Original Article | Published:

906 variations among 27 genes encoding cytochrome P450 (CYP) enzymes and aldehyde dehydrogenases (ALDHs) in the Japanese population

Journal of Human Genetics volume 47, pages 419444 (2002) | Download Citation

Abstract

We screened DNAs from 48 Japanese individuals for single-nucleotide polymorphisms (SNPs) in genes encoding 13 cytochrome P450 (CYP) enzymes and 14 aldehyde dehydrogenases (ALDHs) by directly sequencing their entire genomic regions except for repetitive elements. This approach identified 810 SNPs and 96 insertion/deletion polymorphisms among the 27 genes. Of the 810 SNPs, 229 were identified among the CYP genes and 581 in the ALDH genes; of the total, 48 SNPs were located in 5′ flanking regions, 619 in introns, 91 in exons, and 52 in 3′ flanking regions. These variants should contribute to studies designed to investigate possible correlations between genotypes and phenotypes of disease susceptibility or responsiveness to drug therapy.

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Affiliations

  1. Laboratory for Genotyping, SNP Research Center, Institute of Physical and Chemical Research, Tokyo, Japan

    • Susumu Saito
    • , Aritoshi Iida
    • , Akihiro Sekine
    • , Chie Ogawa
    • , Saori Kawauchi
    • , Shoko Higuchi
    • , Machi Ohno
    •  & Yusuke Nakamura
  2. Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

    • Yusuke Nakamura

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Corresponding author

Correspondence to Yusuke Nakamura.

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DOI

https://doi.org/10.1007/s100380200061

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