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Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs genetic polymorphisms and plasma levels in hypertensive disorders of pregnancy

Journal of Human Hypertension volume 27, pages 278–279 (2013)Cite this article

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Karthikeyan et al.1 published an interesting review in this journal on the relevance of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) for hypertensive disorders of pregnancy (HDP) and its complications. They have concluded that failure of regulation of the MMP/TIMP system in controlling the extracellular matrix remodeling may lead to diverse pathology, such as gestational hypertension (GH) and preeclampsia (PE). We would like to contribute additional, supportive data regarding plasma and genetic alterations in the MMP/TIMP system in HDP2, 3, 4 (Table 1).

Table 1 Plasma MMPs and TIMPs levels in HDP
Full size table

Higher MMP-9 levels in GH2 are in agreement with our prior findings reporting elevated pro-MMP-9 in women with GH.5 Moreover, higher TIMP-1 levels were observed in GH and PE.2 However, no significant differences were observed in MMP-9/TIMP-1 ratios.2 Conversely, while we have not previously found significant differences in pro-MMP-2 and TIMP-2 levels in HDP,5 we recently reported higher MMP-2 and TIMP-2 concentrations in women with PE, but there were no differences in MMP-2/TIMP-2 ratios.3 In addition, we reported higher MMP-2 levels and MMP-2/TIMP-2 ratios in GH.3

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References

  1. Karthikeyan VJ, Lane DA, Beevers DG, Lip GYH, Blann AD . Matrix metalloproteinases and their tissue inhibitors in hypertension-related pregnancy complications. J Hum Hypertens 2013; 27 (2): 72–78.

    Article  CAS  Google Scholar 

  2. Palei ACT, Sandrim VC, Amaral LM, Machado JSR, Cavalli RC, Lacchini R et al. Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antiypertensive therapy responsiveness in hypertensive disorders of pregnancy. Pharmacogenomics J 2012; 12 (6): 489–498.

    Article  CAS  Google Scholar 

  3. Palei AC, Sandrim VC, Amaral LM, Machado JS, Cavalli RC, Duarte G et al. Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy. Exp Mol Pathol 2012; 92 (2): 217–221.

    Article  CAS  Google Scholar 

  4. Palei AC, Sandrim VC, Duarte G, Cavalli RC, Gerlach RF, Tanus-Santos JE . Matrix metalloproteinase (MMP)-9 genotypes and haplotypes in preeclampsia and gestational hypertension. Clin Chim Acta 2010; 411 (11-12): 874–877.

    Article  CAS  Google Scholar 

  5. Palei AC, Sandrim VC, Cavalli RC, Tanus-Santos JE . Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertension. Clin Biochem 2008; 41 (10-11): 875–880.

    Article  CAS  Google Scholar 

  6. Myers JE, Merchant SJ, Macleod M, Mires GJ, Baker PN, Davidge ST . MMP-2 levels are elevated in the plasma of women who subsequently develop preeclampsia. Hypertens Pregnancy 2005; 24 (2): 103–115.

    Article  CAS  Google Scholar 

  7. Montagnana M, Lippi G, Albiero A, Scevarolli S, Salvagno GL, Franchi M et al. Evaluation of metalloproteinases 2 and 9 and their inhibitors in physiologic and pre-eclamptic pregnancy. J Clin Lab Anal 2009; 23 (2): 88–92.

    Article  CAS  Google Scholar 

  8. Luizon MR, Sandrim VC, Palei ACT, Lacchini R, Cavalli RC, Duarte G et al. Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy. Hypertens Res 2012; 35 (9): 917–921.

    Article  CAS  Google Scholar 

  9. Luizon MR, Sandrim VC, Palei AC, Lacchini R, Cavalli RC, Duarte G et al. Matrix metalloproteinase (MMP)-9 and VEGF gene interaction models and MMP-9 plasma levels in preeclampsia and gestational hypertension. FASEB J 2012; 26, (abstract 848.3).

  10. Fontana V, Silva PS, Gerlach RF, Tanus-Santos JE . Circulating matrix metalloproteinases and their inhibitors in hypertension. Clin Chim Acta 2012; 413 (7-8): 656–662.

    Article  CAS  Google Scholar 

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Acknowledgements

This study was funded by the ‘Fundação de Amparo à Pesquisa do Estado de São Paulo’ (FAPESP-Brazil) and the ‘Conselho Nacional de Desenvolvimento Científico e Tecnológico’ (CNPq-Brazil).

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil

    M R Luizon, L M Amaral & A C T Palei

  2. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA

    A C T Palei

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  1. M R Luizon
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  2. L M Amaral
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Correspondence to A C T Palei.

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Luizon, M., Amaral, L. & Palei, A. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs genetic polymorphisms and plasma levels in hypertensive disorders of pregnancy. J Hum Hypertens 27, 278–279 (2013). https://doi.org/10.1038/jhh.2012.35

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