Table 1 Two-point log of odds (LOD) scores with microsatellite markers in the EDA gene region

From: A novel missense mutation in the EDA gene associated with X-linked recessive isolated hypodontia

Marker locus Physical positiona Marshfield map (cM)b LOD score at recombination fraction θ
0 0.05 0.1 0.2 0.3
Family A
 DXS8040 68163024 53.58 2.995 2.641 2.284 1.571 0.883
 DXS453 69364800 56.29 0.837 0.686 0.546 0.306 0.132
 DXS8107 69637956 55.75 2.995 2.621 2.246 1.511 0.824
 DXS8052 69729590 55.75 3.289 2.88 2.472 1.673 0.934
Family B
 DXS8040 68163024 53.58 2.354 2.046 1.736 1.126 0.588
 DXS453 69364800 56.29 2.224 1.917 1.609 1.005 0.479
 DXS8107 69637956 55.75 1.020 0.846 0.674 0.351 0.092
 DXS8052 69729590 55.75 2.650 2.326 1.995 1.336 0.742
  1. aSequence-based physical map distances in bases according to Build36.2 of the human reference sequence (International Human Genome Sequence Consortium 2001)
  2. bGender-averaged Kosambi map distance (cM) from the Marshfield genetic map (Broman et al. 1998). The EDA gene is located between markers DXS8040 and DXS453