Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perinatal/Neonatal Case Presentation
  • Published:

Perinatal/Neonatal Case Presentation

Diaphragm dysfunction with congenital cytomegalovirus infection

Journal of Perinatology volume 30, pages 691–694 (2010)Cite this article

Subjects

Abstract

Congenital cytomegalovirus infection can cause a wide variety of symptoms. We report three infants with congenital cytomegalovirus infection presenting with respiratory insufficiency associated with persistent diaphragmatic dysfunction. Congenital cytomegalovirus infection should be considered in the differential diagnosis of neonatal diaphragmatic dysfunction.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Malm G, Engman ML . Congenital cytomegalovirus infections. Semin Fetal Neonatal Med 2007; 12 (3): 154–159.

    Article  Google Scholar 

  2. Wayne ER, Burrington JD, Myers DN, Cotton E, Block W . Letter: bilateral eventration of the diaphragm in a neonate with congenital cytomegalic inclusion disease. J Pediatr 1973; 83 (1): 164–165.

    Article  CAS  Google Scholar 

  3. Becroft DM . Prenatal cytomegalovirus infection and muscular deficiency (eventration) of the diaphragm. J Pediatr 1979; 94 (1): 74–75.

    Article  CAS  Google Scholar 

  4. Ross SA, Boppana SB . Congenital cytomegalovirus infection: outcome and diagnosis. Semin Pediatr Infect Dis 2005; 16 (1): 44–49.

    Article  Google Scholar 

  5. Tsutsui Y, Kosugi I, Kawasaki H . Neuropathogenesis in cytomegalovirus infection: indication of the mechanisms using mouse models. Rev Med Virol 2005; 15 (5): 327–345.

    Article  CAS  Google Scholar 

  6. Bale Jr JF, Bray PF, Bell WE . Neuroradiographic abnormalities in congenital cytomegalovirus infection. Pediatr Neurol 1985; 1 (1): 42–47.

    Article  Google Scholar 

  7. van der Knaap MS, Vermeulen G, Barkhof F, Hart AA, Loeber JG, Weel JF . Pattern of white matter abnormalities at MR imaging: use of polymerase chain reaction testing of Guthrie cards to link pattern with congenital cytomegalovirus infection. Radiology 2004; 230 (2): 529–536.

    Article  Google Scholar 

  8. Ackerman KG, Greer JJ . Development of the diaphragm and genetic mouse models of diaphragmatic defects. Am J Med Genet C Semin Med Genet 2007; 145C (2): 109–116.

    Article  CAS  Google Scholar 

  9. Vassilakopoulos T, Petrof BJ . Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 2004; 169 (3): 336–341.

    Article  Google Scholar 

  10. Jubran A . Critical illness and mechanical ventilation: effects on the diaphragm. Respir Care 2006; 51 (9): 1054–1061; discussion 1062–1054.

    PubMed  Google Scholar 

  11. Vassilakopoulos T . Ventilator-induced diaphragm dysfunction: the clinical relevance of animal models. Intensive Care Med 2008; 34 (1): 7–16.

    Article  CAS  Google Scholar 

  12. Tonks A, Wyldes M, Somerset DA, Dent K, Abhyankar A, Bagchi I et al. Congenital malformations of the diaphragm: findings of the West Midlands Congenital Anomaly Register 1995 to 2000. Prenat Diagn 2004; 24 (8): 596–604.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Rainbow Babies and Children's Hospital, Cleveland, OH, USA

    K Izumi, S E McCandless & D I Craven

  2. Center for Human Genetics, University Hospitals Case Medical Center, Cleveland, OH, USA

    K Izumi & S E McCandless

  3. Department of Genetics, Case Western Reserve University, Cleveland, OH, USA

    K Izumi, L Rice & S E McCandless

  4. Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan

    I Hokuto, A Uezono & K Ikeda

  5. Department of Pediatrics, Kasumigaura Medical Center, Tsuchiura, Japan

    S Yamaguchi

  6. Division of Pediatric Pulmonology, Rainbow Babies and Children's Hospital, Cleveland, OH, USA

    D I Craven

Authors
  1. K Izumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I Hokuto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Yamaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Uezono
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K Ikeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L Rice
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S E McCandless
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. D I Craven
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D I Craven.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Izumi, K., Hokuto, I., Yamaguchi, S. et al. Diaphragm dysfunction with congenital cytomegalovirus infection. J Perinatol 30, 691–694 (2010). https://doi.org/10.1038/jp.2010.65

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2010.65

Keywords

Search

Advanced search

Quick links