Original Article

Pteridic acids C–G spirocyclic polyketides from the marine-derived Streptomyces sp. SCSGAA 0027

  • The Journal of Antibiotics volume 70, pages 10471052 (2017)
  • doi:10.1038/ja.2017.105
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Abstract

Five new pteridic acids C–G (15) were isolated from a culture broth of the marine-derived actinomycete Streptomyces sp. SCSGAA 0027. Their complete structures were elucidated on the basis of NMR data, modified Mosher’s method and quantum chemical calculations. Furthermore, their cytotoxicity, antiviral and antimicrobial activities were also evaluated.

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Acknowledgements

We are grateful for the financial support provided by the National Natural Science Foundation of China (41376160 and 81673326), National Natural Science Foundation of China (41606100), Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences (XDA100304002), Natural Science Foundation of Guangdong Province, China (2015A030310349) and Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development (GD2012-D01-002). We appreciate the contribution of the analytical facility center (Xiao Zhihui, Li Chuanrong, Sun Aijun and Zhang Yun) of South China Sea Institute of Oceanology, Chinese Academy of Sciences for acquiring NMR, HRESIMS and experimental CD data. We are also grateful for the support given by the Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences.

Author information

Affiliations

  1. Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China

    • Xu-Hua Nong
    •  & Shu-Hua Qi
  2. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, and Guangdong Provincial Key Laboratory of Digital Botanical Garden, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China

    • Xiao-Yi Wei

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Competing interests

The authors declare no conflict of interest.

Corresponding author

Correspondence to Shu-Hua Qi.

Supplementary information

Supplementary Information accompanies the paper on The Journal of Antibiotics website (http://www.nature.com/ja)