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Effects of established blood pressure loci on blood pressure values and hypertension risk in an Algerian population sample

Journal of Human Hypertension volume 29, pages 296–302 (2015)Cite this article

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Abstract

Genome-wide association studies and subsequent replication studies have pinpointed 29 genetic variants associated with blood pressure (BP). None of these studies included North African populations. We therefore looked at whether or not these genetic variants modulated BP and hypertension (HTN) risk in an Algerian population sample. Twenty-nine single-nucleotide polymorphisms (SNPs) were genotyped in a representative sample of 787 subjects from the InSulino-résistance à ORan (ISOR) study (378 men and 409 women aged between 30 and 64 years and recruited from within the city of Oran, Algeria). Genetic variants were considered both individually and when combined as genetic predisposition scores (GPSs) for systolic BP (SBP), diastolic BP (DBP) and HTN risk. The SNPs in CYP1A1-ULK3, HFE and SH2B3 were significantly associated with BP and/or HTN. The SBP-GPS, DBP-GPS and HTN-GPS were associated with higher levels of DBP (+0.24 mm Hg P=0.05, +0.23 mm Hg P=0.05 and +0.26 mm Hg P=0.03, respectively). Moreover, the three GPSs tended to be associated with a 6% higher risk of HTN. Our study is the first to show that some of the BP loci validated in subjects of European descent were associated (either individually or when combined as GPSs) with BP traits and/or the HTN risk in an Algerian population, but to a lesser extent than in European populations. Although larger studies and meta-analyses of North African populations are needed to confirm the present results, our data contribute to a better understanding of genetic susceptibility to HTN.

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Acknowledgements

The ISOR project was funded through a collaboration agreement between the Direction de la Post-Graduation et de la Recherche-Formation (Algeria) and the Institut National de la Santé et de la Recherche Médicale (INSERM) (France). The work in France was also part-funded by INSERM. The work in Algeria was also part-funded by the Agence Thématique de Recherche en Sciences de la Santé and a grant from the Projets Nationaux de Recherche program run by the Algerian Direction Générale de la Recherche Scientifique et du Développement Technologique/Ministère de l’Enseignement Supérieur et de la Recherche Scientifique.

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Authors and Affiliations

  1. Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria

    S A Lardjam-Hetraf, S Mediene-Benchekor, H Ouhaibi-Djellouli, D N Meroufel, H Boulenouar, N Saidi-Mehtar & L Houti

  2. Département de Biotechnologie, Faculté des sciences de la Nature et de la Vie, Université d’Oran, Oran, Algeria

    S Mediene-Benchekor & H Ouhaibi-Djellouli

  3. INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France

    X Hermant, P Amouyel, L Goumidi & A Meirhaeghe

  4. Caisse Nationale des Assurances Sociales des travailleurs salariés, Clinique Spécialisée en Orthopédie et Rééducation des Victimes des Accidents de Travail, Oran, Algeria

    I Hamani-Medjaoui

  5. Faculté de Médecine, Université Djillali Liabes de Sidi Bel Abbès, Sidi Bel Abbès, Algeria

    L Houti

  6. Laboratoire des Systèmes d'Information en Santé, Université d’Oran, Oran, Algeria

    L Houti

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  1. S A Lardjam-Hetraf
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  5. H Boulenouar
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  9. P Amouyel
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Correspondence to A Meirhaeghe.

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Lardjam-Hetraf, S., Mediene-Benchekor, S., Ouhaibi-Djellouli, H. et al. Effects of established blood pressure loci on blood pressure values and hypertension risk in an Algerian population sample. J Hum Hypertens 29, 296–302 (2015). https://doi.org/10.1038/jhh.2014.81

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