Summary
We reported on two patients with ade novo marker chromosome of which the origins were successfully identified by FISH using microdissected probes. These probes were established by microdis-sections of extra chromosomal segments from Carnoy-fixed cells stored at −20°C for several years. Using these probes, we could verify partial 1q32 trisomy in a patient with 17p+ as well as partial 16q2 trisomy in another patient with 4p+.
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Chinen, Y., Tohma, T., Izumikawa, Y. et al. Characterization of marker chromosomes by fish using microdissected probes from old carnoy-fixed cells: Report of two cases. Jap J Human Genet 42, 543–549 (1997). https://doi.org/10.1007/BF02767032
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DOI: https://doi.org/10.1007/BF02767032