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Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysis

Journal of Human Hypertension volume 31, pages 855–856 (2017)Cite this article

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We read an article written by Wolley et al.1 with interest. We found that treatment of primary aldosteronism by adrenalectomy or aldosterone antagonists was associated with a reduction in the severity of obstructive sleep apnoea (OSA). Although resistant hypertension (RH) is highly prevalent in patients with OSA and hyperaldosteronism, the authors did not recruit participants with RH. We completed a meta-analysis to assess the effect of aldosterone antagonists on OSA in patients with RH.

We searched PubMed, Embase, Web of Science and Cochrane Database until June 2017. Studies were included if they met the following criteria:1 studies primarily aimed to evaluate the effect of aldosterone antagonists on OSA;2 included participants with RH. Case reports, reviews, conference abstracts and experiments were excluded. Review Manager 5.3 (Cochrane Collaboration, Oxford, UK) was used for all statistical analyses. Random-effects models were applied to synthesize data across studies. Median (interquartile range) was used to conservatively estimate mean±s.d. via the formula provided in Cochrane Handbook for Systematic Reviews of Interventions. P<0.05 was considered significant.

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References

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Authors and Affiliations

  1. Department of Cardiology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China

    W-D Zhang, J-W Zhang, K-F Wu, Y-P Wang, L-H Zhou, H-T Wang & S-M Chen

  2. Medical College of Shantou University, Shantou, Guangdong, China

    W-D Zhang & X Chen

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  1. W-D Zhang
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Correspondence to S-M Chen.

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Zhang, WD., Zhang, JW., Wu, KF. et al. Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysis. J Hum Hypertens 31, 855–856 (2017). https://doi.org/10.1038/jhh.2017.70

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