Abstract

Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12.

Author information

Affiliations

  1. Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    • Hajime Nawata
    • , Noriyuki Sonoda
    • , Hirotaka Tsubouchi
    • , Toyoshi Inoguchi
    • , Toshihiko Yanase
    •  & Takashi Eto
  2. Department of Pathology, Research Institute, International Medical Center, Tokyo, Japan

    • Senji Shirasawa
    •  & Mayuko Ishikawa
  3. Department of Medical Informatics, Kyushu University Hospital, Fukuoka, Japan

    • Naoki Nakashima
  4. Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan

    • Eiichi Araki
    •  & Takeshi Nishikawa
  5. Tenposan Clinic, Kagoshima, Japan

    • Jun Hashiguchi
  6. Sasebo Central Hospital, Nagasaki, Japan

    • Seibei Miyake
  7. Yukuhashi Central Hospital, Fukuoka, Japan

    • Teruaki Yamauchi
  8. Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita, Japan

    • Kazuyuki Hamaguchi
    •  & Hironobu Yoshimatsu
  9. Yatsushiro General Hospital, Kumamoto, Japan

    • Haruo Takeda
  10. Public Tamana Central Hospital, Kumamoto, Japan

    • Hideo Fukushima
  11. Omuta Tenryo Hospital, Fukuoka, Japan

    • Takayuki Sasahara
  12. Oita Prefectural Hospital, Oita, Japan

    • Kohei Yamaguchi
  13. Sonoda Clicin, Kagoshima, Japan

    • Tomoko Sonoda
  14. Kitakyushu Municipal Medical Center, Fukuoka, Japan

    • Masahiro Matsumoto
  15. First Department of Internal Medicine, School of Medicine, University of Occupational & Environmental Health, Fukuoka, Japan

    • Yoshiya Tanaka
  16. Sugimoto Clinic, Fukuoka, Japan

    • Hidekatsu Sugimoto
  17. National Health Insurance Takachiho Town Hospital, Miyazaki, Japan

    • Nakayasu Wake
  18. Narazaki Clinic, Fukuoka, Japan

    • Kenziro Narazaki
  19. Diabetology and Endocrinology Division of Internal Medicine, Fukuoka Medical Association Hospital, Fukuoka, Japan

    • Fumio Umeda
  20. Department of Cardiovascular, Respiratory & Metabolic Medicine Graduate School of Medicine, Kagoshima University, Kagoshima, Japan

    • Mitsuhiro Nakazaki
  21. Department of Laboratory Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

    • Junko Ono
  22. First Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan

    • Takashi Asano
  23. Furugou Clinic, Oita, Japan

    • Yasuko Ito
  24. Shin-Koga Hospital, Fukuoka, Japan

    • Shoichi Akazawa
  25. Kamiamakusa General Hospital, Kumamoto, Japan

    • Iwaho Hazegawa
  26. Department of Endocrinology and Metabolism, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan

    • Nobuyuki Takasu
  27. National Health Insurance Matsubase Town Hospital, Kumamoto, Japan

    • Moritsugu Shinohara
  28. Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    • Seiho Nagafuchi
  29. Shin-Kokura Hospital, Fukuoka, Japan

    • Toshimitsu Okeda
  30. First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

    • Katsumi Eguchi
  31. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    • Masanori Iwase
  32. Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

    • Masayuki Aoki
    •  & Ken Yamamoto
  33. Research Institute, International Medical Center of Japan, Tokyo, Japan

    • Naoto Keicho
    • , Norihiro Kato
    •  & Kazuki Yasuda
  34. International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan

    • Takehiko Sasazuki

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Corresponding author

Correspondence to Takehiko Sasazuki.

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1007/s10038-004-0199-3

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