Personal care product use and urinary phthalate metabolite and paraben concentrations during pregnancy among women from a fertility clinic


Parabens and phthalates are potential endocrine disruptors frequently used in personal care/beauty products, and the developing fetus may be sensitive to these chemicals. We measured urinary butyl-paraben (BP), methyl-paraben, propyl-paraben, mono-n-butyl phthalate (MBP), and monoethyl phthalate (MEP) concentrations up to three times in 177 pregnant women from a fertility clinic in Boston, MA. Using linear mixed models, we examined the relationship between self-reported personal care product use in the previous 24 h and urinary paraben and phthalate metabolite concentrations. Lotion, cosmetic, and cologne/perfume use were associated with the greatest increases in the molar sum of phthalate metabolite and paraben concentrations, although the magnitude of individual biomarker increases varied by product used. For example, women who used lotion had BP concentrations 111% higher (95% confidence interval (CI): 41%, 216%) than non-users, whereas their MBP concentrations were only 28% higher (CI: 2%, 62%). Women using cologne/perfume had MEP concentrations 167% (CI: 98%, 261%) higher than non-users, but BP concentrations were similar. We observed a monotonic dose–response relationship between the total number of products used and urinary paraben and phthalate metabolite concentrations. These results suggest that questionnaire data may be useful for assessing exposure to a mixture of chemicals from personal care products during pregnancy.


Personal care products often contain both parabens and phthalates, which are suspected endocrine-disrupting compounds (EDCs).1, 2 Individuals may be simultaneously exposed to both chemical classes as they use multiple products that contain these chemicals (e.g., lotion and cosmetics) and/or both classes of chemicals may be found in a single product. Women of reproductive age have higher urinary concentrations of phthalate metabolites and parabens than men, suggesting that personal care product use may be an important source of exposure among women.3, 4, 5 This may be of particular concern to the developing fetus, which is often more sensitive to the effects of EDCs than adults.6

Derivatives of para-hydroxybenzoic acid, including butyl-paraben (BP), ethyl-paraben (EP), methyl-paraben (MP), and propyl-paraben (PP), are commonly used as antimicrobial agents to increase personal care and beauty product shelf life.7 Parabens are suspected of having weak estrogenic and anti-androgenic activity that may increase the risk of adverse health outcomes in experimental animals, including altered gonadal hormone signaling or metabolism and spermatogenesis.8, 9, 10, 11, 12 The relative biological activity of the different parabens increases with the alkyl side chain length, but is several orders of magnitude lower than that of estradiol.11

Phthalic acid esters like dibutyl phthalate (DBP) and diethyl phthalate (DEP) are used to retain scents in cologne/perfumes and deliver agents in aerosols.13 DBP has well-documented anti-androgenic effects in rats, whereas DEP does not.14 Some phthalates may have very weak estrogenic activity.15 Human studies suggest that fetal DBP and DEP exposure may increase the risk of adverse health outcomes during early childhood.16, 17, 18, 19

Prior studies have confirmed that some personal care products may be modifiable sources of phthalate or paraben exposures; however, few studies have considered exposure to mixtures of both parabens and phthalates.20, 21, 22, 23, 24 As mixtures, some EDCs may act additively or multiplicatively to increase the risk of adverse health effects.14, 25

Using repeated urinary biomarker concentrations and questionnaires, we characterized the relationship between DBP, DEP, BP, MP, and PP exposure and personal care product use in pregnant women. We focused on these phthalates and parabens because of their known or suspected presence in personal care products.7, 13 Because exposure may occur as a mixture, we used self-reported personal care product use as a surrogate of exposure to both classes of chemicals to determine whether the total personal care product use was associated with higher paraben and phthalate exposure.



The Environment and Reproductive Health (EARTH) Study recruited women 18–45 years old and male partners seeking evaluation and treatment for infertility at the Massachusetts General Hospital Fertility Center in Boston between March 2005 and March 2011. The present analysis is from a larger prospective pre-conception open-cohort study designed to examine the relationship between environmental chemical exposures and fertility/pregnancy outcomes. Details of the methods and participants have been previously described.26, 27 Women were eligible for the present analysis if they had a live birth, provided at least one urine sample during pregnancy, completed a questionnaire at the time of urine collection about their personal care product use in the past 24 h, and had complete covariate data.

The Human Studies Institutional Review Boards of the Massachusetts General Hospital, Harvard School of Public Health, and the Centers for Disease Control and Prevention (CDC) approved this study. Study protocols were explained and all questions were answered by a trained research nurse before participants provided informed consent.

Urine Sample Collection and Analytic Measurements

Women provided up to three spot urine samples during pregnancy at routine clinic visits. The time of sample collection was recorded on a standardized form. Before aliquoting and storing samples at −80 °C, urine specific gravity (SG) was measured using a handheld refractometer (National Instrument Company, Baltimore, MD, USA) that was calibrated with deionized water before each use. Samples were shipped overnight on dry ice to the CDC for analysis.

We measured the total concentration of two phthalate metabolites and three parabens: mono-n-butyl phthalate (MBP), monoethyl phthalate (MEP), BP, MP, and PP, using previously described solid phase extraction-high-performance liquid chromatography-isotope dilution tandem mass spectrometry methods and quality control procedures.3, 28, 29, 30 We did not measure ethyl paraben concentrations in this study because of its relatively low frequency of detection in the US population.4 The limits of detection (LOD) for MBP, MEP, BP, MP, and PP were in the low μg/l range (0.1 to 1 μg/l). All paraben and phthalate metabolite concentrations were SG standardized (median SG: 1.015) using a modification of a previously described formula.21 Concentrations below the LOD were given a value of the LOD/√2.31 Because the analytic standard for MEP was of inadequate purity, we applied a correction factor of 0.66 to MEP concentrations.32

We characterized biomarker concentrations in three different ways. First, we examined each individual paraben or phthalate metabolite. Second, we calculated the sum of the molar concentrations of urinary phthalate metabolites and parabens. Finally, we created a relative estrogenicity equivalency factor (EEF) summary measure using an approach outlined by Safe and Shirai and results from in vitro yeast reporter assay data from Harris and Routledge.11, 12, 15, 33 We assumed that MBP, MEP, BP, MP, and PP were 10,000,000; 2,000,000; 10,000; 2,500,000; and 30,000 times less potent than 17β-estradiol, respectively. We calculated the EEF (μmol/l) as follows:

where [MBP], [MEP], [BP], [MP], and [PP] are the micromolar concentrations (μmol/l) of the chemicals. The final EEF is expressed in units of estrogenic activity relative to estradiol. We did not create a similar summary measure for the anti-androgenic activity of MEP and MBP, because MEP does not possess anti-androgenic activity in rodent models and comparable data for parabens and phthalates do not exist.14 All of these measures were log10-transformed to satisfy regression model assumptions.

Personal Care Product Use

Women completed a questionnaire at the time of urine collection that asked if and when they used 13 personal care products that are applied to the skin or scalp in the past 24 h. These included deodorant, shampoo, conditioner/crème rinse, hairspray/hair gel, other hair care products (e.g., mousse, hair bleach, relaxer, perm), shaving cream, cologne/perfume, bar soap, liquid soap/body wash, hand/body lotion, colored cosmetics (hair dye, foundation, blush, eye shadow, eye liner, or mascara), suntan/sunblock lotion, and nail polish.

We used two approaches to characterize women’s personal care product use. First, we examined the use of each product separately (yes vs no). Second, we summed the total number of products used in the last 24 h and categorized women into three product user groups corresponding to the bottom 30% (low users, 0–5 products), middle 41% (medium users, 6–7 products), and top 29% (high users, 8–11 products) of product users. We calculated the number and proportion of women using individual products within these three categories to better understand the patterns of product use among low, medium, and high product users.


We obtained women’s age at baseline, race, and education using a standardized questionnaire. A trained research nurse recorded women’s weight and height at each study visit, which was used to compute body mass index (BMI). The estimated date of conception was calculated using one of three dating methods: oocyte retrieval date, which was abstracted from medical records; crown rump length, which was measured during a fetal ultrasound between 6 and 8 weeks gestation; or woman’s report of last menstrual period. When more than one dating method was available, priority was given to retrieval date>ultrasound>last menstrual period. The date of conception was used to compute the week of pregnancy each urine sample was collected.

Statistical Analysis

We calculated univariate characteristics (counts, proportions, means, and standard deviations (SD)) of demographic factors and examined the distribution of urinary phthalate and paraben concentrations using box and whisker plots. We examined the correlation between pairs of log10-transformed urinary biomarker concentrations using Pearson correlation coefficients.

We began our statistical analyses by examining personal care product use in relation to each phthalate metabolite and paraben concentration using linear mixed models with an unstructured covariance matrix and random intercept for each woman to account for repeated measurements. Urinary phthalate metabolite or paraben concentrations were the outcome in these models and we calculated the percent change in biomarker or summary measure concentration with the various characterizations of personal care product use by exponentiating the beta coefficients from these models. We also computed the covariate-adjusted least squares geometric mean (GM) biomarker concentrations among women with and without personal care product use.

All models were adjusted for weeks of gestation (time varying), maternal age at enrollment, education, race, and BMI (time varying). Models examining individual personal care products were also adjusted for the total number of other personal care products used, not counting the one being examined.

As a sensitivity analysis, we examined whether urinary phthalate metabolite and paraben concentrations varied according to the time since the product was last used by calculating GM concentrations according to categories of no product use, product use >6–24 h ago, and product use in the last 6 h. We also adjusted our primary analyses for the time of day of personal care product use and season of sample collection to determine if adjustment for other activities that co-vary with personal care product use or calendar time biased our results.


A total of 266 women had a live birth and 205 of these women (77%) provided at least one urine sample and completed a product use questionnaire during pregnancy. One-hundred and seventy-seven women (67%) who had complete covariate, personal care product questionnaire, and urinary phthalate metabolite data together provided 391 urine samples. Most women provided two (41%) or three (40%) urine samples. Complete data and urinary paraben concentrations were available for 170 (64%) women.

Women included in the primary analyses were on average 35.7 years old (SD: 4.0) and predominately non-Hispanic (97%), Caucasian (91%), college educated (95%), and had normal BMI (67%). Most women conceived with in vitro fertilization methods (63%), whereas the rest conceived naturally (18%) or with intrauterine insemination (19%). On average, within each trimester, urine samples and questionnaires were collected at 5.6 (SD: 1.6; range: 1.4–12.3), 20.0 (SD: 3.5; range 12.1–29.3), and 33.5 (SD: 2.5, range: 25.6, 38.4) weeks since conception.

The range of urinary phthalate metabolite and paraben concentrations spanned approximately 3–4 orders of magnitude with median molar biomarker concentrations decreasing in order of MP>MEP>PP>MBP>BP (Figure 1, Supplementary Table 1, and Supplementary Figure 1). Detection frequencies ranged from 72% for BP to 100% for MEP. Urinary MP and PP concentrations were strongly correlated (Pearson R=0.87), whereas BP was weakly correlated with MP and PP (Pearson R=0.29–0.31). MEP and MBP concentrations were also weakly correlated (Pearson R=0.26). The other correlations between urinary phthalate metabolite and paraben concentrations were generally weak (Pearson R=0.05–0.38).

Figure 1

Box and whisker plots of specific gravity-adjusted urinary phthalate metabolite and paraben concentrations (μg/l) during pregnancy among women with a live birth from the EARTH Study. BP, butyl paraben; MBP, monobutyl phthalate; MEP, monoethyl phthalate; MP, methyl paraben; PP, propyl paraben.

Among the 13 personal care products queried for in our survey, women reported using liquid soap (85%) and deodorant (84%) most frequently in the last 24 h (Table 1 and Figure 2). Sun lotion (14%) and nail polish (4%) were the least frequently used personal care products. The proportion of women using specific products changed across product use categories (0–5, 6-7, and 8–11 products) (Figure 2). The majority of women used deodorant, bar soap, liquid soap, or lotion in all three categories, but the proportion of women using these products increased across the three categories of use. The use of products like shampoo, conditioner, hair gel, other hair products, cologne/perfume, cosmetics, or sun lotion increased considerably from the lowest to highest categories.

Table 1 Adjusted change in specific gravity standardized urinary phthalate metabolite and paraben concentrations according to personal care product use in the previous 24 h among 177 pregnant women with a live birth from the EARTH Study.a,b
Figure 2

Proportion of visits women reported using specific personal products in the last 24-hours according to categorical personal care product use among pregnant women with a live birth from the EARTH study. Categories are defined as 0–5 (low), 6–7 (medium), and 8–11 (high) products used in the last 24 h. Numbers are based on the 391 visits completed by 177 women (n=128, 146, and 117 for low, medium, and high use, respectively).

On average, women who used lotion, cosmetics, cologne/perfume, nail polish, sun lotion, or hair gel had total molar urinary phthalate metabolite and paraben concentrations 28–80% higher than non-users of these products (Table 1). The pattern of metabolite increases varied according to the product used. Lotion users had urinary BP and PP concentrations two to three times higher compared with non-users, but their urinary MBP concentrations were only 28% higher (95% confidence interval (CI): 2, 62; Figure 3 and Table 1). Cologne users had MEP and MP concentrations 167% (CI:98, 261%) and 45% (CI: 4, 102%) higher than non-users. The small number (n=7) of women reporting nail polish use in the last 24 h had higher urinary concentrations of MBP (88; CI: 14, 211) and MEP (152; CI: 30, 388), but not of parabens, compared with non-users.

Figure 3

Adjusted percent change in specific gravity standardized urinary phthalate metabolite and paraben concentrations with personal care product use in the last 24 h among pregnant women with a live birth from the EARTH study. Separate models for each predictor and outcome. Models adjusted for maternal race (white vs non-white), education (graduate school vs no graduate school), age (years), body mass index (continuous, time varying), weeks gestation (time varying), and number of other personal care products used (continuous, time varying). Products are sorted in order of the largest (top) to smallest (bottom) change in the phthalate and paraben molar sum concentrations. BP, butyl paraben; MBP, monobutyl phthalate; MEP, monoethyl phthalate; MP, methyl paraben; PP, propyl paraben.

Women who reported using shampoo, conditioner, other hair products, and liquid soap had slightly lower total molar phthalate metabolite and paraben concentrations compared with non-users, although the CI of these estimates included the null value. Adjusted GM urinary phthalate metabolite and paraben concentrations according to product use are shown in Supplementary Table 3.

After weighting the parabens and phthalate metabolites concentrations by their relative estrogenicity, the rank order of the paraben and phthalate metabolites changed (Supplementary Figures 1 and 2). Urinary PP concentrations were now the highest, followed by BP, MBP, MEP, and MBP concentrations (Supplementary Figure 2). Log10-transformed EEF and total molar sum concentrations were highly correlated (Pearson R=0.90). When we examined the relationship between personal care product use and the EEF, the results were relatively similar to those we observed when we used molar sum of phthalate metabolites and parabens (Table 2). However, deodorant and sun lotion use were now associated with the 3rd and 4th largest change in the EEF, respectively, although the CI of the sun lotion estimate included the null value.

Table 2 Adjusted change in specific gravity standardized Estrogenicity Equivalence Factor according to personal care product use in the last 24 h among pregnant women with a live birth from the EARTH study.a,b

Women who reported using more personal care products had higher urinary concentrations of all the phthalate metabolites and parabens (Figure 4 and Supplementary Table 4). The largest relative increases were observed for PP followed by MP>MEP>BP>MBP. Compared with low product users, PP concentrations were 219% higher (CI: 94, 423) in high users, whereas MBP concentrations were 61% (CI: 22, 111) higher. Urinary MBP concentrations among low and medium product users were relatively similar.

Figure 4

Adjusted geometric mean specific gravity-standardized urinary phthalate metabolite and paraben concentrations according to the number of personal care product use in the last 24 h among pregnant women with a live birth from the EARTH study. Separate models for each predictor and outcome. Models adjusted for maternal race (white vs non-white), education (graduate school vs no graduate school), age (years), body mass index (continuous, time-varying), and weeks gestation (time varying). Grey line represents the overall geometric mean. Error bars are the 95% CI of the geometric mean. BP, butyl paraben; MBP, monobutyl phthalate; MEP, monoethyl phthalate; MP, methyl paraben; PP, propyl paraben.

The time between product use and urine sample collection influenced urinary phthalate metabolite and paraben concentrations (Supplementary Figure 3). For almost all of the products, biomarker concentrations were highest among women who used the product in the last 6 h, lower for those using in the last 6–24 h, and lowest among non-users. Of note were the higher urinary MEP (GM: 183 μg/l; CI: 96, 348) and BP (GM: 4.2 μg/l; CI: 1.8, 9.7) concentrations among women who used shave cream in the last 6 h compared with women who did not use shave cream (MEP GM: 55 μg/l; CI: 46, 66 and BP GM: 1.5 μg/l; CI: 1.1, 1.9) or used it >6 h before the urine sample collection (MEP GM: 48 μg/l; CI: 30, 76; and BP GM: 1.7 μg/l; CI: 0.9, 3.1).

Adjusting for the time of day the product was used or the season of the year the sample was collected did not substantively change most of our results (results not shown). Adjusting for time of day attenuated the relationship between sun lotion use and urinary MP concentrations, whereas strengthening the relationship with urinary PP concentrations.


There is a growing interest in determining the health effects associated with the wide range of environmental exposures experienced across the life course that make up the ‘exposome’ and we attempted to characterize a component of exposures related to personal care product use.34 In this cohort, individual and summary measures of urinary phthalate metabolite and paraben concentrations were higher in pregnant women who reported using lotion, cosmetics, cologne/perfume, hair gel, and nail polish in the last 24 h compared with women not using these products. Among lotion users these increases were due to higher concentrations of multiple chemicals (i.e., all three parabens). In contrast, the increases among cosmetic users were due to higher concentrations of both phthalate metabolites and parabens.

The concentrations of and correlations between urinary phthalate metabolites and parabens observed in this study were similar to other studies conducted in Japan, the Netherlands, France, Spain, and the United States.4, 5, 12, 23, 35, 36, 37, 38, 39 The high correlation between MP and PP is likely due to their joint use as antimicrobials in foods and personal care products.

Parabens are used in thousands of personal care products, typically at levels less than 1% (w/w).7 Despite their relatively low concentrations and the wide degree of variability in paraben levels by brand and product formulation, we observed higher paraben and phthalate metabolite concentrations in the urine of users of lotion, cosmetics, and hair gel, compared with non-users. Some phthalates are used at relatively high concentrations in some products like cologne/perfume.1, 13, 38, 40 Consistent with our findings, two surveys have detected DEP and parabens in some of the same products.1, 38 Despite previous studies detecting at least one paraben and phthalate in all 13 products examined in this study,1 we observed null or modestly negative associations between some products and urinary paraben or phthalate concentrations. We speculate that this may be due to the relatively short dermal contact time of certain products (e.g., liquid soap, shampoo, and conditioner), reduced statistical precision due to few individuals with or without product use (e.g., liquid soap and sun lotion), or low paraben/phthalate concentrations in the specific products used by our participants.

Several epidemiological studies have examined the relationships between self-reported product use and urinary paraben and/or phthalate metabolite concentrations. Three epidemiological studies of men and women have reported higher urinary MEP concentrations among cologne/cologne/perfume users compared with non-users.21, 23, 41 The 167% increase observed in this study is similar to the results of Parlett et al. and Just et al. reporting MEP concentrations 129% and 192% higher among cologne/perfume users compared with non-users, respectively. Consistent with our findings related to lotion, two studies of non-pregnant Mexican women and pregnant Puerto Ricans observed increased urinary MEP and paraben concentrations among lotion users, respectively.24, 42 The study of Puerto Rican women also reported higher urinary paraben concentration among women using cosmetics. A prior study of pregnant women in New York City did not report higher MBP concentrations among women who used nail polish or polish remover; however, they asked about use in the last 48 h, whereas we asked about use in the last 24 h.23 Another study of pregnant women observed higher urinary MBP concentrations among lotion and nail polish users compared with non-users.20 However, they did not observe higher MEP concentrations among cologne/perfume users. Janjua et al. in Denmark applied body lotion containing DBP (2%), DEP (2%), and BP (2%) every day to 26 male volunteers for a week.22 Metabolites of all three chemicals rose dramatically in 24-h urine samples collected after lotion application. Discrepancies in the findings across these studies could be due to differences in questionnaire design, timing of urine sample collection in relation to product use, product reformulation over time, and the types or brands of products used by the study participants in their respective source populations.

The higher concentrations of urinary phthalate metabolites and parabens among women using more personal care products suggests that the number of personal care products used may be a sensitive, but non-specific indicator of exposure to these phthalate diesters and parabens. Although the use of questionnaire data is appealing for epidemiological studies, many personal care products contain other chemicals that may have endocrine disrupting properties, thus, reducing the specificity of a questionnaire.1 However, questionnaires are simple to administer and inexpensive compared with biological monitoring. Therefore, in studies with very large sample sizes (e.g., n>1000) or limited budgets, questionnaires may be useful surrogates for ranking exposure to multiple EDCs found in personal care products. Future studies using questionnaires could reduce exposure misclassification by obtaining information about the time since a product was last used as we observed higher urinary biomarker concentrations among women who used certain personal care products in the last 6 h compared with women who used them >6 h ago. Questionnaires should be designed to take into account the biological half-life of the compounds of interest, as well as the variability in exposure patterns.

Our results were similar when we used either the total molar sum or the biologically weighted EEF. Compared with the total molar sum, which assumes that different chemicals have equivalent toxicity, the EEF for these five chemicals is a biologically based estimate of the relative total estrogenic potential and may provide a more relevant estimate of exposure than a molar sum. However, the absolute EEF among lotion users was still orders of magnitude below that of estradiol. Although the anti-androgenic activity of DBP has been described in relation to other phthalates, animal data do not suggest that DEP is anti-androgenic and there are not comparable data for parabens, thus limiting our ability to create a biologically weighted anti-androgenic sum for these phthalates and parabens.43

The toxic equivalency approach we employed for summarizing parabens and phthalates has been used for dioxin-like compounds, where toxicity data from animal studies has been applied to human studies.33, 44 One limitation of this approach in epidemiological studies is the assumption that all the chemicals within a class act via a single mechanism that is equivalent in both humans and the experimental system used to estimate relative toxicity. Chemicals can have multiple mechanisms of toxicity and the assumption of a single mechanism is questionable when different chemical classes are being examined, especially when extrapolating from in vitro to in vivo models. For the present study, it may not be appropriate to sum urinary phthalate metabolite and paraben concentrations if they act through multiple or different biological pathways. Statistically, these summary measures may not provide additional information beyond a simple sum if the individual chemicals are highly correlated, the relative potencies of the chemicals are similar, or one chemical’s concentration is orders of magnitude higher than the others. Additional multidisciplinary research is needed to determine if and how different chemical exposures can be summarized to better characterize the potential human health hazard related to mixtures.

Our study is limited by sources of variability in the measurement of personal care product use and urinary biomarker concentrations. We did not collect information about the amount or brand of products used. Prior studies have reported relatively high variability in the amount of personal care product applied by individuals and this may be one factor that contributes to the within-person variability of urinary biomarker concentrations.26, 27, 45, 46 Differences in product formulations might result in even higher or lower exposures for users of specific brands.7 These products may also contain other endocrine-disrupting chemicals like triclosan or benzophenone.1 Future studies could use new strategies to estimate the chemical content from product labels and combine this with the amount and frequency of product use.47

Our previous work in this cohort did not suggest that pregnancy-induced changes in metabolism or excretion were responsible for systematic changes in these paraben or phthalate metabolite concentrations before or during pregnancy.26, 27 However, urinary phthalate metabolite and paraben concentrations have moderate within-person variability during pregnancy due in part to the short biological half-life of these compounds (<24 h).26, 27 This may necessitate multiple spot urine samples to classify gestational exposure. Indeed, a strength of the current study was the repeated urine measurements, allowing us to incorporate this variability into our estimates.


Pregnant women in this cohort who reported using lotion, cosmetics, hair gel, and cologne/perfume had higher concentrations of a mixture of phthalate metabolites and parabens in their urine compared with non-users of these products. These findings are consistent with prior studies documenting the presence of phthalates and parabens in personal care products and epidemiological studies observing higher biomarkers of exposure among users of personal care products. Self-reported product use questionnaires may be a sensitive, but non-specific technique to quantify exposure to a mixture of EDCs in epidemiological studies. Future studies should continue to explore human exposure to chemical mixtures and the relevance of these mixtures to human health.



body mass index




Centers for Disease Control and Prevention


confidence interval


dibutyl phthalate


diethyl phthalate


endocrine-disrupting compound


mono-n-butyl phthalate


monoethyl phthalate






specific gravity


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We acknowledge the technical assistance of M. Silva, E. Samandar, J. Preau, X. Ye, X. Zhou, R. Hennings, and J. Tao (Centers for Disease Control and Prevention (CDC)) in measuring the urinary concentrations of phthalate metabolites and parabens. This work was funded by NIEHS grants T32 ES007069, R01 ES009718, P30 ES000002, and R00 ES020346.

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Correspondence to Joe M Braun.

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The authors declare no conflict of interest.

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The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the CDC.

Supplementary Information accompanies the paper on the Journal of Exposure Science and Environmental Epidemiology website

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Braun, J., Just, A., Williams, P. et al. Personal care product use and urinary phthalate metabolite and paraben concentrations during pregnancy among women from a fertility clinic. J Expo Sci Environ Epidemiol 24, 459–466 (2014).

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  • endocrine disruptors
  • epidemiology
  • mixtures
  • parabens
  • phthalates

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