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Uncertainty in the estimated risk of lung function decrements owing to ozone exposure

Abstract

In the most recent Health Risk and Exposure Assessment (HREA) for Ozone, the US Environmental Protection Agency (EPA) used an exposure–response function estimated on clinical data to calculate the risk of lung function decrements in a series of population-level simulations. These risk estimates are subject to both statistical uncertainty (which arises because the exposure–response function was estimated on a sample of clinical observations) and model uncertainty (which arises because there are different plausible ways to model the relationship between ozone exposure and lung function decrement). In this paper, we describe and apply an approach that allows us to estimate the statistical uncertainty present in these risk estimates. In the example we consider, statistical uncertainty produces 95% confidence intervals on the risk estimates that in some cases include zero, suggesting that in these cases we cannot exclude the possibility of no health risk to lung function owing to ozone exposure. Model uncertainty is also apparent, with a plausible alternative model specification leading to a substantially different distribution of risk.

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References

  1. US EPA. Health Risk and Exposure Assessment for Ozone (Final Report). EPA Office of Air Quality Planning and Standards: Research Triangle Park, NC, USA. 2014a, EPA-452/R-14-004a.

  2. US EPA. Total Risk Integrated Methodology (TRIM) - Air Pollutants Exposure Model Documentation (TRIM.Expo / APEX, Version 4.5) Volume I: User’s Guide. EPA Office of Air Quality Planning and Standards: Research Triangle Park, NC, USA. 2012a, EPA-452/B-12-001a.

  3. US EPA. Total Risk Integrated Methodology (TRIM) - Air Pollutants Exposure Model Documentation (TRIM.Expo / APEX, Version 4.5) Volume II: Technical Support Document. EPA Office of Air Quality Planning and Standards: Research Triangle Park, NC, USA. 2012b, EPA-452/B-12-001b.

  4. McDonnell WF, Stewart PW, Smith MV, Kim CS, Schelegle ES . Prediction of lung function response for populations exposed to a wide range of ozone conditions. Inhal Toxicol 2012; 24: 619–633.

    Article  CAS  Google Scholar 

  5. US EPA. Health Risk and Exposure Assessment for Ozone (Final Report), Chapter 6 Appendices. EPA Office of Air Quality Planning and Standards: Research Triangle Park, NC, USA. 2014b, EPA-452/R-14-004d.

  6. Smith AE, Gans W . Enhancing the characterization of epistemic uncertainties in PM2.5 risk analyses. Risk Anal 2015; 35: 361–378.

    Article  Google Scholar 

  7. Krinsky I, Robb AL . On approximating the statistical properties of elasticities. Rev Econ Stat 1986; 68: 715–719.

    Article  Google Scholar 

  8. Krinsky I, Robb AL . On approximating the statistical properties of elasticities: a correction. Rev Econ Stat 1990; 72: 189–190.

    Article  Google Scholar 

  9. Cameron AC, Trivedi PK . Microeconomics: Methods and Applications. Cambridge University Press: New York, USA. 2005, 1034 pp.

    Book  Google Scholar 

  10. McDonnell WF, Stewart PW, Smith MV . Ozone exposure-response model for lung function changes: an alternate variability structure. Inhal Toxicol 2013; 25: 348–353.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

An earlier version of this work was conducted with funding from the American Petroleum Institute. We thank Will Ollison for helpful comments on an earlier draft of this article.

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Correspondence to Garrett Glasgow.

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Glasgow, G., Smith, A. Uncertainty in the estimated risk of lung function decrements owing to ozone exposure. J Expo Sci Environ Epidemiol 27, 535–538 (2017). https://doi.org/10.1038/jes.2016.39

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