Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Perinatal/Neonatal Case Presentation

Endotracheal DNase for atelectasis in ventilated neonates

Abstract

Management of atelectasis and lung collapse in ventilated neonates remains a common challenge in the neonatal intensive care unit. Recombinant human DNase (rhDNase) is an established treatment of atelectasis in cystic fibrosis and its use is also reported in the management of asthma, respiratory syncitial virus bronchiolitis and bronchiectasis to liquefy sputum and aid its clearance from the lungs. We report the use of rhDNase in a subgroup of ventilated neonates with severe end-stage respiratory failure and atelectasis. Three of the four patients showed clinical improvement. A previously undiagnosed lung anomaly was subsequently identified in the fourth patient. Future randomized studies could examine any potential benefits of this emerging therapy.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Hendriks T, de Hoog M, Lequin MH, Devos AS, Merkus PJFM . DNase and atelectasis in non-cystic fibrosis pediatric patients. Critical Care 2005; 9: R351–R356.

    Article  Google Scholar 

  2. Shak S, Capon DJ, Hellmiss R, Masters SA, Baker CL . Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum. Proc Natl Acad Sci USA 1990; 87: 9188–9192.

    CAS  Article  Google Scholar 

  3. Boogaard R, de Jongste JC, Merkus PJFM . Pharmacotherapy of impaired mucociliary clearance in non-CF pediatric lung disease. A review of the literature. Pediatr Pulmonol 2007; 42: 989–1001.

    Article  Google Scholar 

  4. El Hassan NO, Huysman MWA . Rescue use of DNase in critical lung atelectasis and mucus retention in premature neonates. Pediatrics 2001; 108: 468–471.

    CAS  Article  Google Scholar 

  5. Erdeve O, Uras N, Atasay B, Arsan S . Efficacy and safety of nebulized recombinant human DNase as rescue treatment of persistent atelectasis in newborns: case series. Croat Med J 2007; 48: 234–239.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Dragerwerk AG . LG Babylog 8000 Plus: intensive care ventilator for neonates instructions for use, software 5.n: nebulizing medicaments. 2008.

  7. Boogaard R, Hulsmann AR, van Veen L, Vaessen-Verberne AAPH, Yap YN, Sprij AJ, Brinkhorst G et al. Recombinant human deoxyribonuclease in infants with respiratory syncytial virus bronchiolitis. Chest 2007; 131: 788–795.

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R MacKinnon.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

MacKinnon, R., Wheeler, K. & Sokol, J. Endotracheal DNase for atelectasis in ventilated neonates. J Perinatol 31, 799–801 (2011). https://doi.org/10.1038/jp.2011.38

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2011.38

Keywords

  • DNase
  • atelectasis
  • neonatal ventilation

Search

Quick links