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Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians

Journal of Human Hypertension volume 23, pages 113–121 (2009)Cite this article

Abstract

Epidemiologic studies suggest an independent positive association of elevated serum uric acid with essential hypertension. However, to date, limited information is available in the old population. In the present study, we included 832 unrelated Chinese nonagenarians/centenarians (269 men and 563 women; ranged in age from 90 to 108 years (mean, 94.6±4.0)). The mean serum uric acid level was 320 μmol l−1 (standard deviation 87 μmol l−1). After adjustment for age, body mass index, waist-to-hip ratio, smoking habits, tea habits, alcohol consumption, fasting plasma glucose, plasma lipids and serum creatinine, the odds ratio comparing the highest with lowest quartile of serum uric acid were 0.67 (95% confidence interval (CI), 0.33–1.21) and 1.36 (95% CI, 0.88–2.22) in men and women, respectively. When compared with normotensive subjects, we did not observe statistical higher serum uric acid levels in subjects with hypertension. In summary, we found that serum uric acid level is not directly correlated with hypertension among Chinese nonagenarians/centenarians.

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Acknowledgements

This work was supported by grants from the project of Science and Technology Bureau of Sichuan Province (2006Z09-006-4), Construction Fund for Subjects of West China Hospital of Sichuan University (XK05001). The authors thank the staff of the Department of Geriatrics Medicine, West China Hospital and Dujiangyan Hospital, and all participants (as well as their legal proxies) for their great contribution. Mr Guangjian Liu and Mr Wei Ji are also acknowledged for their statistics assistance.

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  1. Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

    Z Lu, B Dong, H Wu, T Chen, Y Zhang & J Wu

  2. Laboratory of Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

    H Xiao

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Correspondence to B Dong.

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Lu, Z., Dong, B., Wu, H. et al. Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians. J Hum Hypertens 23, 113–121 (2009). https://doi.org/10.1038/jhh.2008.104

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