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Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension 2008; 51 (6): 1403–1419.
Egan BM, Zhao Y, Axon RN, Brzezinski WA, Ferdinand KC . Uncontrolled and apparent treatment resistant hypertension in the United States, 1988–2008. Circulation 2011; 124: 1046–1058.
Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM et al. Heart disease and stroke statistics—2011 update: a report from the American Heart Association. Circulation 2011; 123: e18–e209.
de la Sierra A, Segura J, Banegas JR, Gorostidi M, de la Cruz JJ, Amario P et al. Clinical features of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring. Hypertension 2011; 57: 898–902.
Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation 2012; 125: 1635–1642.
Florczak E, Szwench E, Śliwiński P, Bieleń P, Klisiewicz A, Michałowska I et al. Clinical characteristics of patients with resistant hypertension. J Human Hypertens 2013; 27 (11): 678–685.
Logan AG, Perlikowski SM, Mente A, Tisler A, Tkacova R, Niroumand M et al. High prevalence of unrecognized sleep apnea in drug-resistant hypertension. J Hypertens 2001; 19: 2271–2277.
Gonzaga CC, Gaddam KK, Ahmed MI, Pimenta E, Thomas SJ, Harding SM et al. Severity of obstructive sleep apnea is related to aldosterone status in subjects with resistant hypertension. J Clin Sleep Med 2010; 6 (4): 363–368.
Conn JW . Hypertension, the potassium ion and impaired carbohydrate tolerance. N Engl J Med 1965; 273: 1135–1143.
Fallo F, Veglio F, Bertello C, Sonino N, Della Mea P, Ermani M et al. Prevalence and characteristics of the metabolic syndrome in primary aldosteronism. J Clin Endocrinol Metab 2006; 91 (2): 454–459.
Fallo F, Pilon C, Urbanet R . Primary aldosteronism and metabolic syndrome. Horm Metab Res 2012; 44: 208–214.
Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS . Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 2002; 165: 670–676.
Rossi GP, Belfiore A, Bernini G, Fabris B, Caridi G, Ferri C et al. Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients. J Clin Endocrinol Metab 2008; 93: 2566–2571.
Goodfriend TL, Kelley DE, Goodpaster BH, Winters SJ . Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. Obes Res 1999; 7: 355–362.
Calhoun DA, Sharma K . The role of aldosteronism in causing obesity-related cardiovascular risk. Cardiol Clin 2010; 28 (3): 517–527.
Tuck ML, Sowers J, Dornfeld L, Kledzik G, Maxwell M . The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients. N Engl J Med 1981; 304: 930–933.
Sim JJ, Yan EH, Liu IL, Rasgon SA, Kalantar-Zadeh K, Calhoun DA et al. Positive relationship of sleep apnea to hyperaldosteronism in an ethnically diverse population. J Hypertens 2011; 29 (8): 1553–1559.
Swatikova A, Olson Lj, Wolk R, Phillips BG, Adachi T, Schwartz GL et al. Obstructive sleep apnea and aldosterone. Sleep 2009; 32: 1589–1592.
This work was supported by the following grants: RO1-HL79040 and CCTS 5UL1 RR025777.
The authors declare no conflict of interest.
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Dudenbostel, T. Resistant hypertension—complex mix of secondary causes and comorbidities. J Hum Hypertens 28, 1–2 (2014). https://doi.org/10.1038/jhh.2013.46