Abstract
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is highly prevalent in pigs and veal calves. The environment and air in pig and veal calf barns is often contaminated with LA-MRSA, and can act as a transmission source for humans. This study explores exposure–response relationships between sequence type 398 (ST398) MRSA air exposure level and nasal ST398 MRSA carriage in people working and/or living on farms. Samples and data were used from three longitudinal field studies in pig and veal calf farm populations. Samples consisted of nasal swabs from the human participants and electrostatic dust fall collectors capturing airborne settled dust in barns. In both multivariate and mutually adjusted analyses, a strong association was found between nasal ST398 MRSA carriage in people working in the barns for >20 h per week and MRSA air levels. In people working in the barns < 20 h per week there was a strong association between nasal carriage and number of working hours. Exposure to ST398 MRSA in barn air seems to be an important determinant for nasal carriage, especially in the highly exposed group of farmers, next to duration of contact with animals. Intervention measures should therefore probably also target reduction of ST398 MRSA air levels.
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Acknowledgements
We would like to acknowledge all field workers and laboratory assistants, especially Isabella Oosting-van Schothorst, Arjen Timmerman and Marian Broekhuizen-Stins. The research included in this paper was funded by Senter Novem, The Netherlands Organization for Health Research and Development (ZonMw) (grant numbers 125020009 and 505170098053), the Product Boards for Livestock Meat and Eggs, and the Dutch Ministry of Agriculture Nature and Food Quality (POM and BACTOPATH projects).
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Bos, M., Verstappen, K., van Cleef, B. et al. Transmission through air as a possible route of exposure for MRSA. J Expo Sci Environ Epidemiol 26, 263–269 (2016). https://doi.org/10.1038/jes.2014.85
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DOI: https://doi.org/10.1038/jes.2014.85
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