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Exposures of preschool children to chlorpyrifos, diazinon, pentachlorophenol, and 2,4-dichlorophenoxyacetic acid over 3 years from 2003 to 2005: A longitudinal model

Journal of Exposure Science & Environmental Epidemiology volume 20, pages 546–558 (2010)Cite this article

Abstract

The impact of the US EPA-required phase-outs starting in 2000–2001 of residential uses of the organophosphate (OP) pesticides chlorpyrifos (CPF) and diazinon (DZN) on preschool children's pesticide exposures was investigated over 2003–2005, in the Raleigh-Durham-Chapel Hill area of North Carolina. Data were collected from 50 homes, each with a child initially of age 3 years (OCh) and a younger child (YCh). Environmental samples (indoor and outdoor air, dust, soil) and child-specific samples (hand surface residue, urine, diet) were collected annually over 24-h periods at each home. Child time-activity diaries and household pesticide use information were also collected. Analytes included CPF and DZN; pentachlorophenol (PCP); 2,4-dichlorophenoxyacetic acid (2,4-D); the CPF metabolite 3,5,6-trichloro-2-pyridinol (TCP); and the DZN metabolite 2-isopropyl-6-methyl-4-pyrimidinol (IMP). Exposures (ng/day) through the inhalation, dietary ingestion, and indirect ingestion were calculated. Aggregate potential doses in ng/kg body weight per day (ng/kg/day) were obtained by summing the potential doses through the three routes of exposure. Geometric mean aggregate potential doses decreased from 2003 to 2005 for both OCh and YCh, with the exception of 2,4-D. Child-specific longitudinal modeling indicated significant declines across time of the potential doses of CPF, DZN, and PCP for both children; declines of IMP for both children, significant only for OCh; a decline of TCP for OCh but an increase of TCP for YCh; and no significant change of 2,4-D for either child. Age-adjusted modeling indicated significant effects of the child's age for all except CPF, and of time for all except PCP and 2,4-D. Within-home variability was small compared with that between homes; variability was smallest for 2,4-D, both within and between homes. The aggregate potential doses of CPF and DZN were well below published reference dose values. These findings show the success of the US EPA restrictions in reducing young children's pesticide exposures.

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Acknowledgements

This research was funded in part by the USEPA National Center for Environmental Research (NCER) through STAR Grant R829363 to Battelle Memorial Institute. We also thank Dr. Chris Saint, the Project Officer at NCER; Christopher Lyu and the field staff at Battelle's Center for Public Health Research in Durham, NC; and Marielle C. Brinkman, the database staff, Kelley M Hand and the laboratory staff at Battelle's Columbus, OH laboratories.

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  1. Battelle Centers for Public Health Research and Evaluation, Durham, North Carolina, USA

    Nancy K Wilson

  2. Battelle, Columbus, Ohio, USA

    Warren J Strauss, Nicole Iroz-Elardo & Jane C Chuang

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  1. Nancy K Wilson
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Correspondence to Nancy K Wilson.

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Wilson, N., Strauss, W., Iroz-Elardo, N. et al. Exposures of preschool children to chlorpyrifos, diazinon, pentachlorophenol, and 2,4-dichlorophenoxyacetic acid over 3 years from 2003 to 2005: A longitudinal model. J Expo Sci Environ Epidemiol 20, 546–558 (2010). https://doi.org/10.1038/jes.2009.45

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