Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Left ventricular longitudinal rotation changes in primary hypertension patients with normal left ventricular ejection fraction detected by two-dimensional speckle tracking imaging

Journal of Human Hypertension volume 30, pages 30–34 (2016)Cite this article

Subjects

Abstract

In order to assess the left ventricular (LV) longitudinal rotation (LR) in primary hypertension (PH) patients with a normal LV ejection fraction. Conventional echocardiography was performed in 61 healthy subjects and 64 PH patients. The apical four-chamber views in these patients were acquired by GE-Vivid7 or E9, then the peak radial strain in the systolic period and the strain rate in systole, in early and late diastolic periods, were measured. Segmental LR and global LR were assessed by using two-dimensional speckle tracking imaging (2D-STI). The peak radial strain rate in the early diastolic period in PH patients was significantly lower than that in healthy subjects. The rotational degrees of the middle and base lateral, the apex and the middle septum walls in PH patients were significantly different from those of the healthy subjects. The healthy subjects had prominent counter-clockwise LR (0.29°±2.86°) and the PH patients had prominent clockwise LR (−2.13°±2.93°) in non-LV wall hypertrophy and (−2.43°±2.66°) in LV wall hypertrophy. The time delay between the LV lateral wall and the septum wall in PH patients correlated to the peak LR. We concluded that 2D-STI can assess the time delay between the LV lateral wall and the septum wall to the peak LR and clockwise LR in patients with PH, and prove that PH patients have a clockwise LR. By this, we conclude that in PH patients, the LV early systolic function have changed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. Lorell BH, Carab ello BA . Left ventricular hypertrophy: pathogenesis, detection, and prognosis. Circulation 2000; 102 (4): 470–479.

    Article  CAS  Google Scholar 

  2. Edvardsen T, Rosen BD, Pan L, Jerosch-Hero ld M, Lai S, Hundley WG et al. Regional diastolic dysfunction in individuals with left ventricular hypertrophy measured by tagged magnetic resonance imaging—the Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2006; 151 (1): 109–114.

    Article  Google Scholar 

  3. Takeuchi M, Borden WB, Nakai H, Nishikage T, Kokumai M, Nagakura T et al. Reduced and delayed untwisting of the left ventricle in patients with hypertension and left ventricular hypertrophy: a study using two-dimensional speckle tracking imaging. Eur Heart J 2007; 28 (22): 2756–2762.

    Article  Google Scholar 

  4. Mu Y, Qin C, Wang C, Huojiaabudula G . Two-dimensional ultrasound speckle tracking imaging in evaluation of early changes in left ventricular diastolic function in patients with essential hypertension. Echocardiography 2010; 27 (2): 146–154.

    Article  Google Scholar 

  5. Mizuguchi Y, Oishi Y, Miyoshi H, Iuchi A, Nagase N, Oki T . Concentric left ventricular hypertrophy brings deterioration of systolic longitudinal, circumferential, and radial myocardial deformation in hypertensive patients with preserved left ventricular pump function. J Cardiol 2010; 55 (1): 23–33.

    Article  Google Scholar 

  6. Mizuguchi Y, Oishi Y, Miyoshi H, Iuchi A, Nagase N, Ara N et al. Possible mechanisms of left ventricular torsion evaluated by cardioreparative effects of telmisartan in patients with hypertension. Eur J Echocardiogr 2010; 11 (8): 690–697.

    Article  Google Scholar 

  7. Galderisi M, Lomoriello VS, Santoro A, Esposito R, Olibet M, Raia R et al. Differences of myocardial systolic deformation and correlates of diastolic function in competitive rowers and young hypertensives: a speckle-tracking echocardiography study. J Am Soc Echocardiogr 2010; 23 (11): 1190–1198.

    Article  Google Scholar 

  8. van Dalen BM, Soliman OI, Vletter WB, ten Cate FJ, Geleijnse ML . Age-related changes in the biomechanics of left ventricular twist measured by speckle tracking echocardiography. Am J Physiol Heart Circ Physiol 2008; 295 (4): H1705–H1711.

    Article  CAS  Google Scholar 

  9. Notomi Y, Lysyansky P, Setser RM, Shiota T, Popović ZB, Martin-Miklovic MG et al. Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging. J Am Coll Cardiol 2005; 45 (12): 2034–2041.

    Article  Google Scholar 

  10. Takeuchi M, Nishikage T, Nakai H, Kokumai M, Otani S, Lang RM . The assessment of left ventricular twist in anterior wall myocardial infarction using two-dimensional speckle tracking imaging. J Am Soc Echocardiogr 2007; 20 (1): 36–44.

    Article  Google Scholar 

  11. Chetboul V, Serres F, Gouni V, Tissier R, Pouchelon JL . Noninvasive assessment of systolic left ventricular torsion by 2-dimensional speckle tracking imaging in the awake dog: repeatability, reproducibility, and comparison with tissue Doppler imaging variables. J Vet Intern Med 2008; 22 (2): 342–350.

    Article  CAS  Google Scholar 

  12. Helle-Valle T, Crosby J, Edvardsen T, Lyseggen E, Amundsen BH, Smith HJ et al. New noninvasive method for assessment of left ventricular rotation: speckle tracking echocardiography. Circulation 2005; 112 (20): 3149–3156.

    Article  Google Scholar 

  13. Saito M, Okayama H, Nishimura K, Ogimoto A, Ohtsuka T, Inoue K et al. Determinants of left ventricular untwisting behaviour in patients with dilated cardiomyopathy: analysis by two-dimensional speckle tracking. Heart 2009; 95 (4): 290–296.

    Article  CAS  Google Scholar 

  14. Bertini M, Sengupta PP, Nucifora G, Delgado V, Ng AC, Marsan NA et al. Role of left ventricular twist mechanics in the assessment of cardiac dyssynchrony in heart failure. JACC Cardiovasc Imaging 2009; 2 (12): 1425–1435.

    Article  Google Scholar 

  15. van Dalen BM, Soliman OI, Vletter WB, Kauer F, van der Zwaan HB, ten Cate FJ et al. Feasibility and reproducibility of left ventricular rotation parameters measured by speckle tracking echocardiography. Eur J Echocardiogr 2009; 10 (5): 669–676.

    Article  Google Scholar 

  16. van Dalen BM, Kauer F, Soliman OI, Vletter WB, Michels M, ten Cate FJ et al. Influence of the pattern of hypertrophy on left ventricular twist in hypertrophic cardiomyopathy. Heart 2009; 95 (8): 657–661.

    Article  CAS  Google Scholar 

  17. Popović ZB, Grimm RA, Ahmad A, Agler D, Favia M, Dan G et al. Longitudinal rotation: an unrecognised motion pattern in patients with dilated cardiomyopathy. Heart 2007; 94 (3): 1–6.

    Google Scholar 

  18. Huang J, Ni XD, Hu YP, Song ZW, Yang WY, Xu R . Left ventricular longitudinal rotation changes in patients with dilated cardiography detected by two-dimensional speckle tracking imaging. Chin J Cardio 2011; 39 (10): 920–924.

    Google Scholar 

  19. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G et al. Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension(ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25 (6): 1105–1187.

    Article  CAS  Google Scholar 

  20. Hammond IW, Devereux RB, Alderman MH, Lutas EM, Spitzer MC, Crowley JS et al. The prevalence and correlates of echocardiography left ventricular hypertrophy among employed patients with uncomplicated hypertension. J Am Coll Cardiol 1986; 7 (3): 639–650.

    Article  CAS  Google Scholar 

  21. Ganau A, Devereux RB, Roman MJ, de Simone G, Pickering TG, Saba PS et al. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol 1992; 19 (7): 1550–1558.

    Article  CAS  Google Scholar 

  22. Kouzu H, Yuda S, Muranaka A, Doi T, Yamamoto H, Shimoshige S et al. Left ventricular hypertrophy causes different changes in longitudinal, radial, and circumferential mechanics in patients with hypertension: a two-dimensional speckle tracking study. J Am Soc Echocardiogr 2011; 24 (2): 192–199.

    Article  Google Scholar 

  23. Cappelli F, Porciani MC, Bergesio F, Perfetto F, De Antoniis F, Cania A et al. Characteristics of left ventricular rotational mechanics in patients with systemic amyloidosis, systemic hypertension and normal left ventricular mass. Clin Physiol Funct Imaging 2011; 31 (2): 159–165.

    PubMed  Google Scholar 

  24. Greenbaum RA, Ho SY, Gibson DG, Becker AE, Anderson RH . Left ventricular fibre architecture in man. Br Heart 1981; 45 (3): 248–263.

    Article  CAS  Google Scholar 

  25. Henein MY, Gibson DG . Editorial normal long axis function. Heart 1999; 81 (2): 111–113.

    Article  CAS  Google Scholar 

  26. Weber KT, Brilla CG, Janicki JS . Myocardial fibrosis: functional significance and regulators. Cardiovascular Res 1993; 27 (3): 341–348.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We would like to thank the Department of Echocardiography, ChangZhou No. 2 People’s Hospital Affiliated to NanJing Medical University and the Department of Ultrasound, The First Affiliated Hospital of WenZhou Medical University.

Author information

Authors and Affiliations

  1. Department of Echocardiography, ChangZhou No. 2 People’s Hospital Affiliated to NanJing Medical University, ChangZhou, China

    J Huang, Z-N Yan, Y-F Rui, L Fan, D Shen & D-L Chen

  2. Department of Ultrasound, The First Affiliated Hospital of WenZhou Medical University, WenZhou, China

    X-D Ni & Y-P Hu

Authors
  1. J Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z-N Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. X-D Ni
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y-P Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Y-F Rui
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. D-L Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Z-N Yan.

Ethics declarations

Competing interests

The author declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang, J., Yan, ZN., Ni, XD. et al. Left ventricular longitudinal rotation changes in primary hypertension patients with normal left ventricular ejection fraction detected by two-dimensional speckle tracking imaging. J Hum Hypertens 30, 30–34 (2016). https://doi.org/10.1038/jhh.2015.25

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jhh.2015.25

This article is cited by

Search

Advanced search

Quick links