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A modified ambulatory arterial stiffness index is independently associated with all-cause mortality

Journal of Human Hypertension volume 22, pages 761–766 (2008)Cite this article

Abstract

Dependence of the ambulatory arterial stiffness index (AASI) on data scattering interferes with its potential clinical relevance. We assessed the correlates and all-cause mortality associations of a modified AASI (s-AASI). AASI was derived from the 24-h diastolic vs systolic blood pressure linear regression line, whereas s-AASI was derived by symmetric regression (bisecting the line of diastolic vs systolic and systolic vs diastolic). Of 2918 patients 55% were women; age was 56±16 years and body mass index was 27.3±4.5 kg/m2. Average 24-h ambulatory blood pressure was 138±16/78±10 mm Hg. Applying the modified method for calculating AASI yielded a different measure: the negative correlation between AASI and blood pressure dipping (r=−0.304, P<0.0001) was abolished (r=+0.223, P<0.0001), s-AASI was more dependent on age (r=0.266 vs r=0.089 for AASI), and prediction of all-cause mortality was enhanced; hazard ratio (95% confidence intervals) 1.17 (1.00–1.36) per 1 s.d. increase in s-AASI in the fully adjusted model as compared with 1.15 (0.97–1.36) for AASI.

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Acknowledgements

Itay Almog provided invaluable assistance in handling old data files. Part of this work was presented at the AHA-CHBPR 2007 meeting.

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Authors and Affiliations

  1. Nephrology and Hypertension Services, Hadassah—Hebrew University Medical Center, Jerusalem, Israel

    I Z Ben-Dov

  2. InterCure Ltd, Lod, Israel

    B Gavish

  3. Epidemiology Unit, Hadassah—Hebrew University Medical Center, Jerusalem, Israel

    J D Kark

  4. Internal Medicine Department Mount-Scopus Campus, Hadassah—Hebrew University Medical Center, Jerusalem, Israel

    J Mekler & M Bursztyn

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  1. I Z Ben-Dov
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  2. B Gavish
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  3. J D Kark
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  4. J Mekler
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  5. M Bursztyn
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Correspondence to I Z Ben-Dov.

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Ben-Dov, I., Gavish, B., Kark, J. et al. A modified ambulatory arterial stiffness index is independently associated with all-cause mortality. J Hum Hypertens 22, 761–766 (2008). https://doi.org/10.1038/jhh.2008.50

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