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The evolution of EPA's Exposure Factors Handbook and its future as an exposure assessment resource

Abstract

The need to compile and summarize exposure factors data into a resource document was first established in 1983 after the publication of the National Academy of Sciences (NAS) report on Risk Assessment in the Federal Government: Managing the Process and subsequent publication of the Environmental Protection Agency's (EPA's) exposure guidelines in 1986 (NAS, 1983; US EPA, 1986). During the same time frame, the EPA published a report entitled Development of Statistical Distributions or Ranges of Standard Factors Used in Exposure Assessment to promote consistency among various exposure assessment activities in which EPA was involved and to serve as a support document to the 1986 exposure guidelines (US EPA, 1985). As the exposure assessment field continued to advance during the 1980s and 1990s, so did the need for more comprehensive data on exposure factors. The Exposure Factors Handbook was first published in 1989 in response to this need (US EPA, 1989). It became an important reference document and has been revised and updated since its original publication (US EPA, 1989; US EPA, 1997a; US EPA, 2011a). This paper reviews the evolution of the Exposure Factors Handbook, and explores anticipated needs and some of the potential options for future updates of the handbook.

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References

  1. NAS (National Academy of Science). Risk Assessment in the Federal Government: Managing the Process. National Academy Press, Washington DC, 1983.

  2. US EPA (United States Environmental Protection Agency). Guidelines for estimating exposures. Federal Register 1986: 51: 34042–34054.

    Google Scholar 

  3. US EPA (United States Environmental Protection Agency). Development of Statistical Distributions or Ranges of Standard Factors Used in Exposure Assessment. US Environmental Protection Agency, Washington, DC, EPA/600/8-85/010, 1985. Available from the National Technical Information Service (5285 Port Royal Road, Springfield, VA 22161.

  4. US EPA (United States Environmental Protection Agency). Exposure Factors Handbook. Office of Research and Development, United States Environmental Protection Agency, Washington, DC, EPA 600/8-89/043, 1989.

  5. US EPA (United States Environmental Protection Agency). Exposure Factors Handbook. Office of Research and Development, United States Environmental Protection Agency, Washington, DC, EPA-600-P95-F, 1997a. Available at http://www.epa.gov/ncea/efh/.

  6. US EPA (United States Environmental Protection Agency). Exposure Factors Handbook: 2011 Edition. Office of Research and Development, United States Environmental Protection Agency, Washington, DC, EPA/600/R-09/052F, 2011a. Available at http://www.epa.gov/ncea/efh/report.html.

  7. EC (European Commission). Joint Research Centre. ExpoFacts Project Information. Available at http://expofacts.jrc.ec.europa.eu/index.php?category=proj_info&source=proj_info&PHPSESSID=jupj66b39c8em4bp8p529o6fu0 (accessed 15 June 2011).

  8. Kim S., Cheong H.K., Choi K., Yang J.Y., Kim S.J., Jo S.N., et al. Development of Korean Exposure Factors Handbook for exposure assessment. Epidemiology 2006: 17 (6): S460.

    Article  Google Scholar 

  9. Jang J.Y., Jo S.N., Kim S.J., Kim S., and Cheong H.K. Development of Korean Exposure Factors Handbook. Epidemiology 2008: 19 (6): S214.

    Google Scholar 

  10. Gamo M., and Futatsumata M. Development of Japanese Exposure Factors Handbook. Epidemiology 2006: 17 (6): S528–S529.

    Article  Google Scholar 

  11. Aldridge J.E., Gibbons J.A., Flaherty M.M., Kreider M.L., Romano J.A., and Levin E.D. Heterogeneity of toxicant response: sources of human variability. Toxicol Sci 2003: 76: 3–20.

    Article  CAS  PubMed  Google Scholar 

  12. US EPA (United States Environmental Protection Agency). Human Health Research Strategy. Office of Research and Development, United States Environmental Protection Agency, Washington, DC, EPA-600-R-02-050, 2003. Available at http://www.epa.gov/nheerl/humanhealth/HHRS_final_web.pdf.

  13. US EPA (United States Environmental Protection Agency). Aging and Toxic Response: Issues Relevant to Risk Assessment (Final). Office of Research and Development, U.S. Environmental Protection Agency, Washington, D.C. EPA/600/P-03/004A, 2005a. Available at http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=156648.

  14. US EPA (United States Environmental Protection Agency). A Framework for Assessing Health Risk of Environmental Exposures to Children (Final). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-05/093F, 2006a. Available at http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=158363.

  15. US EPA (United States Environmental Protection Agency). Physiological Parameters Database for Older Adults (Beta 1.1). Office of Research and Development, Washington, DC, 2008a. Available at http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=201924.

  16. Geller A.M., and Zenick H. Aging and the environment: a research framework. Environ Health Pers 2005: 113 (9): 1257–1262. Available at http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.7569.

    Article  Google Scholar 

  17. Pellizzarri E. Farewell note. J Expo Sci Environ Epid 2006: 16 (1): 1–2.

    Article  Google Scholar 

  18. Firestone M. Protecting children from environemtnal risks throughout each stage of their childhood. J Expo Sci Environ Epidemiol 2010: 20 (3): 227.

    Article  PubMed  Google Scholar 

  19. US EPA (United States Environmental Protection Agency). Guidance on Selecting Age Groups for Monitoring and Assessing Childhood Exposures to Environmental Contaminants. Risk Assessment Forum, United States Environmental Protection Agency, Washington, DC, EPA/630/P-03/003F, 2005b. Available at http://www.epa.gov/raf/publications/guidance-on-selecting-age-groups.htm.

  20. US EPA (United States Environmental Protection Agency). Child-Specific Exposure Factors Handbook. Office of Research and Development, Washington, DC. EPA/600/R-06/096F, 2008b. Available at http://cfpub.epa.gov/ncea/CFM/recordisplay.cfm?deid=199243.

  21. US EPA (United States Environmental Protection Agency). SHEDS-Multimedia. Details of SHEDS-Multimedia version 3: ORD/NERL's model to estimate aggregate and cumulative exposures to chemicals, 2009a. Available at http://www.epa.gov/heasd/products/sheds_multimedia/sheds_mm.html.

  22. US EPA (United States Environmental Protection Agency). Exploration of Aging and the Toxic Response. Risk Assessment Forum, United States Environmental Protection Agency, Washington, DC, 2001a. Available at http://www.epa.gov/osainter/raf/publications/aging-toxic-response.htm.

  23. US EPA (United States Environmental Protection Agency). Exploration of Perinatal Pharmacokinetic Issues. Risk Assessment Forum, United States Environmental Protection Agency, Washington, DC, EPA/630/R-01/004, 2001b. Available at http://www.epa.gov/raf/publications/pdfs/PPKFINAL.PDF.

  24. US Department of Labor (U.S. DL), Bureau of Labor Statistics. American Time Use Survey – 2006 Results 2007. News release issued at http://www.bls.gov/tus (accessed 28 June 2007).

  25. US Bureau of the Census. American Housing Survey for the United States in 2007. U.S. Government Printing Office, Washington, DC, 2008.

  26. US EPA (United States Environmental Protection Agency). Dermal Exposure Assessment: A Summary of EPA Approaches. United States Environmental Protection Agency, Office of Research and Development, Washington, DC EPA600/R-07/040F, 2007a.

  27. Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Data files, Hyattsville, MD, 2011. Available at http://www.cdc.gov/nchs/nhanes.htm.

  28. Xue J., Zartarian V., Moya J., Freeman N., Beamer P., Black K., et al A meta-analysis of children's hand-to-mouth frequency data for estimating nondietary ingestion exposure. Risk Anal 2007: 27 (2): 411–420.

    Article  PubMed  Google Scholar 

  29. Xue J., Zartarian V., Tulve N., Moya J., Freeman N., AuYeung W., et al A meta-analysis of children's object-to-mouth frequency data for estimating nondietary ingestion exposure. J Expo Sci Environ Epidemiol 2009; e-pub ahead of print 23 September 2009. Available at http://www.nature.com/jes/journal/vaop/ncurrent/pdf/jes200942a.pdf.

  30. US EPA (United States Environmental Protection Agency). Guidelines for Exposure Assessment. Office of Research and Development, United States Environmental Protection Agency, Washington DC, EPA/600/Z-92/001, 1992. Available at http://www.epa.gov/NCEA/raf/pdfs/exposure.pdf.

  31. US EPA (United States Environmental Protection Agency). Guidance for Risk Characterization. Science Policy Council, United States Environmental Protection Agency, Washington, DC, 1995. Available at http://www.epa.gov/spc/pdfs/rcguide.pdf.

  32. US EPA (United States Environmental Protection Agency). Policy for Use of Probabilistic Analysis in Risk Assessment. Risk Assessment Forum, United States Environmental Protection Agency, Washington DC, 1997b. Available at http://www.epa.gov/spc/pdfs/probpol.pdf.

  33. US EPA (United States Environmental Protection Agency). Guiding Principles for Monte Carlo Analysis. Risk Assessment Forum, United States Environmental Protection Agency, Washington DC EPA/630/R-97/001, 1997c. Available at http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=29596.

  34. NAS (National Academy of Science). Pesticides in the Diets of Infants and Children. National Academy of Press, Washington DC, 1993.

  35. FQPA (Food Quality Protection Act of 1996). Public Law 104-170, 1996. Available at http://www.epa.gov/pesticides/regulating/laws/fqpa/gpogate.pdf.

  36. EO (Executive Order). 13045, Protection of children from environmental health risks and safety risks. Federal Register 1997: 62: 19883–19888.

    Google Scholar 

  37. Moya J., Bearer C.F., and Etzel R.A. Children's behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics 2004: 13 (4): 996–1006.

    Google Scholar 

  38. US EPA (United States Environmental Protection Agency). Child-Specific Exposure Factors Handbook, Interim Report. Office of Research and Development, United States Environmental Protection Agency, Washington, DC, EPA-600-P-00-002B, 2002. Available at http://cfpub.epa.gov/ncea/CFM/recordisplay.cfm?deid=199243.

  39. US EPA (United States Environmental Protection Agency). Child-Specific Exposure Factors Handbook, External Review Draft. Office of Research and Development, United States Environmental Protection Agency, Washington, DC, EPA-600-R-06-096A, 2006b. Available at http://cfpub.epa.gov/ncea/CFM/recordisplay.cfm?deid=199243.

  40. US EPA (United States Environmental Protection Agency). Highlights of the Child-specific Exposure Factors Handbook. Office of Research and Development, United States Environmental Protection Agency, Washington, DC, EPA/600/R-08/135, 2009b. Available at http://cfpub.epa.gov/ncea/CFM/recordisplay.cfm?deid=199243.

  41. US EPA (United States Environmental Protection Agency). Example Exposure Scenarios. Office of Research and Development, United States Environmental Protection Agency, Washington, DC, EPA-600-R-03-036, 2004. Available at http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=85843.

  42. NCHS (National Center for Health Statistics). Joint policy on variance estimation and statistical reporting standards on NHANES III and CSFII reports: HNIS/NCHS analytic working group recommendations. Human Nutrition Information Service (HNIS)/Analytic Working Group, 1993. Available from: Agricultural Research Service, Survey Systems/Food Consumption Laboratory, 4700 River Road, Unit 83, Riverdale, MD.

  43. US EPA (United States Environmental Protection Agency). Food Commodity Intake Database [FCID Raw Data File]. Office of Pesticide Programs, United States Environmental Protection Agency, Washington, DC, 2000a. Available from the National Technical Information Service, (5285 Port Royal Road, Springfield, VA 22161.

  44. Popkin B.M. Patterns of beverage use across the lifecycle. Physiol Behav 2010: 100 (1): 4–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Portier K., Tolson J., and Roberts S. Body weight distributions for risk assessment. Risk Anal 2007: 27 (1): 11–26.

    Article  PubMed  Google Scholar 

  46. Freedman D., Kettel K., Serdula M., Ogden C., and Dietz W. Racial and ethnic differences in secular trends for childhood BMI, weight, and height. Obesity 2006: 14 (2): 301: 307.

    Article  PubMed  Google Scholar 

  47. Lioy P.J. Exposure science: a view of the past and milestones for the future. Environ Health Pers 2010: 118 (8): 1081–1090.

    Article  Google Scholar 

  48. US EPA (United States Environmental Protection Agency). Exposure Factors Handbook, External Review Draft. Office of Research and Development, United States Environmental Protection Agency, Washington, DC, 2009c. Available at http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=209866.

  49. US EPA (United States Environmental Protection Agency). Descriptive Statistics Tables from a Detailed Analysis of the National Human Activity Pattern Survey (NHAPS) Data. Office of Research and Development, Washington, DC. EPA/600/R-96/148 1996.

  50. US EPA (United States Environmental Protection Agency). Consolidated Human Activity Database (CHAD). United States Environmental Protection, Office of Research and Development, National Exposure Research Laboratory, 2000b. Available online at http://www.epa.gov/chadnet1/.

  51. Zartarian V.G., Ferguson A.C., Ong C.G., and Leckie J. Quantifying videotaped activity patterns: video translation software and training methodologies. J Expo Anal Environ Epidemiol 1997: 7 (4): 535–542.

    CAS  PubMed  Google Scholar 

  52. Özkaynak H., Xue J., Zartarian V.G., Glen G., and Smith L. Modeled estimates of soil and dust ingestion rates for children. Risk Anal 2010: 31 (4): 592–608.

    Article  PubMed  Google Scholar 

  53. Landrigan P.J., Sonawane B., Mattison D., McCally M., and Garg A. Chemical contaminants in breast milk and their impacts on children's health: an overview. Environ Health Pers 2002: 110 (6): 313–315.

    Article  Google Scholar 

  54. US EPA (United States Environmental Protection Agency). Important Exposure Factors for Children An Analysis of Laboratory and Observational Field Data Characterizing Cumulative Exposure to Pesticides. United States Environmental Protection Agency, Office of Research and Development, Washington, DC EPA 600/R-07/013, 2007b. Available at http://www.epa.gov/nerl/research/data/exposure-factors.pdf.

  55. US EPA (United States Environmental Protection Agency). Standard Operating Procedures (SOPs) for Residential Exposure Assessment. Residential Exposure Assessment Workgroup, United States Environmental Protection Agency, Washington, DC, 1997d. Available at http://www.epa.gov/oppfead1/trac/science/trac6a05.pdf.

  56. US Department of Energy (US DOE). Commercial Buildings Energy Consumption Survey (CBECS). Form EIA-871A 2008. Available online at eia.doe.gov/emeu/cbecs, U.S. Department of Energy, Energy Information Administration, Washington, DC.

  57. US EPA (United States Environmental Protection Agency). Highlights of the Exposure Factors Handbook. United States Environmental Protection Agency, Office of Research and Development, Washington, DC, EPA-600-R-10/030, 2011b. Available at http://cfpub.epa.gov/ncea/risk/recorddisplay.cfm?deid=221023.

  58. ERG (Eastern Research Group). Report on the Peer Review of the Child-specific Exposure Factors Handbook, 2006 External Review Draft, 2007.

  59. Contaminants of Potential Concern (COPC) Committee. World Trade Center Indoor Environment Assessment: Selecting Contaminants of Potential Concern and Setting Health-Based Benchmarks 2003: http://www.epa.gov/WTC/.

  60. Battelle Summary report of the U.S. EPA colloquium on soil/dust ingestion rates and mouthing behavior for children and adults. Prepared by Battelle under EPA contract EP-C-04-027. 2005. Available at http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=146585.

  61. NAS (National Academy of Science). Science and Decisions: Advancing Risk Assessment. National Academy of Press, Washington DC, 2009.

  62. NAS (National Academy of Science). Toxicity Testing in the 21st Century: A Vision and a Strategy. National Academy of Press, Washington DC, 2007.

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Acknowledgements

We thank Dr. Jeffrey Frithsen, US EPA for his suggestions and comments.

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The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the US Environmental Protection Agency.

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Correspondence to Linda Phillips.

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Phillips, L., Moya, J. The evolution of EPA's Exposure Factors Handbook and its future as an exposure assessment resource. J Expo Sci Environ Epidemiol 23, 13–21 (2013). https://doi.org/10.1038/jes.2012.77

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