Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perinatal/Neonatal Case Presentation
  • Published:

Perinatal/Neonatal Case Presentation

Management of granulomatous common variable immunodeficiency diagnosed in pregnancy: a case report

Abstract

Common variable immunodeficiency (CVID) is a rare condition that affects women of childbearing age with important implications in pregnancy. It is characterised by low immunoglobulins (Igs), poor antibody response and a susceptibility to recurrent infections. The cornerstone of management of CVID is Ig replacement. As the transfer of IgG across the placenta in the third trimester of pregnancy is necessary for protection of the infant in the first months of life, failure to recognise this condition and treat it appropriately can have adverse consequences for the neonate, as well as the mother. Here we describe the complex perinatal medical management of a 34-year-old woman who was diagnosed with CVID in the 26th week of pregnancy.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Cunningham-Rundles C . How I treat common variable immune deficiency. Blood 2010; 116: 7–15.

    Article  CAS  Google Scholar 

  2. Ardeniz O, Cunningham-Rundles C . Granulomatous disease in common variable immunodeficiency. Clin Immunol 2009; 133: 198–207.

    Article  CAS  Google Scholar 

  3. Blore J, Haeney MR . Primary antibody deficiency and diagnostic delay. BMJ 1989; 298: 516–517.

    Article  CAS  Google Scholar 

  4. Palmeira P, Costa-Carvalho BT, Arslanian C, Pontes GN, Nagao AP, Carneiro-Sampaio MMS . Transfer of antibodies across the placenta and in breast milk from mothers on intravenous immunoglobulin. Pediatr Allergy Immunol 2009; 20: 528–535.

    Article  Google Scholar 

  5. Gardulf A, Andersson E, Lindqvist M, Hansen S, Gustafson R . Rapid subcutaneous IgG replacement therapy at home for pregnant immunodeficient women. J Clin Immunol 2001; 21: 150–154.

    Article  CAS  Google Scholar 

  6. Dalakas MC . The use of intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: evidence-based indications and safety profile. Pharmacol Therapeut 2004; 102: 177–193.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A L Manson.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Manson, A., Zaheri, S., Kelleher, P. et al. Management of granulomatous common variable immunodeficiency diagnosed in pregnancy: a case report. J Perinatol 32, 387–389 (2012). https://doi.org/10.1038/jp.2011.127

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2011.127

Keywords

This article is cited by

Search

Quick links