Summary
The distribution of three common phenotypes of the human red cell soluble GPT has been determined in 145 inhabitants of an isolated community in western Japan. The frequency of two common alleles,Gpt 1=0.528 andGpt 2=0.472, revealed somewhat different values, as compared with those of neighbouring populations. In addition, quantitative differences between the three common phenotypes of the red cell GPT has been demonstrated.
Similar content being viewed by others
Article PDF
References
Blake, N. M. 1976. Glutamic pyruvic transaminase and esterase D types in the Asian-Pacific area.Human Genet. 35: 91–102.
Brinkmann, B., Krukenberg, P., Brinkmann, M. and Hoppe, H. H. 1972. Gene frequencies of soluble glutamic-pyruvic-transaminase in a Northern German population (Hamburg).Humangenetik 16:355–356.
Chen, S. H. and Giblett, E. R. 1971. Polymorphism of soluble glutamic-pyruvic transaminase: a new genetic marker in man.Science 173: 148–149.
Chen, S. H., Giblett, E. R., Anderson, J. E. and Fossum, B.L.G. 1972. Genetics of glutamicpyruvic transaminase: its inheritance, common and rare variants, population distribution, and differences in catalytic activity.Ann. Human Genet. 35: 401–409.
Ishimoto, G. and Kuwata, M. 1974. Red cell glutamic-pyruvic transaminase polymorphism in Japanese populations.Jap. J. Human Genet. 18: 373–377.
Ishimoto, G. 1975. Red cell enzyme.In Anthropological and Genetic Studies on the Japanese (S. Watanabe, S. Kondo and E. Matsunaga, eds.), Chap. 3, Tokyo Univ. Press, Tokyo, p. 109.
Kömpf, J. 1971. Population genetics of soluble glutamic-pyruvic transaminase [EC: 2.6.1.2]: gene frequencies in Southwestern Germany.Humangenetik 14: 76–77.
McAlpine, P. J., Chen, S. H., Cox, D. W., Dossetor, J. B., Giblett, E. R., Steinberg, A. G. and Simpson, N. E. 1974. Genetic markers in blood in a Canadian Eskimo population with a comparison of allele frequencies in Circumpolar populations.Human Hered. 24: 114–142.
Olaisen, B. and Teisberg, P. 1972. Erythrocyte alanine aminotransferase polymorphism in Norwegian Lapps.Human Hered. 22: 380–386.
Olaisen, B. 1973a. Two rare GPT phenotypes in a Norwegian family: evidence of seventh allele.Humangenetik 19: 289–291.
Olaisen, B. 1973b. Atypical segregation of erythrocyte glutamic-pyruvic transaminase in a Norwegian family.Human Hered. 23: 595–602.
Olaisen, B. 1975. Distribution of GPT types in Norway.Human Hered. 25: 20–29.
Santachiara Benerecetti, A. B., Beretta, M. and Pampiglione, S. 1975. Red cell glutamic-pyruvic transaminase polymorphism in a sample of the Italian population. A new variant allele:GPT8.Human Hered. 25: 276–278.
Seth, S. 1974. Population genetics of soluble glutamic-pyruvic-transaminase in North Germans (Lübeck).Humangenetik 23: 223–226.
Spielmann, W., Kühnl, P., Rexrodt, Ch. und Hänsel, G. 1973. Untersuchungen zum GPT-System unter besonderer Berücksichtigung des stummen Allels GPT0.Humangenetik 18: 341–348.
Welch, S. G. 1972. Quantitative differences between the human red cell glutamate-pyruvate transaminase phenotypes.Human Hered. 22: 190–197.
Welch, S. G., Mills, P. R. and Gaensslen, R. E. 1975. Phenotypic distributions of red cell glutamate-pyruvate transaminase [E.C. 2.6.1.2] isoenzymes in British and New York populations.Humangenetik 27: 59–62.
Welch, S. 1975. Comparative studies on the human glutamate-pyruvate transaminase phenotypes-GPT 1, GPT 2-1, GPT 2.Humangenetik 30: 237–249.
Yamamoto, M., Wada, T., Watanabe, T., Kanazawa, H., Saito, R., Kondo, M., Hosokawa, K., Masuda, M., Nakai, T. and Fujiki, N. 1972. Genetic polymorphisms in four isolated communities in Kinki district.Jap. J. Human Genet. 17: 273–285.
Author information
Authors and Affiliations
Additional information
Supported in part by a grant from the Ministry of Education, Science and Culture of Japan.
Rights and permissions
About this article
Cite this article
Nishigaki, I., Suzuki, H., Fujiki, N. et al. Genetic polymorphism of human red cell glutamic-pyruvic transaminase in an isolated community in western Japan. Jap J Human Genet 23, 9–15 (1978). https://doi.org/10.1007/BF01871377
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01871377
Keywords
This article is cited by
-
Expression profiles of the genes associated with metabolism and transport of amino acids and their derivatives in rat liver regeneration
Amino Acids (2008)
-
Human red cell GPT polymorphism: Comparison of the activities among different phenotypes using pyruvate andl-glutamate as substrates
Japanese journal of human genetics (1979)