Table 1 Association of 1q43 SNPs with uterine fibroids and BMI in European Americans enrolled in the NIEHS study

From: Confounding by linkage disequilibrium

      Uterine fibroids (UL), Pa BMI, Pb
Obs SNP Inter-SNP distance, base pair Gene Function BMI adjusted BMI unadjusted UL adjusted UL unadjusted
375 rs4391653   RGS7 Intronic 0.0063   0.0272 0.0245
416 rs4290050 57 222 RGS7 Intronic   0.0078   
417 rs4378194 19 RGS7 Intronic   0.0153   
418 rs2815842 229 RGS7 Intronic   0.0143   
644 rs2994976 225 065 RGS7-FH Intergenic   0.0482   
651 rs3014580 4859 RGS7-FH Intergenic   0.0457   
656 rs2994979 4046 Downstream FH Intronic 0.0050 0.0800   
658 rs11586971 1123 Downstream FH Intronic 0.0050    
659 rs12754512 51 Downstream FH Intronic 0.0050    
661 rs2994981 1967 downstream FH Intronic 0.0045    
662 rs12566016 460 downstream FH Intronic 0.0045    
663 rs10926494 204 downstream FH Intronic 0.0017    
673 rs2144 7176 Downstream FH Intronic 0.0014    
943 rs10802996 365 915 EXO1 5′-UTR   0.0075   
948 rs4149864 58 417 EXO1-MAP1LC3C Intergenic 0.0724 0.0274   
987 rs4150028 29 371 EXO1-MAP1LC3C Intergenic 0.0193    
1037 rs3845563 545 213 PLD5 Intronic   0.0016   
1292 rs10926736 10 854 PLD5 Intronic   0.0019   
1320 rs7531009 7558 PLD5 Intronic   0.0064 0.0098 0.0099
1335 rs10926756 208 978 Far upstream PLD5 Intergenic   0.0015   
1340 rs1039534 1531 Far upstream PLD5 Intergenic   0.0047   
1587 rs10754775 160 Far upstream PLD5 Intergenic   0.0047   
1600 rs6673294 1757 Far upstream PLD5 Intergenic   0.0043   
1602 rs10803075 493 Far upstream PLD5 Intergenic   0.0053   
1603 rs6679445 494 Far upstream PLD5 Intergenic   0.0014   
  1. Abbreviations: BMI, body mass index; FH, fumarate hydratase; PDL5, phospholipase D member 5; SNP, single nucleotide polymorphism; UL, uterine leiomyoma.
  2. aLogistic regression models adjusted for covariates (age, age at menarche, parity and physical activity).
  3. bGeneral linear models adjusted for the effects of age and physical activity. Note that only SNPs that showed significant levels of association with either the uterine fibroid or the BMI outcome or with both outcomes are shown.