Fig. 1 | Journal of Human Genetics

Fig. 1

From: A novel missense mutation in the EDA gene associated with X-linked recessive isolated hypodontia

Fig. 1

a Pedigrees of family A and family B segregating X-linked recessive incisor hypodontia. Affected males are indicated by filled squares, and carrier females are identified by circles with a dot in the center. b Schematic representation of congenitally missing teeth in available affected individuals showing the predominant incisor hypodontia phenotype. c Panoramic X-ray of a 14-year-old affected male (family B, ind. IV:9). Arrows indicate positions of missing teeth. d Deoxyribonucleic acid (DNA) sequence chromatograms from EDA exon 9 showing the different genotypes at position c.1091 (arrows) in three individuals from family B. A healthy male (ind. IV:3; upper panel), a female carrier (ind. IV:8; mid panel), and an affected male (ind. IV:9; lower panel)

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