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Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise

Journal of Human Hypertension volume 29, pages 53–57 (2015)Cite this article

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Abstract

Obesity-related hypertension is associated with increased activity of the renin-angiotensin-aldosterone system (RAAS), increasing arterial stiffness. Aerobic exercise decreases pulse wave velocity (PWV), therefore a treatment option for hypertension and obesity. Assess RAAS activity and PWV before and after 4 weeks of aerobic training in unmedicated, pre-to-stage-1 hypertensives. Ten obese subjects (52±3.2 years, body mass index=33.5±1.4) performed 30 min of aerobic exercise on a treadmill 3 days per week at 65% of peak oxygen consumption (VO2peak). Descriptive characteristics, systolic and diastolic blood pressure (SBP and DBP), PWV, and a blood draw was performed at baseline, following the 4-week control and training interventions. No differences in descriptive characteristics during the control period were observed, however, a significant decrease in plasma aldosterone (ALDO) (255.4±75 to 215.8±66 pg ml−1, P=0.001), SBP (140±12 to 136±10.4 mm Hg; P=0.02), DBP (89±4.2 to 85±6.3 mm Hg; P=0.03) and central PWV (11.2±0.6 to 9.8±0.8 m s−1; P=0.04) was shown pre-to-post exercise training. Four weeks of moderate-intensity aerobic training in obese, hypertensives decreases plasma ALDO independently of body weight and is significantly correlated to decreases in PWV reductions.

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Authors and Affiliations

  1. Department of Health Leisure and Exercise Science, Vascular Biology and Autonomic Studies Laboratory, Appalachian State University, Boone, NC, USA

    S R Collier, A M Moody & C D Curry

  2. Department of Medicine, Center for the Study of Sex Differences in Health, Aging and Disease, Georgetown University Medical Center, Washington DC, USA

    K Sandberg & H Ji

  3. Department of Medicine, Upstate Medical University, Syracuse, NY, USA

    V Frechette, R Gowdar & D Chaudhuri

  4. Department of Movement, University of Rome ‘Foro Italico’, Human and Health Sciences, Rome, Italy

    M Meucci

Authors
  1. S R Collier
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  2. K Sandberg
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  4. V Frechette
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Correspondence to S R Collier.

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Collier, S., Sandberg, K., Moody, A. et al. Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise. J Hum Hypertens 29, 53–57 (2015). https://doi.org/10.1038/jhh.2014.33

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