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William A Silverman lecture

Abstract

This is the text of the William A Silverman lecture given by Dr David K Stevenson at the Pediatric Academic Societies Annual Meeting in Washington, DC, May 4–7, 2013.

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References

  1. Silverman WA, Andersen DH, Blanc WA, Crozier DN . A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens. Pediatrics 1956; 18: 614–625.

    PubMed  Google Scholar 

  2. Ahdab-Barmada M, Moossy J . The neuropathology of kernicterus in the premature neonate: diagnostic problems. J Neuropathol Exp Neurol 1984; 43: 45–56.

    Article  CAS  Google Scholar 

  3. Maisels MJ, Watchko JF . Treatment of jaundice in low birthweight infants. Arch Dis Child Fetal Neonatal Ed 2003; 88: F459–F463.

    Article  CAS  Google Scholar 

  4. Oh W, Tyson JE, Fanaroff AA, Vohr BR, Perritt R, Stoll BJ et al. Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants. Pediatrics 2003; 112: 773–779.

    Article  Google Scholar 

  5. Okumura A, Kidokoro H, Shoji H, Nakazawa T, Mimaki M, Fujii K et al. Kernicterus in preterm infants. Pediatrics 2009; 123: e1052–e1058.

    Article  Google Scholar 

  6. Penn AA, Enzmann DR, Hahn JS, Stevenson DK . Kernicterus in a full term infant. Pediatrics 1994; 93: 1003–1006.

    CAS  Google Scholar 

  7. AmericanAcademyofPediatrics. Management of hyperbilirubinemia in the newborn infant ≥35 weeks of gestation. Pediatrics 2004; 114: 297–316.

    Article  Google Scholar 

  8. Sgro M, Campbell D, Shah V . Incidence and causes of severe neonatal hyperbilirubinemia in Canada. CMAJ 2006; 175: 587–590.

    Article  Google Scholar 

  9. Hansen TW, Nietsch L, Norman E, Bjerre JV, Hascoet JM, Mreihil K et al. Reversibility of acute intermediate phase bilirubin encephalopathy. Acta Paediatr 2009; 98: 1689–1694.

    Article  Google Scholar 

  10. Vreman HJ, Wong RJ, Stevenson DK . Phototherapy: current methods and future directions. Semin Perinatol 2004; 28: 326–333.

    Article  Google Scholar 

  11. McDonagh AF, Lightner DA . Phototherapy and the photobiology of bilirubin. Semin Liver Dis 1988; 8: 272–283.

    Article  CAS  Google Scholar 

  12. Silverman WA . Ambitious overgeneralisation. Paediatr Perinat Epidemiol 2002; 16: 288–289.

    Article  Google Scholar 

  13. Morris BH, Oh W, Tyson JE, Stevenson DK, Phelps DL, O'Shea TM et al. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med 2008; 359: 1885–1896.

    Article  CAS  Google Scholar 

  14. Tenhunen R, Marver HS, Schmid R . The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 1968; 61: 748–755.

    Article  CAS  Google Scholar 

  15. Stevenson DK, Vreman HJ, Oh W, Fanaroff AA, Wright LL, Lemons JA et al. Bilirubin production in healthy term infants as measured by carbon monoxide in breath. Clin Chem 1994; 40: 1934–1939.

    CAS  PubMed  Google Scholar 

  16. Loboda A, Jazwa A, Grochot-Przeczek A, Rutkowski AJ, Cisowski J, Agarwal A et al. Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2008; 10: 1767–1812.

    Article  CAS  Google Scholar 

  17. Vreman HJ, Knauer Y, Wong RJ, Chan ML, Stevenson DK . Dermal carbon monoxide excretion in neonatal rats during light exposure. Pediatr Res 2009; 66: 66–69.

    Article  CAS  Google Scholar 

  18. Vreman HJ, Wong RJ, Sanesi CA, Dennery PA, Stevenson DK . Simultaneous production of carbon monoxide and thiobarbituric acid reactive substances in rat tissue preparations by an iron-ascorbate system. Can J Physiol Pharmacol 1998; 76: 1057–1065.

    Article  CAS  Google Scholar 

  19. Vreman HJ, Wong RJ, Stevenson DK . Carbon monoxide in breath, blood, and other tissues In: Penney DG, (ed) Carbon Monoxide Toxicity. CRC Press: Boca Raton, FL, USA, 2000 pp 19–60.

    Chapter  Google Scholar 

  20. Stevenson DK, Ostrander CE, Johnson JD . Effect of erythrocyte destruction on the pulmonary excretion rate of carbon monoxide in adult male Wistar rats. J Lab Clin Med 1979; 94: 649–654.

    CAS  PubMed  Google Scholar 

  21. Smith DW, Hopper AO, Shahin SM, Cohen RS, Ostrander CR, Ariagno RL et al. Neonatal bilirubin production estimated from "end-tidal" carbon monoxide concentration. J Pediatr Gastroenterol Nutr 1984; 3: 77–80.

    Article  CAS  Google Scholar 

  22. Vreman HJ, Cipkala DA, Stevenson DK . Characterization of porphyrin heme oxygenase inhibitors. Can J Physiol Pharmacol 1996; 74: 278–285.

    CAS  Google Scholar 

  23. Vreman HJ, Rodgers PA, Gale R, Stevenson DK . Carbon monoxide excretion as an index of bilirubin production in rhesus monkeys. J Med Primatol 1989; 18: 449–460.

    CAS  PubMed  Google Scholar 

  24. Vreman HJ, Rodgers PA, Stevenson DK . Zinc protoporphyrin administration for suppression of increased bilirubin production by iatrogenic hemolysis in rhesus neonates. J Pediatr 1990; 117: 292–297.

    Article  CAS  Google Scholar 

  25. Zhang W, Feng JQ, Harris SE, Contag PR, Stevenson DK, Contag CH . Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expression. Transgenic Res 2001; 10: 423–434.

    Article  CAS  Google Scholar 

  26. Zhang W, Contag PR, Hardy J, Zhao H, Vreman HJ, Hajdena-Dawson M et al. Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1. J Mol Med (Berl) 2002; 80: 655–664.

    Article  CAS  Google Scholar 

  27. Kaplan M, Renbaum P, Levy-Lahad E, Hammerman C, Lahad A, Beutler E . Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia. Proc Natl Acad Sci USA 1997; 94: 12128–12132.

    Article  CAS  Google Scholar 

  28. Bhutani VK, Johnson L, Sivieri EM . Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics 1999; 103: 6–14.

    Article  CAS  Google Scholar 

  29. Silverman WA . Informed consent in customary practice and in clinical trials In: Goldworth A, Silverman WA, Stevenson DK, Young EWD, Rivers R, (eds) Ethics and Perinatology. Oxford University Press: Oxford, UK, 1995 pp 245–262.

    Google Scholar 

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Acknowledgements

This work was supported by the National Institutes of Health Grants #HD058663-01A2 and #HL68703-07, the Mary L. Johnson Research Fund, the Christopher Hess Research Fund and the H.M. Lui Research Fund.

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Correspondence to D K Stevenson.

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Stevenson, D. William A Silverman lecture. J Perinatol 34, 1–5 (2014). https://doi.org/10.1038/jp.2013.104

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