Summary
The polymorphism of the Group Specific Component (Gc) was studied in serum samples from a Fula population of Senegal (Western Africa) using isoelectric focusing in slab polyacrylamide gel followed by immunofixation. The isoelectric focusing patterns of various Gc phenotypes were compared to the patterns obtained by polyacrylamide disc electrophoresis. Besides the two subtypes,Gc 1F andGc 1S ofGc 1 and theGc Ab gene, aGc 1 variant and aGc 2 variant were discovered and namedGc 1b andGc 2b respectively. The results were compared to the data obtained in a Pygmy population. They confirmed the high degree of polymorphism of the Gc protein in African populations.
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Constans, J., Viau, M., Pison, G. et al. Gc subtypes demonstrated by isoelectric focusing: Further data and description of new variants among an African sample (Fula) from Senegal. Jap J Human Genet 23, 111–117 (1978). https://doi.org/10.1007/BF02001791
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DOI: https://doi.org/10.1007/BF02001791
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