Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Impact of a short home-based yoga programme on blood pressure in patients with hypertension: a randomized controlled trial in primary care


The present study was designed to evaluate yoga's impact on blood pressure (BP) and quality of life (QOL) and on stress, depression and anxiety in patients with hypertension in a primary care setting. We conducted a multi-centre randomized controlled trial with follow-up after 12-week intervention completion. Adult primary care patients diagnosed with hypertension were randomly allocated to yoga or usual care. The intervention group performed a short home-based Kundalini yoga programme 15 min twice-daily during the 12-week intervention period. At baseline and follow-up, the participants underwent standardized BP measurements and completed questionnaires on QOL, stress, anxiety and depression. Data obtained from 191 patients (mean age 64.7 years, s.d. 8.4) allocated to yoga intervention (n=96) and control group (n=95), with a total proportion of 52% women, showed a significant reduction in systolic and diastolic BP for both groups (−3.8/−1.7 mm Hg for yoga and −4.5/−3.0 mm Hg for control groups, respectively). However, the BP reduction for the yoga group was not significantly different from control. There were small but significant improvements for the yoga group in some of the QOL and depression measures (P<0.05, Hospital Anxiety and Depression scale, HADS-D) compared with control. The findings of our study, which is the largest study from an OECD country (Organization for Economic Co-operation and Development) to date, do not support the suggestion from previous smaller studies that yoga lowers the BP. Further clinical trials are needed to confirm these findings. However, the yoga patients had other health benefits.


A recent multi-national study suggests that the prevalence of hypertension in adults is around 40%.1 Hypertension is important not only because of its high frequency but also because it is a major modifiable risk factor for heart disease, stroke and kidney disease, which are among the most common causes of death worldwide.2, 3 For primary care physicians, hypertension is the number one diagnosis for office visits and for our communities, the treatment of high blood pressure (BP) and its consequences constitutes a substantial economic burden.4, 5 The primary care physician faces a considerable challenge in trying to convince hypertensive patients to implement and maintain lifestyle changes, including dietary changes and increased physical activity.

Yoga is a mind-body practice in complementary and alternative medicine with origins in ancient Indian philosophy.6 Yoga is gaining popularity as a therapeutic measure in the western world, and a majority of yoga practitioners in America have reported that they utilize yoga to improve their health status.7 In several studies, yoga has been shown to reduce BP.8, 9, 10 However, many of these studies have been small and of questionable power to determine clinically relevant (that is, 4–5 mm Hg) changes in BP,9, 10 and the need for larger randomized trials has been highlighted.11 Furthermore, it is important to study the effects of yoga on BP in a primary health-care setting, where most patients with hypertension are evaluated and managed.

There are several theories about the pathogenesis of hypertension and about how BP is affected by yoga. According to a previous study, slow breathing increases baroreceptor sensitivity and reduces sympathetic activity and chemoreflex activation.12 Yoga exercise can increase heart rate variability, indicating an increase in parasympathetic activity.13 It has also been shown in a previous study that yoga can reduce levels of cortisol in saliva.14 The mechanisms by which cortisol raises BP remain unknown, but it is suggested that it might be through inhibition of the vasodilator nitric oxide system and through increased vasoconstrictor erythropoietin concentration.15

Our research group conducted a small pilot study in 2011, which evaluated yoga as a treatment for primary care patients with hypertension.16 The results suggested that a short home-based programme of yoga had a BP-lowering effect and a positive effect on self-rated quality of life (QOL).16 In view of this, we decided to conduct a new and larger randomized trial to further evaluate the effect of the home-based yoga programme on BP. We also chose to examine whether the slight improvement observed in QOL was related to stress, depression and/or anxiety. According to the advice from the founder of the yoga intervention, Göran Boll, we increased the intervention in the present study from 15 min daily to 15 min twice-daily.17 Other studies have shown positive effects of yoga on health-related QOL,18 stress,8 anxiety8, 19 and depression.20 However, systematic reviews have pointed out the need for larger randomized trials in these areas as well.18, 20

The present study was designed to evaluate yoga’s impact on BP and QOL and on stress, depression and anxiety in patients with hypertension presenting to primary care physicians.

Materials and methods

Trial design

We conducted a multi-centre parallel group randomized controlled trial with follow-up after 12-week intervention completion. An a priori sample size calculation determined that 200 patients were required (100 per group) to allow 80% power to detect as significant at the 5% level, a 5 mm Hg between-group difference in systolic BP, allowing for 15% dropouts (two-sided test). The primary outcome was change in BP. The key secondary outcome was self-rated QOL (World Health Organization Quality of Life Assessment, WHOQOL-BREF).21 Other secondary outcomes included stress (Perceived Stress Scale, PSS),22 depression and anxiety (Hospital Anxiety and Depression Scale, HADS).23 To ensure allocation concealment, randomization to groups was undertaken by a research assistant not involved in recruitment using a computer-generated random number schedule with block size of four. Randomization to study groups occurred after completion of baseline assessments and questionnaires. We used the CONSORT 2010 guidelines from the website

The study design and procedures were approved by the Regional Ethical Review Board in Lund, Sweden (2013/262). The study was registered at (NCT01984593).

Participants and recruitment

In September 2013, patients aged 30–80 years old with diagnosed hypertension were identified by electronic charts search at three health-care centres in southern Sweden. The health-care centres were chosen on the basis that they had general practitioners (GPs) willing to commit time for research on yoga and hypertension. Participants were invited to participate if their BP when most recently measured at the health-care centre was between 130 and 160 mm Hg (systolic) and 85 and 100 mm Hg (diastolic), and thus fell within the range of high normal or grade 1 hypertension.25 However, at the baseline assessment they were included if they satisfied either of these criteria (130–160 mm Hg systolic and/or 85–100 mm Hg diastolic). Exclusion criteria included BP measurements at baseline control outside the range of 120–180 (systolic) or 80–110 mm Hg (diastolic); that is, below the definitions for optimal or above those for grade 3 hypertension, respectively. Patients requiring ongoing adjustment of BP medication during the 4 weeks before baseline were also excluded. Patients with expected inability to understand instructions about the yoga exercises, physical or mental incapacity to carry out yoga exercises, or language problems/interpreter needs were also excluded. Aside from the above there were no medical exclusion criteria. The inclusion and exclusion criteria were established before study start.

A random sample of 2144 patients (computer-generated randomization list) was screened for eligibility by the lead investigator (MW). About half of the patients (1020) met the inclusion criteria and were invited by mail to participate in the study. After 2 weeks, they were contacted by telephone by a research assistant to provide further information about the study. Those who agreed to participate were invited for baseline assessment at their regular health-care centre. Baseline assessments and study questionnaires (WHOQOL-BREF, PSS-14, HADS and a health status and lifestyle survey) were completed after written informed consent was obtained from the participants. The physical assessments at baseline and follow-up were conducted by trained nurses and care assistants who remained blinded to group allocation throughout the study. After 12 weeks of intervention, all participants were reassessed for BP and questionnaires.

All patients (intervention and control group) were asked not to change their medication during the study, and any change in medication was registered at follow-up.


The yoga performed in the study is a form of Kundalini yoga (Mediyoga) developed at the Institute for Medical Yoga (IMY).17 The yoga programme used in the study takes about 15 min to perform and incorporates the following two exercises: (1) 'Left nostril breathing'—deep breaths in and out through the left nostril while sitting or lying down, with the right nostril closed off by the right thumb or a nose plug (duration about 11 min); and (2) 'spinal flex'—a movement that alternates between flexing the spine forwards (arching) and back in time with deep breaths while sitting on a chair or the edge of a bed (about 4 min). The same yoga programme was used in the YHIP study.16 The yoga exercises are listed in the Supplementary appendix.

Intervention group

The patients randomized to yoga (96 persons) received information and instructions concerning the two yoga exercises (provided in Supplementary appendix), during a single 30 min GP consultation. They were asked to perform these exercises for 15 min twice-daily (just after getting out of bed in the morning and just before going to bed in the evening). Patients who did not manage to perform the exercises in the correct way were obliged to quit the study. However, mediyoga is permissive, which means that the instructors do not correct the patients doing the exercises if not necessary. During the consultation, the patients also received a CD, a nose plug to use during the left nostril breathing exercise, a manual to facilitate their home exercises and a yoga diary in which to record details of when they had done yoga training. The participants were also able to listen to and download the audio-guided yoga programme to their smartphone or computer via a website specifically made for the study. The three doctors who conducted the study and were involved in the yoga teaching were employed at the respective health-care centre. Two of the doctors were trained mediyoga instructors; and the third doctor was a study physician who was not a trained yoga instructor but was familiar with the yoga exercises. The doctors were given instructions by the Mediyoga founder (Göran Boll) during a 2-h lecture. The patients, in turn, received information and instructions concerning the two yoga exercises from the doctor during a single 30 min GP consultation. If the patients did not manage to perform the exercises in the correct way, then they were obliged to quit the study. This did not happen to any of the participants. To make the doctor’s consultations as similar as possible between the centres, a common template was drafted and the template was then used during the visits.

Control group

No changes were made for the control group (95 persons), which received 'treatment as usual' (treatment with the medication they were already taking and annual medical examination by the GP).

Study measures

Data were collected at baseline and after completion of the 12-week intervention. The research assistants who collected the data were blinded to the group assignment.

BP was measured following the guidelines of the European Society of Hypertension,26 in a sitting position after 5–10 min of rest with validated electronic blood pressure devices (Omron 705-IT, Omron Health Care Co., Kyoto, Japan) using an appropriate sized cuff. All patients had their arm size measured by a nurse using a tape measure to ensure that the right cuff size was used. The mean of two readings was calculated (mean of three readings when the first and second readings differed by >5 mm Hg).

The WHOQOL-BREF is a validated QOL questionnaire containing 26 items, which measure the following four domains: physical health, psychological health, social relationships and environment.21 The first two items (WHO1 and WHO2) are so-called global items that can be analysed separately. They measure overall QOL and overall health satisfaction, respectively. Each individual item of the WHOQOL-BREF is scored from 1 to 5. Higher scores indicate better QOL.

The PSS-14 is a self-reported questionnaire that is designed to measure 'the degree to which individuals appraise situations in their lives as stressful'.22 The instrument is a 14-item scale with 7 positive items and 7 negative items rated on a 5-point Likert scale.

The HADS was originally developed to identify cases (possible and probable) of anxiety and depression among patients in non-psychiatric hospital clinics,23 but has since also been found to perform well in assessing outpatient populations.27 The scale consists of 14 items that can be divided into an Anxiety subscale (HADS-A) and a Depression subscale (HADS-D). Every single item is scored 0–3, where 0 means a low and 3 means a high level of anxiety or depression. Participants with a score on HADS-A or HADS-D of 8 or higher were classified as a case of anxiety or depression, respectively.

The health status and lifestyle survey was designed for this study and is not validated (provided in Supplementary appendix). The survey contained questions regarding comorbidity for diabetes and cardiovascular disease, smoking and drinking habits and physical activity.

On their yoga calendars, the participants marked with a cross each time they completed the yoga training. The information in the calendars was not validated or questioned.

Statistics/data analysis

Data were analysed using IBM SPSS Statistics 22 (IBM Corp. Released 2013, IBM SPSS Statistics for Windows, Version 22.0; IBM Corp., Armonk, NY, USA) and SAS 9.4 (SAS Institute, Cary, NC, USA). The analysis used an intention to treat approach. We also performed per protocol analyses. Differences in BP, QOL, stress and continuously measured HADS-A and HADS-D variables between baseline and follow-up were calculated by paired-samples Student’s t-test in each group (normally distributed data). Differences in mean change between the yoga and control groups were calculated by ANCOVA,28 with baseline values as covariates. For change in mean systolic blood pressure (SBP), we also used regression analysis with adjustment for age, sex and body mass index (BMI). For differences in change from baseline to follow-up in dichotomized HADS-A and HADS-D scores, we used a marginal model (generalized estimating equation) with robust errors,29 with a binomial distribution and log link (log-binomial model) and included an interaction between time of measurement and group to test whether there was an important change from baseline.


Figure 1 shows the flow of participants through the study. Of the 315 patients who attended the baseline assessment, 124 patients (39%) did not meet the inclusion criteria regarding BP, mainly due to optimal diastolic blood pressure (DBP) (<80 mm Hg, n=83, 67%). The sample of 191 participants consisted of 92 men and 99 women aged 34–79 years (mean age 64.7, s.d. 8.4). The baseline characteristics are presented in Table 1. A majority of the patients were overweight (BMI >25 kg m−2); and the criterion for central obesity was fulfilled for 67.7% of the women (88 cm) and for 55.4% of the men (102 cm). Less than one-third of the patients (29.4%) stated that they completed more than 1 h of vigorous exercise a week. None of the participants in the yoga group were excluded, because they were unable to perform the yoga exercises.

Figure 1

Flow chart outlining patient recruitment and the allocation of patients to different groups.

Table 1 Baseline characteristics

Effect of intervention on outcome measures

Table 2 shows the follow-up measures and adjusted changes for SBP and DBP. There were no significant differences in mean change of either SBP or DBP between the control and yoga groups. These results were stable after adjustment for sex, age, BMI, waist circumference, number of performed yoga sessions, number of BP-lowering medicines and level of anxiety, stress and depression or other comorbidities at baseline. We also did logistic regression looking at probability of reaching a BP reduction of at least 5 mm Hg. There were no indications that a specific subgroup would benefit more from the intervention. However, using within-group comparisons, both yoga and control group data demonstrated a significant decrease in SBP (−3.8±12.3 vs −4.5±12.1; P<0.05) and DBP (−1.7±7.1 vs −3.0±7.4; P<0.05).

Table 2 Mean BP after intervention and adjusted mean change in BP

Significant improvements were found in the yoga group for parts of the secondary outcome measure, namely regarding health satisfaction (WHO2, Table 3) and for the domains physical health (P<0.007), psychological health (P<0.039) and environment (P<0.026) (data provided in Supplementary appendix) compared with control. However, the global item for QOL (WHO1) did not improve in any of the groups, and there were no significant changes in the social relationships domain compared with control.

Table 3 Self-rated quality of life and health satisfaction after intervention and adjusted mean change

Data from the PSS and HADS assessments are shown in Table 4. There were no significant change in the PSS and continuous HADS-A scores compared with control, but there was a significant difference in the HADS-D score from baseline to follow-up between the yoga group compared with control (−0.9 (95% CI, −1.5 to −0.4), P=0.001). In total, 44 patients (23.2%) fulfilled the criteria for at least mild anxiety and 13 patients (6.8%) fulfilled the criteria for at least mild depression at baseline. However, despite a significant change in the continuous HADS-D score, when examined as defined cases there were no important differences between groups in change of the proportions fulfilling the criteria for depression (P=0.087).

Table 4 Scores on stress (PSS), anxiety (HADS-A) and depression (HADS-D) after intervention and adjusted mean change

The mean number of yoga sessions completions during the 12 weeks was 118.6 (that is, 1.4 yoga sessions/day), ranging from 3 to 195. The most cited reasons for barriers to compliance were lack of time/holiday (27 persons) and physical barriers such as illness/cold/stuffed nose (20 persons). Four patients withdrew during the intervention, and the reasons given for withdrawal were illness (n=1); felt stressed by doing the yoga (n=2); and no stated reason (n=1).

We also performed per protocol analyses through which patients who did not perform yoga for at least 9/12 weeks or who changed their medication were excluded, but there were no noticeable differences compared with the intention to treat analysis (data provided in Supplementary appendix 4). According to the yoga calendars, 75 of 96 participants in the yoga group did yoga at least 9/12 weeks (78%), 15 participants did yoga less frequently and 6 participants did not return their yoga calendars. This criterion (yoga at least 9/12 weeks) was set up together with the IMY founder, and it was not known to the patients.

At the follow-up assessment, intervention participants rated their physical and mental experience of the yoga intervention. Almost three quarters (73.9%, n=65) of the participants reported positive or very positive physical experience and 71.1% (n=62) reported positive or very positive mental experience of the yoga intervention. Forty-nine participants (56.3%) felt confident they would continue doing the yoga after study completion. The control participants were also able to rate their experience of taking part in the study, and 64 (74.4%) rated it as positive or very positive.

According to the lifestyle survey, there were no significant changes in level of physical activity during the intervention period either within or between the groups.

There were no serious adverse events reported by the yoga group participants.


We recorded no evidence that this yoga intervention (Mediyoga) decreased SBP or DBP in primary care patients with diagnosed hypertension more than usual care. However, both yoga and control groups had a significant within-group decrease in SBP and DBP. We found a small improvement in the HAD depression score (HADS-D) for the yoga group compared with control, although we could not demonstrate any significant reduction in the actual number of patients with depression. Significant improvements were also found for some of the QOL measures (health satisfaction, physical health, psychological health and environment).

Yoga is gaining popularity in the western world and an increasing number of patients are practicing yoga for health reasons. Several yoga reviews have stated the need for well-powered randomized studies to evaluate the effect of yoga on hypertension.12, 30, 31 Accordingly, our research group conducted a pilot study using the same yoga intervention, in which we demonstrated a significant BP reduction and a positive effect on QOL.16 In the present study, we increased the intervention from 15 min daily to 15 min twice-daily and we also increased the sample size from 83 to 191. Furthermore, the present study is a fully randomized clinical trial, whereas the pilot study was a matched controlled study. This study is also a three-centre study with three different therapists, which diminishes the risk of therapist’s bias. Thus, our conclusion is that the findings of the present study are more reliable, and that the results from the pilot study are more subject to confounding and bias.

There is indeed an increasing number of studies on the effects of yoga for numerous conditions. BP measurement is relatively easy and cheap to perform, and there are probably many studies with other main outcomes that include measurements of BP. However, if the results of the BP change are not positive, then they might well not be highlighted and difficult to find.32

However, a recent, large randomized controlled trial from India on the effectiveness of yoga in hypertensive patients, does report a very large reduction in BP.8 There are a number of differences to our study, which might contribute to the different result. The Indian study practices another form of yoga, and the intervention period started with an instructor-led intensive course for 5 days. The patients were younger (30–60 years) and were recruited by means of announcements on radios and newspaper which could have led to a selection bias. The participants of the Indian study also had a much stronger compliance than we found, with all participants in the yoga group (n=118) reporting 100% commitment to the yoga programme. Another Indian study from 2009, comparing slow and fast breathing yoga exercises to control in adults with grade 1 hypertension, showed a significant reduction in SBP and DBP for both breathing exercise groups.33 The exact sizes of the BP reduction for the two groups are not presented in the paper. The breathing exercises were taught during daily lessons for 14 consecutive work days, and the patients were then instructed to perform the programme at home 15 min twice-daily throughout the 3-month intervention period. A recent review on yoga trials showed that randomized controlled trials on yoga conducted in India have about 25 times the odds of reaching positive results.34 There could be several reasons for this finding. First, Indian yoga interventions are often more intense,35 which means that the BP reduction could be due to vigorous physical activity rather than the consequence of a specific yoga effect. It is also likely that Indian patients, being familiar with the spiritual and philosophical tradition of yoga, find it easier to incorporate yoga into daily life. The understanding of the spiritual part of yoga may also influence the impact that yoga can cause. Indian yoga instructors may well be more skilled and/or dedicated than yoga instructors from other countries, resulting in better outcomes. These differences make it difficult to generalize the effectiveness of Indian yoga trials to hypertensive patients in other countries.

Two American randomized controlled trials have evaluated yoga for pre-hypertensive and hypertensive patients, compared with active control groups.9, 10 In these studies, the change in BP was evaluated with 24 h ambulatory BP after 12 weeks of intervention, which is the most accurate method to detect BP change. Unfortunately, both studies were underpowered, with group sizes of around 30 patients. One of the studies also suffered from large dropout rates in the yoga group (20 of 46 randomized patients withdrew), causing a major selection bias.10 The interventions consisted of instructor-led yoga classes for at least 60 min weekly plus home practice. One study showed significant within-group reductions for both SBP and DBP, but these were not significant compared with control.10 The other study presented a significant within-group reduction for DBP that remained significant only for night time DBP in the between-group comparisons (−5.17±15.70 vs −0.85±15.80, P<0.038).9

One possible explanation for the lack of an additional BP reduction in the yoga group compared with control in our study could be that the participants in the yoga group considered doing yoga twice-daily too time consuming and stressful, and that this might have counteracted the BP reduction of the yoga intervention. Adherence to the yoga intervention was 78%, which indicates a fairly good compliance. However, since lack of time was the most cited barrier to adherence, yoga once-daily might have led to better compliance and a better effect. Compared with other yoga studies in OECD countries (Organization for Economic Co-operation and Development), the adherence to intervention was good.9, 10 It could also be that 12 weeks is a too short period to be able to detect the changes that the yoga intervention exerts. However, 12 weeks is a common duration for interventions in previous yoga studies.8, 9, 10, 33 In comparison with other yoga studies, our study differs by not offering formal yoga classes led by an instructor. Instead, the yoga was taught on one single occasion by a GP (with varying yoga teaching experience). At baseline, 26% of the yoga patients were well controlled (140/90 mm Hg) compared with 17% in the control group. As it is easier to lower a BP that is high, this could have contributed to the lack of BP reduction in the yoga group compared with control. On the other hand, mean BP values were equal between the groups at baseline; and SBP and DBP were normally distributed within the groups.

The study has a number of strengths. Primarily, this is the largest randomized controlled trial in the western world to date on yoga’s effect on BP with BP as the primary outcome. It also examined several other secondary outcomes. The study examined the effects of yoga in a primary health-care setting, where most patients with hypertension are treated. It is a three-centre trial, which diminishes the risk of therapists’ bias. On the other hand, we acknowledge that the study has a number of limitations. First, our study is limited to a single form of yoga. It may be that other schools of yoga or other yoga programmes have a better impact on BP and on the other outcomes. The self-reported data (yoga calendar) is a source of uncertainty, which is a problem in all studies of this kind. We only measured BP on two occasions during the 12-week intervention. Given that BP varies considerably within individuals over time, a 24-h ambulatory BP is the most accurate method to measure the patient’s actual BP and to avoid impact of white coat hypertension on the results.36 This is, however, time consuming and expensive, and requires a much larger effort from the participants, possibly causing more dropouts.

The findings of our study, which is the largest study from an OECD country to date, do not show that this yoga intervention (Mediyoga) lowers the BP compared with control. However, the patients in the yoga group had significant improvement regarding health satisfaction and depression measures. Further clinical trials are needed to confirm the effects of yoga on these outcomes.


  1. 1

    Chow CK, Teo KK, Rangarajan S, Islam S, Gupta R, Avezum et al. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA 2013; 310: 959–968.

    CAS  Article  Google Scholar 

  2. 2

    Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2013; 380: 2224–2260.

    Article  Google Scholar 

  3. 3

    Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2013; 380: 2095–2128.

    Article  Google Scholar 

  4. 4

    Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB et al. Executive summary: heart disease and stroke statistics—2012 update: a report from the American Heart Association. Circulation 2012; 125: 188–197.

    Article  Google Scholar 

  5. 5

    Hyman DJ, Pavlik VN . Self-reported hypertension treatment practices among primary care physicians: blood pressure thresholds, drug choices, and the role of guidelines and evidence-based medicine. Arch Intern Med 2000; 160: 2281–2286.

    CAS  Article  Google Scholar 

  6. 6

    National Center for Complementary and Integrative Health (NCCIH). Yoga. (Web page) 2015 [cited 2015 6 October] Available from

  7. 7

    Zhang Y . American Adult Yoga Practice: preliminary findings from NHIS 2012 data. J Altern Complement Med 2014; 20: A122 (Abstract).

    Article  Google Scholar 

  8. 8

    Sujatha T, Judie A . Effectiveness of a 12-week yoga program on physiopsychological parameters in patients with hypertension. Int J Pharm Clin Res 2014; 6: 329–335.

    Google Scholar 

  9. 9

    Hagins M, Rundle A, Consedine NS . Khalsa SBS. A randomized controlled trial comparing the effects of yoga with an active control on ambulatory blood pressure in individuals with prehypertension and stage 1 hypertension. J Clin Hypertens 2014; 16: 54–62.

    Article  Google Scholar 

  10. 10

    Cohen DL, Bloedon LT, Rothman RL, Farrar JT, Galantino ML, Volger S et al. Iyengar yoga versus enhanced usual care on blood pressure in patients with prehypertension to stage I hypertension: a randomized controlled trial. J Evid Based Complementary Altern Med 2011; 2011: 546428.

    Google Scholar 

  11. 11

    Cramer H, Haller H, Lauche R, Steckhan N, Michalsen A, Dobos G . A systematic review and meta-analysis of yoga for hypertension. Am J Hypertens 2014; 27: 1146–1151.

    CAS  Article  Google Scholar 

  12. 12

    Joseph CN, Porta C, Casucci G, Casiraghi N, Maffeis M, Rossi M et al. Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension. Hypertension 2005; 46: 714–718.

    CAS  Article  Google Scholar 

  13. 13

    Khattab K, Khattab AA, Ortak J, Richardt G, Bonnemeier H . Iyengar yoga increases cardiac parasympathetic nervous modulation among healthy yoga practitioners. Evid Based Complement Alternat Med 2007; 4: 511–517.

    Article  Google Scholar 

  14. 14

    Banasik J, Williams H, Haberman M, Blank SE, Bendel R . Effect of Iyengar yoga practice on fatigue and diurnal salivary cortisol concentration in breast cancer survivors. J Am Acad Nurse Pract 2011; 23: 135–142.

    Article  Google Scholar 

  15. 15

    Whitworth JA, Mangos GJ, Kelly JJ . Cushing, cortisol, and cardiovascular disease. Hypertension 2000; 36: 912–916.

    CAS  Article  Google Scholar 

  16. 16

    Wolff M, Sundquist K, Larsson Lonn S, Midlov P . Impact of yoga on blood pressure and quality of life in patients with hypertension - a controlled trial in primary care, matched for systolic blood pressure. BMC Cardiovasc Disord 2013; 13: 111.

    Article  Google Scholar 

  17. 17

    Mediyoga. (Web page) 2015 [cited 2015 6 October]. Available from

  18. 18

    Pan Y, Yang K, Wang Y, Zhang L, Liang H . Could yoga practice improve treatment-related side effects and quality of life for women with breast cancer? A systematic review and meta-analysis. Asia Pac J Clin Oncol (e-pub ahead of print 6 Jan 2015; doi: 10.1111/ajco.12329.

  19. 19

    Javnbakht M, Kenari RH, Ghasemi M . Effects of yoga on depression and anxiety of women. Complement Ther Clin Pract 2009; 15: 102–104.

    CAS  Article  Google Scholar 

  20. 20

    Pilkington K, Kirkwood G, Rampes H, Richardson J . Yoga for depression: the research evidence. J Affect Disord 2005; 89: 13–24.

    Article  Google Scholar 

  21. 21

    World Health Organization. WHOQOL-BREF: introduction, administration, scoring and generic version of the assessment: field trial version, December 1996. Available from

  22. 22

    Cohen S, Kamarck T, Mermelstein R . A global measure of perceived stress. J Health Soc Behav 1983; 24: 385–396.

    CAS  Article  Google Scholar 

  23. 23

    Zigmond AS, Snaith RP . The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67: 361–370.

    CAS  Article  Google Scholar 

  24. 24

    Schulz KF, Altman DG, Moher D and CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ 2010; 340: c332.

    Article  Google Scholar 

  25. 25

    Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013; 34: 2159–2219.

    Article  Google Scholar 

  26. 26

    O'Brien E, Asmar R, Beilin L, Imai Y, Mancia G, Mengden T et al. Practice guidelines of the European Society of Hypertension for clinic, ambulatory and self blood pressure measurement. J Hypertens 2005; 23: 697–701.

    CAS  Article  Google Scholar 

  27. 27

    Bjelland I, Dahl AA, Haug TT, Neckelmann D . The validity of the Hospital Anxiety and Depression Scale: an updated literature review. J Psychosom Res 2002; 52: 69–77.

    Article  Google Scholar 

  28. 28

    Vickers AJ, Altman DG . Analysing controlled trials with baseline and follow up measurements. BMJ 2001; 323: 1123–1124.

    CAS  Article  Google Scholar 

  29. 29

    Hanley JA, Negassa A, Forrester JE . Statistical analysis of correlated data using generalized estimating equations: an orientation. Am J Epidemiol 2003; 157: 364–375.

    Article  Google Scholar 

  30. 30

    Wang J, Xiong X, Liu W . Yoga for essential hypertension: a systematic review. PLoS ONE 2013; 8: e76357.

    CAS  Article  Google Scholar 

  31. 31

    Posadzki P, Cramer H, Kuzdzal A, Lee MS, Ernst E . Yoga for hypertension: a systematic review of randomized clinical trials. Complement Ther Med 2014; 22: 511–522.

    Article  Google Scholar 

  32. 32

    Chen KM, Fan JT, Wang HH, Wu SJ, Li CH, Lin HS . Silver yoga exercises improved physical fitness of transitional frail elders. Nurs Res 2010; 59: 364–370.

    Article  Google Scholar 

  33. 33

    Mourya M, Mahajan AS, Singh NP, Jain AK . Effect of slow-and fast-breathing exercises on autonomic functions in patients with essential hypertension. J Altern Complement Med 2009; 15: 711–717.

    Article  Google Scholar 

  34. 34

    Cramer H, Lauche R, Langhorst J, Dobos G . Are Indian yoga trials more likely to be positive than those from other countries? A systematic review of randomized controlled trials. Contemp Clin Trials 2015; 41C: 269–272.

    Article  Google Scholar 

  35. 35

    Cramer H, Lauche R, Langhorst J, Dobos G . Effectiveness of yoga for menopausal symptoms: a systematic review and meta-analysis of randomized controlled trials. Evid Based Complementary Altern Med 2012; 2012: 863905.

    Article  Google Scholar 

  36. 36

    Hodgkinson J, Mant J, Martin U, Guo B, Hobbs F, Deeks J et al. Relative effectiveness of clinic and home blood pressure monitoring compared with ambulatory blood pressure monitoring in diagnosis of hypertension: systematic review. BMJ 2011; 342: d3621.

    CAS  Article  Google Scholar 

Download references


We would like to thank the staff and management group at Löddeköpinge, Hjärup and Bara Primary Health Care Centres. A special thanks to general pracitioner Beata Borgström Bolmsjö and Camilla Richardson for their willingness to commit time and effort for the research on yoga and hypertension. We are grateful to Göran Boll, the founder of the IMY, who has provided inspiration, knowledge and educational materials. This study was funded by the Faculty of Medicine at Lund University, the Ekhaga Foundation, the Swedish Heart-Lung Foundation and the Swedish Southern Health Care Region, Agreement for Medical Education and Research (ALF) funding from Region Skåne and a Swedish Research Council grant awarded to Kristina Sundquist.

Author information



Corresponding author

Correspondence to M Wolff.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies this paper on the Journal of Human Hypertension website

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wolff, M., Rogers, K., Erdal, B. et al. Impact of a short home-based yoga programme on blood pressure in patients with hypertension: a randomized controlled trial in primary care. J Hum Hypertens 30, 599–605 (2016).

Download citation

Further reading


Quick links