Morimoto, S., Takahashi, Y., Watanabe, Y. & Ōmura, S. Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-O-methylerythromycins A. J. Antibiot. 37, 187–189 (1984).
Slobodan, D. et al. Erythromycin series. Part 13. Synthesis and structure elucidation of 10-dihydro-10-deoxo-11-methyl-11-azaerythromycin A. J. Chem. Res. Synop. 1988, 152–153 (1988).
Ajito, K., Miura, T., Furuuchi, T. & Tamura, A. Sixteen-membered macrolides: chemical modifications and future applications. Heterocycles 89, 281–352 (2014).
Sato, T. et al. In vitro antibacterial activity of modithromycin, a novel 6,11-bridged bicyclolide, against respiratory pathogens, including macrolide-resistant Gram-positive cocci. Antimicrob. Agents Chemother. 55, 1588–1593 (2011).
Denis, A. et al. Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens. Bioorg. Med. Chem. Lett. 9, 3075–3080 (1999).
Clay, K. D. et al. Severe hepatotoxicity of telithromycin: three case reports and literature review. Ann. Intern. Med. 144, 415–420 (2006).
Miura, T. et al. Novel azalides derived from sixteen-membered macrolides. I. Isolation of the mobile dialdehyde and its one-pot macrocyclization with an amine. J. Antibiot. 60, 407–435 (2007).
Miura, T. et al. Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4” positions: improved antibacterial activities. Bioorg. Med. Chem. 18, 2735–2747 (2010).
Mason, D. J., Dietz, A. & Deboer, C. Lincomycin, a new antibiotic I. Discovery and biological properties. Antimicrob. Agents Chemother. 1962, 554–559 (1962).
Birkenmeyer, R. D. & Kagan, F. Lincomycin. XI. Synthesis and structure of clindamycin. A potent antibacterial agent. J. Med. Chem. 13, 616–619 (1970).
Weisblum, B. Erythromycin resistance by ribosome modification. Antimicrob. Agents Chemother. 39, 577–585 (1995).
Tsuzuki, K. et al. Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal. Chem. Pharm. Bull. 37, 2687–2700 (1989).
Shah, P. J., Vakil, N. & Kabakov, A. Role of intravenous immune globulin in streptococcal toxic shock syndrome and Clostridium difficile infection. Am. J. Health Syst. Pharm. 72, 1013–1019 (2015).
Sztaricskai, F. et al. Semisynthetic modification of antibiotic lincomycin. J. Antibiot. 49, 941–943 (1996).
Goffic, L. F. Structure activity relationships in lincosamide and streptogramin antibiotics. J. Antimicrob. Chemother. 16(Suppl A), 13–21 (1985).
Umemura, E. et al. Synthesis of novel lincomycin derivatives and their in vitro antibacterial activities. J. Antibiot. 66, 195–198 (2013).
Wakiyama, Y. et al. Synthesis and structure–activity relationships of novel lincomycin derivatives. Part 1. Newly generated antibacterial activities against Gram-positive bacteria with erm gene by C-7 modification. J. Antibiot. 69, 368–380 (2016).
Wakiyama, Y. et al. Synthesis and structure-activity relationships of novel lincomycin derivatives. Part 2. Synthesis of 7(S)-7-deoxy-7-(4-morpholinocarbonylphenylthio)lincomycin and its 3-dimensional analysis with rRNA. J. Antibiot. 69, 428–439 (2016).
Wakiyama, Y. et al. Synthesis and structure-activity relationships of novel lincomycin derivatives part 3: discovery of the 4-(pyrimidin-5-yl)phenyl group in synthesis of 7(S)-thiolincomycin analogs. J. Antibiot. 70, 52–64 (2017).
Kumura, K. et al. Synthesis and antibacterial activity of novel lincomycin derivatives. I. Enhancement of antibacterial activities by introduction of substituted azetidines. J. Antibiot. 69, 440–445 (2016).
Kumura, K. et al. Synthesis and antibacterial activity of novel lincomycin derivatives. II. Synthesis and antibacterial activity of novel lincomycin derivatives. II. Exploring (7S -7-(5-aryl-1,3,4-thiadiazol-2-yl-thio)-7-deoxylincomycin derivatives. J. Antibiot. 70, 655–663 (2017).
Kumura, K. et al. Synthesis and antibacterial activity of novel lincomycin derivatives. III. Optimization of a phenyl thiadiazole moiety. J. Antibiot. doi:10.1038/ja.2017.59 (2017).
Birkenmeyer, R. D., Kroll, S. J., Lewis, C., Stern, K. F. & Zurenko, G. E. Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, a potent antibacterial agent. J. Med. Chem. 27, 216–223 (1984).
Lewis, J. G. et al The lincomycin derivatives possessing antibacterial activity. WO/2004/016632 A2, 26 February (2004).
Lewis, J. G. et al Novel Antimicrobial 7-Methyl Lincosamides: Pipecolamide Analogs. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. Poster F-1389 (2004).
Lopez, S. L. et al Characterization of the Spectrum of In Vitro Activity of VIC-105555, a New Lincosamide. 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. Poster F-2038 (2004).
O’Dowd, H. et al. Novel antibacterial azetidine lincosamides. Bioorg. Med. Chem. Lett 18, 2645–2648 (2008).
Shuman, R. T., Ornstein, P. L., Paschal, J. W. & Gesellchen, P. D. An improved synthesis of homoproline and derivatives. J. Org. Chem. 55, 738–741 (1990).
Schroeder, W., Bannister, B. & Hoeksema, H. Lincomycin. III. The structure and stereochemistry of the carbohydrate moiety. J. Am. Chem. Soc. 89, 2448–2453 (1967).
Eldere, J. V. et al. Overview of antimicrobial options for Mycoplasma pneumoniae pneumonia: focus on macrolide resistance. Clin. Respir. J. 11, 419–429 (2017).