Bisoxazolomycin A: a new natural product from ‘Streptomyces subflavus subsp. irumaensis’ AM-3603

  • The Journal of Antibiotics volume 70, pages 11421145 (2017)
  • doi:10.1038/ja.2017.113
  • Download Citation
Published online:


Bisoxazolomycin (1), oxazolomycin A2 (2) and oxazolomycin A (3) were identified by physicochemical screening approach from a culture broth of ‘Streptomyces subflavus subsp. irumaensis’ AM-3603. Compound 2 is a hydrolyzed analog of 3 at the β-lactone ring, and 1 is a new dimeric analog of 2. Compounds 1 and 2 exhibited less potent antibacterial activity and cytotoxicity than 3, which might be due to lack of the β-lactone ring.

  • Subscribe to The Journal of Antibiotics for full access:



Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.


  1. 1.

    , & Search for new compounds from Kitasato microbial library by physicochemical screening. Biochem. Pharmacol. 15, 42–55 (2017).

  2. 2.

    et al. Irumamycin, an antifungal 20-membered macrolide produced by a Streptomyces: Taxonomy, fermentation and biological properties. J. Antibiot. 37, 1572–1578 (1984).

  3. 3.

    et al. Structure of oxazolomycin, a novel β-lactone antibiotic. Tetrahedron Lett. 26, 1073–1076 (1985).

  4. 4.

    , , & Inhibitory effect of oxazolomycin on Crown Gall formation. Agric. Biol. Chem. 53, 1127–1133 (1989).

  5. 5.

    , , , & Total synthesis of Oxazolomycin A. Org. Lett. 13, 5398–5401 (2011).

Download references


We are grateful to Dr Masato Iwatsuki for helpful advice. This project was supported by JSPS and NRCT under the Japan - Thailand Research Cooperative Program, the Thailand Research Fund under Royal Golden Jubilee Ph.D. Program (Grant No. PHD/0205/2553) and the Institute for Fermentation, Osaka (IFO), Japan.

Author information

Author notes

    • Wilaiwan Koomsiri
    •  & Yuki Inahashi

    These authors contributed equally to this work.


  1. Department of Genetics, Faculty of Science, Kasetsart University, Bangkok, Thailand

    • Wilaiwan Koomsiri
    •  & Arinthip Thamchaipenet
  2. Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan

    • Yuki Inahashi
    • , Kazuro Shiomi
    • , Yōko Takahashi
    • , Satoshi Ōmura
    •  & Takuji Nakashima
  3. Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan

    • Yuki Inahashi
    • , Tōru Kimura
    • , Kazuro Shiomi
    •  & Takuji Nakashima
  4. Center for Advanced Studies in Tropical Natural Resources, National Research-University-Kasetsart University (CASTNAR, NRU-KU), Kasetsart University, Bangkok, Thailand

    • Arinthip Thamchaipenet


  1. Search for Wilaiwan Koomsiri in:

  2. Search for Yuki Inahashi in:

  3. Search for Tōru Kimura in:

  4. Search for Kazuro Shiomi in:

  5. Search for Yōko Takahashi in:

  6. Search for Satoshi Ōmura in:

  7. Search for Arinthip Thamchaipenet in:

  8. Search for Takuji Nakashima in:

Competing interests

The authors declare no conflict of interest.

Corresponding authors

Correspondence to Arinthip Thamchaipenet or Takuji Nakashima.

Supplementary information

Supplementary Information accompanies the paper on The Journal of Antibiotics website (