Original Article | Published:

Catalog of 668 SNPs detected among 31 genes encoding potential drug targets on the cell surface

Journal of Human Genetics volume 48, pages 2346 (2003) | Download Citation

Abstract

We have been publishing a series of detailed maps of single-nucleotide polymorphisms (SNPs) detected within the genomic loci of 145 genes encoding drug-metabolizing enzymes and transporters. As an addition to the maps reported earlier, we provide here high-density SNP maps of 31 genes encoding various receptors and adhesion molecules of medical importance. By examining a total of approximately 382kb of genomic DNA encompassing these 31 genes, we identified 668 SNPs among 48 healthy Japanese individuals: 86 in 5′ flanking regions, 27 in 5′ untranslated regions, 45 in coding regions, 399 in introns, 47 in 3′ untranslated regions, and 64 in 3′ flanking regions. We also discovered 113 variations of other types. Of the 668 SNPs, 371 (55.5%) appeared to be novel, on the basis of comparisons with the dbSNP database of the National Center for Biotechnology Information (US) or with previous publications. The maps constructed in this study will serve as an additional resource for studies of complex genetic diseases and drug-response phenotypes to be mapped by linkage-disequilibrium analyses.

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Affiliations

  1. Laboratory for Genotyping, RIKEN SNP Research Center, c/o RIKEN Yokohama Institute, Yokohama, Japan

    • Aritoshi Iida
    • , Susumu Saito
    • , Akihiro Sekine
    • , Chihiro Mishima
    • , Yuri Kitamura
    • , Kimie Kondo
    • , Satoko Harigae
    • , Saori Osawa
    •  & Yusuke Nakamura
  2. Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

    • Yusuke Nakamura

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Corresponding author

Correspondence to Yusuke Nakamura.

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DOI

https://doi.org/10.1007/s100380300004

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