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The use of Omegaven in treating parenteral nutrition-associated liver disease


Parenteral nutrition (PN), containing fat emulsions derived from soybean, has been implicated in the progression of PN-associated liver disease and cholestasis, particularly in infants with short bowel syndrome. Clinical use of Omegaven, a parenteral fish-oil emulsion, has been shown in recent studies to be a promising therapy to reverse liver disease and cholestasis. This review summarizes the rationale, relevant clinical investigations and future direction of Omegaven therapy for PN-dependent infants.

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  31., Identifier: NCT00512629.

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This work was supported in part by the Carl and Patricia Dierkes Endowment Fund for Nutrition Support and Home Care.

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Correspondence to J Kerner Jr.

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Park, K., Nespor, C. & Kerner, J. The use of Omegaven in treating parenteral nutrition-associated liver disease. J Perinatol 31 (Suppl 1), S57–S60 (2011).

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