Note

Bisoxazolomycin A: a new natural product from ‘Streptomyces subflavus subsp. irumaensis’ AM-3603

  • The Journal of Antibiotics volume 70, pages 11421145 (2017)
  • doi:10.1038/ja.2017.113
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Abstract

Bisoxazolomycin (1), oxazolomycin A2 (2) and oxazolomycin A (3) were identified by physicochemical screening approach from a culture broth of ‘Streptomyces subflavus subsp. irumaensis’ AM-3603. Compound 2 is a hydrolyzed analog of 3 at the β-lactone ring, and 1 is a new dimeric analog of 2. Compounds 1 and 2 exhibited less potent antibacterial activity and cytotoxicity than 3, which might be due to lack of the β-lactone ring.

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Acknowledgements

We are grateful to Dr Masato Iwatsuki for helpful advice. This project was supported by JSPS and NRCT under the Japan - Thailand Research Cooperative Program, the Thailand Research Fund under Royal Golden Jubilee Ph.D. Program (Grant No. PHD/0205/2553) and the Institute for Fermentation, Osaka (IFO), Japan.

Author information

Author notes

    • Wilaiwan Koomsiri
    •  & Yuki Inahashi

    These authors contributed equally to this work.

Affiliations

  1. Department of Genetics, Faculty of Science, Kasetsart University, Bangkok, Thailand

    • Wilaiwan Koomsiri
    •  & Arinthip Thamchaipenet
  2. Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan

    • Yuki Inahashi
    • , Kazuro Shiomi
    • , Yōko Takahashi
    • , Satoshi Ōmura
    •  & Takuji Nakashima
  3. Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan

    • Yuki Inahashi
    • , Tōru Kimura
    • , Kazuro Shiomi
    •  & Takuji Nakashima
  4. Center for Advanced Studies in Tropical Natural Resources, National Research-University-Kasetsart University (CASTNAR, NRU-KU), Kasetsart University, Bangkok, Thailand

    • Arinthip Thamchaipenet

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Competing interests

The authors declare no conflict of interest.

Corresponding authors

Correspondence to Arinthip Thamchaipenet or Takuji Nakashima.

Supplementary information

Supplementary Information accompanies the paper on The Journal of Antibiotics website (http://www.nature.com/ja)