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Association of the G-protein β3 subunit gene polymorphism with the incidence of cardiovascular disease independent of hypertension: the Funagata study

Journal of Human Hypertension volume 27, pages 612–616 (2013)Cite this article

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Abstract

Association of the C825T G-protein β3 subunit (GNB3) gene polymorphism with cardiovascular disease (CVD) incidence was examined in a population-based longitudinal study of the Japanese individuals. The incidence of CVD (stroke and coronary heart disease (CHD)) was assessed in a cohort population (n=1524) consisting of participants of the 2001–2005 Funagata study through March 2008. Cumulative incidences according to genotype were compared with the Kaplan–Meier product-limit method. During the follow-up, 78 subjects experienced a CVD event (stroke: n=54; CHD: n=30; both consecutively: n=6). At the end of the follow-up (longest and median follow-up periods: 81 and 68 months, respectively), the cumulative incidence of CVD for the TT genotype was significantly higher than that of the C-carriers (0.077 vs 0.042, P=0.004). Blood pressures and the prevalence of hypertension were not different between the genotypes. Cox’s proportional hazard analysis showed that the TT genotype is a significant risk factor for CVD (hazard ratio (HR)=1.82 (95% confidence interval (CI) 1.14–2.89); P=0.012) and stroke (HR=1.76 (95% CI: 1.01–3.07); P=0.048) incidences after adjustment for age, sex, hypertension, hyperlipidemia, diabetes, alcohol drinking and smoking at baseline. The TT genotype of the C825T GNB3 gene polymorphism was found to be a significant risk factor for the incidence of CVD and stroke independent of hypertension and other established CVD risk factors in a Japanese population.

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Acknowledgements

This work was supported, in part, by the Global Center of Excellence Program (no. F03) of the Japan Society for the Promotion of Science (Japan) and Health Sciences Research Grants (H23-seishuu-005) from the Ministry of Health, Labour and Welfare of Japan.

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Authors and Affiliations

  1. Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine, Yamagata, Japan

    M Daimon, H Sato, W Kaino, K Tada, K Takase, S Karasawa, K Wada, W Kameda, S Susa, T Oizumi & T Kato

  2. Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan

    M Daimon, T Kayama & T Kato

  3. HuBit Genomix Research Institute, Tokyo, Japan

    H Sato & M Muramatsu

  4. Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    M Muramatsu

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  1. M Daimon
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Correspondence to M Daimon.

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Daimon, M., Sato, H., Kaino, W. et al. Association of the G-protein β3 subunit gene polymorphism with the incidence of cardiovascular disease independent of hypertension: the Funagata study. J Hum Hypertens 27, 612–616 (2013). https://doi.org/10.1038/jhh.2013.28

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