Devlieger H, Vandenberghe K, Van Assche A, Eggermont E . Electrolyte composition of the amniotic fluid in Bartter syndrome. Eur J Obstet Gynecol Reprod Biol 1987; 24: 335–340.

    Article  CAS  Google Scholar 

  9. Amirlak I, Dawson KP . Bartter syndrome: an overview. QJM 2000; 94 (4): 207–215.

    Article  Google Scholar 

  10. Puricelli E, Bettinelli A, Borsa N, Sironi F, Mattiello C, Tammaro F et al. Long-term follow-up of patients with Bartter syndrome type I and II. Neph Dial Transplant 2010; 25 (9): 2976–2981.

    Article  Google Scholar 

  11. Reinalter S, Devlieger H, Proesmans W . Neonatal Bartter syndrome: spontaneous resolution of all signs and symptoms. Pediat Nephrol 1998; 12 (3): 186–188.

    Article  CAS  Google Scholar 

  12. Brochard K, Boyer O, Blanchard A, Loirat C, Niaudet P, Macher MA et al. Phenotype-genotype correlation in antenatal and neonatal variants of Bartter syndrome. Nephrol Dial Transplant 2009; 24: 1455–1464.

    Article  CAS  Google Scholar 

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Acknowledgements

We thank Terry Wolfe, RN for her meticulous care and management of this premature neonate during the first days of her life.

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Correspondence to D A Calhoun.

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The authors declare no conflict of interest.

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Dr. Calhoun conceived and drafted the original manuscript. Drs. Calhoun, Ojeda and Flores have been responsible for the revisions and content included in the previous drafts leading up to the final version of the manuscript. Each physician was involved in the medical management of this neonate.

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Flores, F., Ojeda, F. & Calhoun, D. Bartter syndrome: presentation in an extremely premature neonate. J Perinatol 33, 661–662 (2013). https://doi.org/10.1038/jp.2013.13

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