Abstract
Calcium-sensing receptor (CASR) in parathyroid gland regulates calcium homeostasis by sensing decreases in extracellular calcium levels and effecting an increase in secretion of parathyroid hormone. A polymorphic dinucleotide (CA) sequence was isolated from a genomic clone containing the human CASR gene and was mapped to 3q13.3–q21. This polymorphism will be useful in the genetic study of disorders affecting calcium metabolism, such as hypercalcemia, hypocalcemia, osteoporosis, hyperparathyroidism, and hypoparathyroidism.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Additional information
Received: June 2, 1998 / Accepted: June 24, 1998
Rights and permissions
About this article
Cite this article
Tsukamoto, K., Watanabe, I., Shiba, T. et al. Isolation and radiation hybrid mapping of a dinucleotide repeat polymorphism at the human calcium-sensing receptor (CASR) locus. J Hum Genet 43, 280–282 (1998). https://doi.org/10.1007/s100380050091
Published:
Issue Date:
DOI: https://doi.org/10.1007/s100380050091