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Antihypertensive drug class and dyslipidemia: risk association among Chinese patients with uncomplicated hypertension

Journal of Human Hypertension volume 22, pages 648–651 (2008)Cite this article

Factors associated with dyslipidemia in Chinese patients with uncomplicated hypertension were investigated in 1139 patients who were newly prescribed a single antihypertensive drug in the public primary healthcare setting in Hong Kong, where their fasting lipid profiles were measured 4–16 weeks after the first prescription. Multivariate logistic regression showed that thiazide users were more likely (odds ratio (OR) 3.67, 95% CI 1.13, 11.88, P =0.030) to have adverse (⩾6.2 mmol/l) total cholesterol (TC) compared with drugs acting on the renin angiotensin system (RAS), but the absolute difference in mean TC between thiazide users and all patients was small (0.14 mmol/l), whereas advanced age and male gender were also associated with some aspects of dyslipidemia. Clinicians should be aware of the increased risk of dyslipidemia in these groups, but the mild dyslipidemic profile associated with thiazides should not in itself deter its use as a possible first-line antihypertensive agent among Chinese patients.

Dyslipidemia has been recognized as a strong predictor of cardiovascular disease.1 There is increasing evidence that dyslipidemia is associated with2 and possibly a causative factor in hypertension.3 Studies on the potential predictive factors of dyslipidemia among established hypertensive patients are few, and evidence on the possible relationship between antihypertensive drug classes and dyslipidemia is mixed.4, 5 To our knowledge there are few reports on the risk factors of dyslipidemia among hypertensive patients of Chinese ethnicity. This study examined the lipid profiles of Chinese hypertensive patients who were newly prescribed a single antihypertensive agent and evaluated the risk association between potential predictive factors and the occurrence of dyslipidemia.

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Authors and Affiliations

  1. School of Public Health and Department of Community and Family Medicine, Faculty of Medicine, Chinese University of Hong Kong 4/F, School of Public Health, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

    M C S Wong, J Y Jiang, M K Ali, S Griffiths & S W Mercer

  2. Hospital Authority, Hong Kong SAR. 11/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, NT, Hong Kong, China

    H Fung

  3. Division of Community-based Sciences, General Practice and Primary Care, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, UK

    S W Mercer

Authors
  1. M C S Wong
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  2. J Y Jiang
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  3. M K Ali
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  4. H Fung
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  5. S Griffiths
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  6. S W Mercer
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Correspondence to J Y Jiang.

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Supplementary Information accompanies the paper on the Journal of Human Hypertension website (http://www.nature.com/jhh)

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Wong, M., Jiang, J., Ali, M. et al. Antihypertensive drug class and dyslipidemia: risk association among Chinese patients with uncomplicated hypertension. J Hum Hypertens 22, 648–651 (2008). https://doi.org/10.1038/jhh.2008.46

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