Abstract
Lifestyle modifications to reduce risk factors for cardiovascular diseases such as blood pressure (BP) and smoking have been emphasized. Fruits and vegetables may modify such risk factors. The major aim of this randomized, controlled trial was to investigate the effects of (1) kiwifruits and (2) an antioxidant-rich diet compared with (3) a control group on BP and platelet aggregation (that is, whole-blood platelet aggregation) after 8 weeks in male smokers (age 44–74 years, n=102). The kiwifruit group received 3 kiwifruits per day, whereas the antioxidant-rich diet group received a comprehensive combination of antioxidant-rich foods. In the kiwifruit group, reductions of 10 mm Hg in systolic BP and 9 mm Hg in diastolic BP were observed (P=0.019 and P=0.016 (change from baseline in the kiwifruit group compared with change from baseline in the control group)). In the antioxidant-rich diet group, a reduction of 10 mm Hg in systolic BP was observed among hypertensives (P=0.045). Additionally, a 15% reduction in platelet aggregation and an 11% reduction in angiotensin-converting enzyme activity was observed in the kiwifruit group (P=0.009 and P=0.034). No effects on these parameters were observed in the antioxidant-rich diet group. This study suggest that intake of kiwifruit may have beneficial effects on BP and platelet aggregation in male smokers.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Van HL, McCoin M, Kris-Etherton PM, Burke F, Carson JA, Champagne CM et al. The evidence for dietary prevention and treatment of cardiovascular disease. J Am Diet Assoc 2008; 108 (2): 287–331.
Willcox JK, Catignani GL, Lazarus S . Tomatoes and cardiovascular health. Crit Rev Food Sci Nutr 2003; 43 (1): 1–18.
Dohadwala MM, Vita JA . Grapes and cardiovascular disease. J Nutr 2009; 139 (9): 1788S–1793S.
Erlund I, Koli R, Alfthan G, Marniemi J, Puukka P, Mustonen P et al. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008; 87 (2): 323–331.
Ried K, Sullivan T, Fakler P, Frank OR, Stocks NP . Does chocolate reduce blood pressure? A meta-analysis. BMC Med 2010; 8 (1): 39.
Chang WH, Liu JF . Effects of kiwifruit consumption on serum lipid profiles and antioxidative status in hyperlipidemic subjects. Int J Food Sci Nutr 2009; 19: 1–8.
Duttaroy AK, Jorgensen A . Effects of kiwi fruit consumption on platelet aggregation and plasma lipids in healthy human volunteers. Platelets 2004; 15 (5): 287–292.
Tandon R, Sinha MK, Garg H, Khanna R, Khanna HD . Oxidative stress in patients with essential hypertension. Natl Med J India 2005; 18 (6): 297–299.
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2008; (2). CD007176.
Carlsen MH, Halvorsen BL, Holte K, Bøhn SK, Dragland S, Sampson L et al. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J 2010; 9: 3.
Karlsen A, Svendsen M, Seljeflot I, Sommernes MA, Sexton J, Brevik A et al. Compliance, tolerability and safety of two antioxidant-rich diets: a randomised controlled trial in male smokers. Br J Nutr 2011; 106 (4): 557–571.
Chavez J, Cano C, Souki A, Bermúdez V, Medina M, Ciszek A et al. Effect of cigarette smoking on the oxidant/antioxidant balance in healthy subjects. Am J Ther 2007; 14 (2): 189–193.
Virdis A, Giannarelli C, Neves MF, Taddei S, Ghiadoni L . Cigarette smoking and hypertension. Curr Pharm Des 2010; 16 (23): 2518–2525.
Lillegaard IT, Andersen LF . Validation of a pre-coded food diary with energy expenditure, comparison of under-reporters v. acceptable reporters. Br J Nutr 2005; 94 (6): 998–1003.
Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G et al. 2007 Guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2007; 28 (12): 1462–1536.
Law MR, Morris JK, Wald NJ . Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009; 338: b1665.
Chen CH, Lin JY, Lin CN, Hsu SY . Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum. J Nat Prod 1992; 55 (5): 691–695.
Jung KA, Song TC, Han D, Kim IH, Kim YE, Lee CH . Cardiovascular protective properties of kiwifruit extracts in vitro. Biol Pharm Bull 2005; 28 (9): 1782–1785.
Lacaille D, Franck U, Wagner H . Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants. Phytomedicine 2001; 8 (1): 47–52.
Persson IA, Persson K, Andersson RG . Effect of Vaccinium myrtillus and its polyphenols on angiotensin-converting enzyme activity in human endothelial cells. J Agric Food Chem 2009; 57 (11): 4626–4629.
Heran BS, Wong MM, Heran IK, Wright JM . Blood pressure lowering efficacy of angiotensin converting enzyme (ACE) inhibitors for primary hypertension. Cochrane Database Syst Rev 2008; (4): CD003823.
Park YS, Jung ST, Kang SG, Drzewiecki J, Namiesnik J, Haruenkit R et al. In vitro studies of polyphenols, antioxidants and other dietary indices in kiwifruit (Actinidia deliciosa). Int J Food Sci Nutr 2006; 57 (1–2): 107–122.
Szeto YT, Tomlinson B, Benzie IF . Total antioxidant and ascorbic acid content of fresh fruits and vegetables: implications for dietary planning and food preservation. Br J Nutr 2002; 87 (1): 55–59.
Angiolillo DJ, Guzman LA, Bass TA . Current antiplatelet therapies: benefits and limitations. Am Heart J 2008; 156 (2 Suppl): S3–S9.
Skowasch D, Viktor A, Schneider-Schmitt M, Luderitz B, Nickenig G, Bauriedel G . Differential antiplatelet effects of angiotensin converting enzyme inhibitors: comparison of ex vivo platelet aggregation in cardiovascular patients with ramipril, captopril and enalapril. Clin Res Cardiol 2006; 95 (4): 212–216.
Acknowledgements
Anne Randi Enget and Aud Jørgensen provided help in the laboratory; RB formulated the present hypothesis; MS and ST were responsible for inclusion of participants and their follow-up; CAD was responsible for handling of data on dietary intake; AK, IS and PL were responsible for statistical analysis; and AK was responsible for drafting the manuscript, which was revised and approved by all authors.
Sources of funding: This work was supported by The Throne Holst Foundation, The Norwegian Research Council and The Norwegian Cancer Society.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
RB and CAD have an interest in Bioindex AS (established by Birkeland Innovation, the Technology transfer office at the University of Oslo) and Vitas AS (established by the Oslo Innovation Center). Otherwise, the authors declare no potential conflict of interest.
Additional information
Supplementary Information accompanies the paper on the Journal of Human Hypertension website
Supplementary information
Rights and permissions
About this article
Cite this article
Karlsen, A., Svendsen, M., Seljeflot, I. et al. Kiwifruit decreases blood pressure and whole-blood platelet aggregation in male smokers. J Hum Hypertens 27, 126–130 (2013). https://doi.org/10.1038/jhh.2011.116
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/jhh.2011.116
Keywords
This article is cited by
-
The nutritional and health attributes of kiwifruit: a review
European Journal of Nutrition (2018)
-
The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: a food-based multicentre randomized controlled trial
BMC Cancer (2017)
-
Effects of the DASH diet on blood pressure in patients with and without metabolic syndrome: results from the DASH trial
Journal of Human Hypertension (2014)