Summary
This study was performed to investigate whether the apolipo-protein (apo) E4 allele is associated with hypercholesterolemia in Japanese male adults in large cities. The apo E phenotypes and serum lipid levels were analyzed on 142 apparently healthy male civil servants working in Tokyo. The prevalence of hypercholesterolemia (serum total cholesterol levels>250 mg/dl) were 4.7% in 106 apo E4-absent subjects and 19.4% in 36 apo E4-present subjects (p=0.012). The prevalence of hypercholesterolemia were 5.3% in 94 subjects with the apo E3/3 phenotype and 20.0% in 30 subjects with the apo E3/4 phenotype (p=0.023). In addition, mean serum total cholesterol levels were significantly higher in the apo E4-present subjects than in the apo E4-absent subjects (213±29.1versus 199±36.0, p<0.05). The data suggest that the apo E4 allele is associated with hypercholesterolemia in Japanese male adults working in large cities.
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Tsuchiya, S., Yamanouchi, Y., Miyazaki, R. et al. Association of the apolipoprotein E4 allele with hypercholesterolemia in apparently healthy male adults in Tokyo. Jap J Human Genet 32, 283–289 (1987). https://doi.org/10.1007/BF01910283
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DOI: https://doi.org/10.1007/BF01910283