Discrimination of Down's syndrome with dermatoglyphic examination: An application of two dimensional graphic representation

Summary

A method to discriminate Down's syndrome is proposed by the author by applying a two dimensional representation to the dermatoglyphic examination. For the parameters of this method, seven dermatoglyphic traits were selected,i.e. the type of hallucal pattern and the pattern type of index finger on both side, and the simian line, the maximalatd angle larger than 56° and the third interdigital patten on the right palm. These traits were transformed into a vector in order to illustrate an individual on a two dimensional plane.

For each dermatoglyphic trait a certain length of weight was give and a certain angle was settled for each characteristic of the trait. Then, the coordinate point, the product of vectors derived from these traits, was plotted on the plane for individuals examined. The procedure is represented by the following formulas:

$$\sum\limits_{j = 1}^7 {W_j cos \alpha _j , } \sum\limits_{j = 1}^7 {W_j sin \alpha _j } $$
((1))
$$\sum\limits_{j = 1}^7 {W_j = 1, } W_j \geqq 0$$
((2))

This procedure was applied for dermatoglyphic data of 140 patients with Down's syndrome (131 cases of 21 trisomy, 7 cases of D/G translocation and 2 cases of G/G translocation) and 170 Japanese controls. The weighting length and angle which effectively discriminate both groups were determined empirically from the results of these materials (Fig. 1, Table 8). As shown in Fig. 3, the areas proper to the Down's syndrome and the controls were sharply separated except for one point where one patient and one control individual were encountered. Therefore, the dis-

References

  1. Beckman, L., Gustavson, K. H. and Norring, A. 1965. Dermal configurations in the diagnosis of the Down syndrome: An attempt at a simplified scoring method.Acta Genet. (Basel)15: 3–12.

  2. Bolling, D. R., Borgaonkar, D. S., Herr, H. M. and Davis, M. 1971. Evaluation of dermal patterns in Down's syndrome by predictive discrimination. II. Composite score based on the combination of left and right pattern areas.Clin. Genet. 2: 163–169.

  3. Borgaonkar, D. S., Davis, M., Bolling, D. R. and Herr, H. M. 1967. Evaluation of dermal patterns in Down's syndrome by predictive discrimination. Amer. Soc. Hum. Gen., program and abstracts, December, 1967, Toronto, Canada, p. 19.

  4. Borgaonkar, D. S., Davis, M., Bolling, D. R. and Herr, H. M. 1971. Evaluation of dermal patterns in Down's syndrome by predictive discrimination. I. Preliminary analysis based on frequencies of patterns.Johns Hopk. Med. J. 128: 141–152.

  5. Cummins, H. 1936. Dermatoglyphic stigmata in mongolian idiocy.Anat. Rec. 64: 11.

  6. Cummins, H. 1939. Dermatoglyphic stigmata in mongoloid imbeciles.Anat. Rec. 73: 407–415.

  7. Deckers, J. F. M., Oorthuys, A. M. A. and Doesburg, W. H. 1973a. Dermatoglyphics in Down's syndrome. I. Evaluation of discriminating ability of pattern areas.Clin. Genet. 4: 311–317.

  8. Deckers, J. F. M., Oorthuys, A. M. A. and Doesburg, W. H. 1973b. Dermatoglyphics in Down's syndrome. II. Evaluation of scoring methods.Clin. Genet. 4: 318–327.

  9. Deckers, J. F. M., Oorthuys, A. M. A. and Doesburg, W. H. 1973c. Dermatoglyphics in Down's syndrome. III. Proposal of a simplified scoring method.Clin. Genet. 4: 381–387.

  10. Hsu, L. Y. F., Gertner, M., Leiter, E. and Hirschhorn, K. 1971. Paternal trisomy 21 mosaicism and Down's syndrome.Amer. J. Hum. Genet. 23: 592–601.

  11. Lejeune, J., Gautier, M. and Turpin, R. 1959. Études des chromosomes somatiques de neuf enfants mongoliens.C. R. Acad. Sci. (Paris) 248: 1721–1722.

  12. Loesch, D. 1974. Dermatoglyphic characteristics of 21-trisomy mosaicism in relation to the fully developed syndrome and normality.J. Ment. Defic. Res. 18: 209–269.

  13. Matsui, I., Nakagome, Y. and Higurashi, M. 1966. Dermatoglyphic study of Down's syndrome in Japan.Paediat. Univ. Tokyo 13: 43–48.

  14. Méhes, K. 1973. Paternal trisomy 21 mosaicism and Down's anomaly.Humangenetik 17: 297–300.

  15. Moorhead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M. and Hungerford, D. A. 1960. Chromosome preparations of leukocytes cultured from human peripheral blood.Exp. Cell Res. 20: 613–616.

  16. Mulvihill, J. J. and Smith, D. W. 1969. The genesis of dermatoglyphics.J. Pediat. 75: 579–589.

  17. Penrose, L. S. 1954. The distal triradiust on the hands of parents and sibs of mongol imbeciles.Ann. Hum. Genet. 19: 10–38.

  18. Penrose, L. S. 1965. Dermatoglyphics in mosaic mongolism and allied conditions.Genetics Today (Oxford: Pergamon Press)3: 973–980.

  19. Penrose, L. S. 1968. Memorandum on dermatoglyphic nomenclature. Birth Defects Original Article Series 4 (3), National Foundation-March of Dimes, New York.

  20. Penrose, L. S. and Loesch, D. 1971. Diagnosis with dermatoglyphic discriminants.J. Ment. Defic. Res. 15: 185–195.

  21. Preus, M. and Fraser, F. C. 1972. Dermatoglyphics and syndromes.Amer. J. Dis. Child. 124: 933–943.

  22. Priest, J. H. 1969. Parental dermatoglyphs in age-independent mongolism.J. Med. Genet. 6: 304–309.

  23. Priest, J. H., Verhulst, C. and Sirkin, S. 1973. Parental dermatoglyphics in Down's syndrome. A ten-year study.J. Med. Genet. 10: 328–332.

  24. Priest, J. H., Tishler, P. V. and Rosner, B. 1976. Dermatoglyphics in mosaic Down's syndrome.Clin. Genet. 9: 417–426.

  25. Purvis-Smith, S. G. and Menser, M. A. 1973. Genetic and environmental influences on digital dermatoglyphics in congenital rubella.Pediat. Res. 7: 215–219.

  26. Reed, T. E., Borgaonkar, D. S., Conneally, P. M., Yu, P., Nance, W. E. and Christian, J. C. 1970. Dermatoglyphic nomogram for the diagnosis of Down's syndrome.J. Pediat. 77: 1024–1032.

  27. Shiono, H., Kadowaki, J. and Kasahara, S. 1969. Dermatoglyphics of Down's syndrome in Japan.Tohoku J. Exp. Med. 99: 107–113.

  28. Smith, D. W., Therman, E. M., Patau, K. A. and Inhorn, S. L. 1962. Mosaicism in mother of two mongoloids.Amer. J. Dis. Child. 104: 534.

  29. Uchida, I. A. and Soltan, H. C. 1963. Evaluation of dermatoglyphics in medical genetics.Pediat. Clin. N. Amer. 10: 409–422.

  30. Uchida, I. A. and Soltan, H. C. 1969. Dermatoglyphics in medical genetics. Endocrine and Genetic Diseases of Childhood, ed. by Gardner, L. I., Saunders Publ., Philadelphia, pp. 583–592.

  31. Verresen, H., Van den Berghe, H. and Greemers, J. 1964. Mosaic trisomy in phenotypically normal mother of mongol.Lancet 1: 526–527.

  32. v. Greyerz-Gloor, R. D., Auf der Maur, P. und Riedwyl, H. 1969. Beurteilung des diagnostischen Wertes der Finger-und Handleistenmerkmale von Mongoloiden unter Anwendung einer Diskriminanzanalyse.Humangenetik 8: 195–207.

  33. Walker, N. F. 1957. The use of dermal configurations in the diagnosis of mongolism.J. Pediat. 50: 19–26.

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Kimura, S. Discrimination of Down's syndrome with dermatoglyphic examination: An application of two dimensional graphic representation. Jap J Human Genet 23, 39–58 (1978). https://doi.org/10.1007/BF01871381

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Keywords

  • Cancer Research
  • Graphic Representation
  • Index Finger
  • Control Individual
  • Pattern Type