Interstitial pulmonary fibrosis in two sisters. possible autosomal recessive inheritance

Summary

A 4-year-old girl and her 2-year-old sister both had interstitial pulmonary fibrosis. The parents, unrelated, were free from pulmonary fibrosis as judged from their chest radiographs and pulmonary function tests. The occurrence of the disease in daughters of apparently healthy parents suggests autosomal recessive inheritance, although dominant inheritance with a parent yet to develop the disease can not be totally ruled out.

References

  1. Davies, G.M., and Potts, M.W. 1964. Chronic diffuse interstitial pulmonary fibrosis in brothers.Guy's Hosp. Rep. 113: 36–44.

    CAS  Google Scholar 

  2. Donohue, W.L., Laski, B., Uchida, I., and Munn, J.D. 1959. Familial fibrocystic pulmonary dysplasia and its relation to the Hamman-Rich syndrome.Pediatrics 24: 786–813.

    CAS  PubMed  Google Scholar 

  3. McKusick, V.A. 1978.Mendelian Inheritance in Man. Catalogs of Autosomal Dominant, Autosomal Recessive, and X-Linked Phenotypes, 5th ed., The Johns Hopkins Univ. Press, Baltimore, pp. 336–337.

    Google Scholar 

  4. Stemmermann, G.N. 1966. Chronic familial lung disease.Am. Rev. Resp. Dis. 95: 663–669.

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tsukahara, M., Kajii, T. Interstitial pulmonary fibrosis in two sisters. possible autosomal recessive inheritance. Jap J Human Genet 28, 263–267 (1983). https://doi.org/10.1007/BF01876789

Download citation

Keywords

  • Cancer Research
  • Pulmonary Function
  • Chest Radiograph
  • Pulmonary Fibrosis
  • Pulmonary Function Test

Further reading