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The use of Omegaven in treating parenteral nutrition-associated liver disease

Journal of Perinatology volume 31, pages S57–S60 (2011)Cite this article

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Abstract

Parenteral nutrition (PN), containing fat emulsions derived from soybean, has been implicated in the progression of PN-associated liver disease and cholestasis, particularly in infants with short bowel syndrome. Clinical use of Omegaven, a parenteral fish-oil emulsion, has been shown in recent studies to be a promising therapy to reverse liver disease and cholestasis. This review summarizes the rationale, relevant clinical investigations and future direction of Omegaven therapy for PN-dependent infants.

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Acknowledgements

This work was supported in part by the Carl and Patricia Dierkes Endowment Fund for Nutrition Support and Home Care.

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Authors and Affiliations

  1. Department of Pediatric Gastroenterology, Stanford University Medical Center, Lucile Packard Children's Hospital, Palo Alto, CA, USA

    K T Park & J Kerner Jr

  2. Department of Pharmacy, Stanford University Medical Center, Lucile Packard Children's Hospital, Palo Alto, CA, USA

    C Nespor

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  1. K T Park
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Correspondence to J Kerner Jr.

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Park, K., Nespor, C. & Kerner, J. The use of Omegaven in treating parenteral nutrition-associated liver disease. J Perinatol 31 (Suppl 1), S57–S60 (2011). https://doi.org/10.1038/jp.2010.182

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