Colocalization of human traits of potential relevance to uterine fibroids on chromosome 1q43. Genomic map of a 2 Mb-long interval spanning the fumarate hydratase (FH) gene locus and showing the position of specific microsatellite markers (vertical bars) and gene loci linked or associated with diseases or traits of relevance to hormone-dependent tumors such as uterine leiomyomas. Quebec Family Study (QFS); sex hormone-binding globulin (SHBG); HERITAGE (HERITAGE Family Study). The placement of the genes in the gene map shown above the plot and the coordinates show below were derived the Human Genome assembly 19. Arrows indicate the orientation of the genes and are drawn proportionally to the size of the genes. RGS7 (regulator of G-protein 7); FH (fumarate hydratase); KMO (kynurenine 3-monooxygenase); OPN3 (opsin 3); WDR64 (WD repeat domain 64); EXO1 (exonuclease 1); MAP1LC3C (microtubule-associated protein 1 light chain 3 gamma); PLD5 (phospholipase D family, member 5).