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Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status

Journal of Human Hypertension volume 24, pages 545–551 (2010)Cite this article

Abstract

The objective of this study was to analyse the relationship between the ambulatory blood pressure (ABP) measurement and plasma adiponectin levels in a population-based cohort. Non-hypertensive, non-diabetics from the Oulu Project Elucidating Risk of Atherosclerosis cohort aged 40–60 years with ABP measurement available in 226 men and 236 women were analysed. ABP was recorded using the fully automatic SpaceLabs 90207 oscillometric unit. Plasma adiponectin concentrations were assayed using the enzyme-linked immunosorbent assay method. Without adjustment the highest plasma adiponectin tertile was associated with the lowest ABP and office BP measurements (P from 0.025 to P<0.001, respectively). Only the association of plasma adiponectin concentration with systolic ABP was independent of other conventional risk factors (age, body mass index (BMI), waist, gender, insulin sensitivity index, smoking and alcohol consumption) for hypertension (P=0.017). No association was observed between systolic dipping pattern and adiponectin level. The plasma high adiponectin concentration is independently associated with low daytime systolic ABP value. The mechanisms may include effects on endothelial function and the sympathetic nervous system.

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Acknowledgements

This study was supported by the Medical Council of the Academy of Finland and the Finnish Foundation for Cardiovascular Research. We acknowledge the excellent technical assistance of Ms Helena Kalliokoski, Ms Saija Kortetjärvi, Ms Sirpa Rannikko and Ms Liisa Mannermaa.

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  1. Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland

    R L Vasunta, Y A Kesäniemi & O Ukkola

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  1. R L Vasunta
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  3. O Ukkola
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Correspondence to O Ukkola.

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Vasunta, R., Kesäniemi, Y. & Ukkola, O. Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status. J Hum Hypertens 24, 545–551 (2010). https://doi.org/10.1038/jhh.2009.98

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