Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Association of G-protein β3 subunit C825T polymorphism with essential hypertension: evidence from 63 729 subjects

Journal of Human Hypertension volume 31, pages 511–514 (2017)Cite this article

Subjects

Abstract

Many studies have reported that G-protein β3 subunit (GNB3) C825T polymorphism is associated with essential hypertension (EH), although this remains subject to debate. Thus, meta-analysis was carried out to clarify this relationship. A total of 75 articles, reporting 81 case–control studies evaluating 28 369 patients and 34 933 control individuals, were assessed. Overall, a significant association was observed in the dominant model (odds ratio (OR)=1.11, 95% CI 1.04–1.19), recessive model (OR=1.09, 95% CI 1.01–1.17), TT vs CC (OR=1.16, 95% CI 1.05–1.28), CT vs CC (OR=1.09, 95% CI 1.02–1.17), and additive model (OR=1.07, 95% CI 1.02–1.13) after pooling all eligible studies. Subgroup analysis by ethnicity and gender demonstrated significantly increased EH only in Caucasians using the dominant (OR=1.22, 95% CI 1.07–1.39; TT vs CC, OR=1.29, 95% CI 1.07–1.54; CT vs CC, OR=1.19, 95% CI 1.05–1.35) and additive (OR=1.16, 95% CI 1.05–1.28) models. In summary, the present meta-analysis indicated the GNB3 C825T polymorphism is related to increased EH exclusively in Caucasians.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. He J, Whelton PK . Epidemiology and prevention of hypertension. Med Clin North Am 1997; 81 (5): 1077–1097.

    Article  CAS  Google Scholar 

  2. Whelton PK . Epidemiology of hypertension. Lancet 1994; 344 (8915): 101–106.

    Article  CAS  Google Scholar 

  3. Williams SM, Addy JH, Phillips JA III, Dai M, Kpodonu J, Afful J et al. Combinations of variations in multiple genes are associated with hypertension. Hypertension 2000; 36 (1): 2–6.

    Article  CAS  Google Scholar 

  4. Wang W, Lee ET, Fabsitz RR, Devereux R, Best L, Welty TK et al. A longitudinal study of hypertension risk factors and their relation to cardiovascular disease: the Strong Heart Study. Hypertension 2006; 47 (3): 403–409.

    Article  CAS  Google Scholar 

  5. Neves SR, Ram PT, Lyengar R . G protein pathway. Science 2002; 296 (5573): 1636–1639.

    Article  CAS  Google Scholar 

  6. Siffert W . G protein polymorphisms in hypertension, atherosclerosis, and diabetes. Annu Rev Med 2005; 56: 17–28.

    Article  CAS  Google Scholar 

  7. Elefsinioti AL, Bagos PG, Spyropoulos IC, Hamodrakas SJ . A database for G proteins and their interaction with GPCRs. BMC Bioinformatics 2004; 5: 208.

    Article  Google Scholar 

  8. Bagos PG, Elefsinioti AL, Nikolopoulos GK, Hamodrakas SJ . The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17,760 controls. J Hypertens 2007; 25 (3): 487–500.

    Article  CAS  Google Scholar 

  9. Andersen G, Overgaard J, Albrechtsen A, Glümer C, Borch-Johnsen K, Jørgensen T et al. Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes. Diabetologia 2006; 49 (1): 75–82.

    Article  CAS  Google Scholar 

  10. Zheng H, Xu H, Cui B, Xie N, Wang Z, Luo M . Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects. Biol Res 2013; 46 (3): 265–273.

    Article  Google Scholar 

  11. Higgins JP, Thompson SG, Deeks JJ, Altman DG . Measuring inconsistency in meta-analysis. BMJ 2003; 327 (7414): 557–560.

    Article  Google Scholar 

  12. Mantel N, Haenszel W . Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22 (4): 19–748.

    Google Scholar 

  13. DerSimonian R, Kacker R . Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials 2007; 28 (2): 105–114.

    Article  Google Scholar 

  14. DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials 1986; 7 (3): 177–188.

    Article  CAS  Google Scholar 

  15. Begg CB, Mazumdar M . Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50 (4): 1088–1101.

    Article  CAS  Google Scholar 

  16. Egger M, Smith DG, Schneider M, Minder C . Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315 (7109):629–634.

    Article  CAS  Google Scholar 

  17. Rosskopf D, Schürks M, Rimmbach C, Schäfers R . Genetics of arterial hypertension and hypotension. Naunyn Schmiedebergs Arch Pharmacol 2007; 374 (5–6): 429–469.

    Article  CAS  Google Scholar 

  18. Melien O . Heterotrimeric G proteins and disease. Methods Mol Biol 2007; 361: 119–144.

    CAS  PubMed  Google Scholar 

  19. Siffert W, Rosskopf D, Moritz A, Wieland T, Kaldenberg-Stasch S, Kettler N et al. Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension. J Clin Invest 1995; 96 (2): 759–766.

    Article  CAS  Google Scholar 

  20. Daimon M, Sato H, Sasaki S, Toriyama S, Emi M, Muramatsu M et al. Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM. Biochem Biophys Res Commun 2008; 374 (3): 576–580.

    Article  CAS  Google Scholar 

  21. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K . A comprehensive review of genetic association studies. Genet Med 2002; 4 (2): 45–61.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The present study was funded by the Shanxi Province Natural Science Foundation (nos 2012011040-3 and 2013011049-4), the Scientific Research Foundation of High Education Institutions of Shanxi Province (no. 200811034), the Program for Innovative Research Team in Changzhi Medical College (cx201406), and the Research Project of Shanxi Provincial Health and Family Planning Commission (201602026 and 201602028), the High School 131 leading talent project of Shanxi Province, National undergraduate innovation and entrepreneurship training programmes (201610117001).

Author information

Authors and Affiliations

  1. Department of Cardiology, Heping Hospital and Institute of Cardiovascular Disease, Changzhi Medical College, Changzhi, China

    S-L Rong

  2. Department of Preventive Medicine, Changzhi Medical College, Changzhi, China

    J-Z Zheng

  3. Department of Pediatrics, Heping Hospital and Institute of Cardiovascular Disease, Changzhi Medical College, Changzhi, China

    X-L Wang

  4. Department of Physiology, Changzhi Medical College, Changzhi, China

    C-Y Zhang

  5. Department of Biological Chemistry, Changzhi Medical College, Changzhi, China

    J Su

  6. Department of Cardiology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

    B Li

Authors
  1. S-L Rong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J-Z Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. X-L Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C-Y Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to X-L Wang.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies this paper on the Journal of Human Hypertension website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rong, SL., Zheng, JZ., Wang, XL. et al. Association of G-protein β3 subunit C825T polymorphism with essential hypertension: evidence from 63 729 subjects. J Hum Hypertens 31, 511–514 (2017). https://doi.org/10.1038/jhh.2017.31

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jhh.2017.31

Search

Advanced search

Quick links